Abstract
Purpose
To evaluate the safety and efficacy of cryoablation for renal cell carcinoma (RCC) in patients with stage 4 or 5 non-dialysis chronic kidney disease (CKD).
Materials and methods
This retrospective multicenter study included patients with maximum tumor diameter ≤ 4 cm, estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73 m2, in whom cryoablation was performed percutaneously with curative intent between July 2011 and May 2016.
Results
Of 541 patients who underwent renal tumor cryoablation, 17 (3.1%; 4 women, 13 men; mean age 70.1 ± 10.6 years) with stage 4 or 5 non-dialysis CKD were included in this study. The pre-cryoablation eGFR was 22.5 ± 6.3 ml/min/1.73 m2. The mean tumor diameter was 2.8 ± 0.7 cm. No Grade 3 or higher adverse events occurred post-cryoablation. The eGFR at each time point was significantly lower than that before treatment. One patient required hemodialysis initiation at 21 months post-procedure. None of the patients showed residual RCC at their last follow-up.
Conclusion
Cryoablation of RCC is safe in patients with stage 4 or 5 non-dialysis CKD and yields treatment results comparable to those in patients without CKD. This treatment could be completed without the early initiation of hemodialysis after the procedure.
Similar content being viewed by others
References
Znaor A, Lortet-Tieulent J, Laversanne M, Jemal A, Bray F. International variations and trends in renal cell carcinoma incidence and mortality. Eur Urol. 2015;67:519–30.
Patard JJ. Incidental renal tumours. Curr Opin Urol. 2009;19:454–8.
Rabjerg M, Mikkelsen MN, Walter S, Marcussen N. Incidental renal neoplasms: is there a need for routine screening? A Danish single-center epidemiological study. APMIS. 2014;122:708–14.
Schmit GD, Thompson RH, Kurup AN, Weisbrod AJ, Carter RE, Callstrom MR, et al. Percutaneous cryoablation of solitary sporadic renal cell carcinomas. BJU Int. 2012;110(11 Pt B):E526–31.
Georgiades CS, Rodriguez R. Efficacy and safety of percutaneous cryoablation for stage 1A/B renal cell carcinoma: results of a prospective, single-arm, 5-year study. Cardiovasc Interv Radiol. 2014;37:1494–9.
Aoun HD, Littrup PJ, Jaber M, Memon F, Adam B, Krycia M, et al. Percutaneous cryoablation of renal tumors: is it time for a new paradigm shift? J Vasc Interv Radiol. 2017;28:1363–70.
Patel HD, Pierorazio PM, Johnson MH, Sharma R, Iyoha E, Allaf ME, et al. Renal functional outcomes after surgery, ablation, and active surveillance of localized renal tumors: a systematic review and meta-analysis. Clin J Am Soc Nephrol. 2017;12:1057–69.
Wehrenberg-Klee E, Clark TW, Malkowicz SB, Soulen MC, Wein AJ, Mondschein JI, et al. Impact on renal function of percutaneous thermal ablation of renal masses in patients with preexisting chronic kidney disease. J Vasc Interv Radiol. 2012;23:41–5.
Miyazaki M, Iguchi T, Takaki H, Yamanaka T, Tamura Y, Tokue H, et al. Ablation protocols and ancillary procedures in tumor ablation therapy: consensus from Japanese experts. Jpn J Radiol. 2016;34:647–56.
Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53:982–92.
Kutikov A, Uzzo RG. The R.E.N.A.L. nephrometry score: a comprehensive standardized system for quantitating renal tumor size, location and depth. J Urol. 2009;182:844–53.
Tonelli M, Wiebe N, Culleton B, House A, Rabbat C, Fok M, et al. Chronic kidney disease and mortality risk: a systematic review. J Am Soc Nephrol. 2006;17:2034–47.
Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296–305. (Erratum in: N Engl J Med 2008;18:4).
Levin A, Djurdjev O, Beaulieu M, Er L. Variability and risk factors for kidney disease progression and death following attainment of stage 4 CKD in a referred cohort. Am J Kidney Dis. 2008;52:661–71.
O'Hare AM, Bertenthal D, Walter LC, Garg AX, Covinsky K, Kaufman JS, et al. When to refer patients with chronic kidney disease for vascular access surgery: should age be a consideration? Kidney Int. 2007;71:555–61.
Ljungberg B, Bensalah K, Canfield S, Dabestani S, Hofmann F, Hora M, et al. EAU guidelines on renal cell carcinoma: 2014 update. Eur Urol. 2015;67:913–24.
Motzer RJ, Jonasch E, Agarwal N, Bhayani S, Bro WP, Chang SS, et al. Kidney cancer, version 2.2017, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Cancer Netw. 2017;15:804–34.
Mason RJ, Atwell TD, Lohse C, Bhindi B, Weisbrod A, Boorjian SA, et al. Renal functional outcomes in patients undergoing percutaneous cryoablation or partial nephrectomy for a solitary renal mass. BJU Int. 2017;120:544–9.
Maurice MJ, Ramirez D, Kara Ö, Malkoç E, Nelson RJ, Fareed K, et al. Optimum outcome achievement in partial nephrectomy for T1 renal masses: a contemporary analysis of open and robot-assisted cases. BJU Int. 2017;120:537–43.
Long JA, Bernhard JC, Bigot P, Lanchon C, Paparel P, Rioux-Leclercq N, et al. Partial nephrectomy versus ablative therapy for the treatment of renal tumors in an imperative setting. World J Urol. 2017;35:649–56.
Georgiades C, Rodriguez R, Azene E, Weiss C, Chaux A, Gonzalez-Roibon N, et al. Determination of the nonlethal margin inside the visible "ice-ball" during percutaneous cryoablation of renal tissue. Cardiovasc Interv Radiol. 2013;36:783–90.
Marenzi G, Marana I, Lauri G, Assanelli E, Grazi M, Campodonico J, et al. The prevention of radiocontrast-agent-induced nephropathy by hemofiltration. N Engl J Med. 2003;349:1333–400.
Thomsen HS. Nephrogenic systemic fibrosis: history and epidemiology. Radiol Clin N Am. 2009;47:827–81.
Ellison JS, Montgomery JS, Hafez KS, Miller DC, He C, Wolf JS Jr, et al. Association of RENAL nephrometry score with outcomes of minimally invasive partial nephrectomy. Int J Urol. 2013;20:564–70.
Roushias S, Vasdev N, Ganai B, Mafeld S, Rix D, Thomas D, et al. Can the R.e.N.a.L nephrometry score preoperatively predict postoperative clinical outcomes in patients undergoing open and laparoscopic partial nephrectomy? Curr Urol. 2013;7:90–7.
Sisul DM, Liss MA, Palazzi KL, Briles K, Mehrazin R, Gold RE, et al. RENAL nephrometry score is associated with complications after renal cryoablation: a multicenter analysis. Urology. 2013;81:775–80.
Blute Jr ML, Okhunov Z, Moreira DM, George AK, Sunday S, Lobko II K, et al. Image-guided percutaneous renal cryoablation: preoperative risk factors for recurrence and complications. BJU Int. 2013;111(4 Pt B):E181–85.
Funding
Nothing to disclose.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
Hideo Gobara and Takao Hiraki received funding from Okayama Prefecture, JPSS and AMED. Other authors have no conflict of interest to declare.
Ethical statement
Each institutional review board approved this retrospective multicenter study and waived the requirement for obtaining informed consent to use the patients’ medical data. All procedures performed were in accordance with the ethical standards of the institutional research committees and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
About this article
Cite this article
Gobara, H., Nakatsuka, A., Shimizu, K. et al. Cryoablation of renal cell carcinoma for patients with stage 4 or 5 non-dialysis chronic kidney disease. Jpn J Radiol 37, 481–486 (2019). https://doi.org/10.1007/s11604-019-00821-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11604-019-00821-7