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Comparison between solid component size on thin-section CT and pathologic lymph node metastasis and local invasion in T1 lung adenocarcinoma

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Objectives

To correlate the tumor size and solid component size on thin-section CT (TS-CT) with pathological findings including lymph node (LN) metastasis and local invasion in T1 lung adenocarcinoma.

Methods

188 patients with surgically resected T1 lung adenocarcinoma were retrospectively analyzed. Two chest radiologists measured the long-axis and short-axis dimensions of nodules and solid components with a lung and/or a mediastinal window setting (WS) on TS-CT. After analyzing interobserver agreement, average long-axis dimensions of the measured tumors and solid components were correlated with pathological findings.

Results

Seven of 188 patients (3.7%) had pathologic LN-positive metastasis. In patients in whom the long axis of the solid component was <5 mm with a mediastinal WS or <8 mm with a lung WS on TS-CT, no LN metastases were observed, resulting in a positive predictive value (PPV) for predicting a pathologic LN-negative status of 100% with each WS. Based on the same diagnostic criteria, the PPVs for a pathological local invasion (LI)-negative status were 91 (40/44) and 90% (55/61), respectively.

Conclusion

Solid component size on TS-CT may have the potential to predict LN-negative or LI-negative status.

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Authors and Affiliations

  1. Unit of Translational Medicine, Department of Clinical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Hideyuki Hayashi, Kazuto Ashizawa & Minoru Fukuda

  2. Department of Radiological Science, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Akifumi Nishida & Masataka Uetani

  3. Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Keitaro Matsumoto, Naoya Yamasaki & Takeshi Nagayasu

  4. Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan

    Sumihisa Honda

  5. Department of Radiology, Nagasaki Prefectural Shimabara Hospital, Nagasaki, Japan

    Yukihiro Ogihara

Authors
  1. Hideyuki Hayashi
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  2. Kazuto Ashizawa
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  3. Yukihiro Ogihara
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  4. Akifumi Nishida
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  5. Keitaro Matsumoto
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  6. Naoya Yamasaki
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  7. Takeshi Nagayasu
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  8. Minoru Fukuda
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  9. Sumihisa Honda
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  10. Masataka Uetani
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Corresponding author

Correspondence to Kazuto Ashizawa.

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Conflict of interest

The requirement for informed consent was waived by the institutional review board for this retrospective study. The authors declare that they have no conflict of interest.

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Hayashi, H., Ashizawa, K., Ogihara, Y. et al. Comparison between solid component size on thin-section CT and pathologic lymph node metastasis and local invasion in T1 lung adenocarcinoma. Jpn J Radiol 35, 109–115 (2017). https://doi.org/10.1007/s11604-017-0610-6

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  • DOI: https://doi.org/10.1007/s11604-017-0610-6

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