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SUVmax on FDG-PET is a predictor of prognosis in patients with maxillary sinus cancer

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Abstract

Purpose

Our aim was to determine whether the maximum standardized uptake value (SUVmax) of the primary lesion demonstrated by [18F]-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is associated with the prognosis of maxillary sinus cancer.

Materials and methods

The relationships of clinicopathological factors including age, T stage, N stage, histologic type, treatment strategy, and primary tumor SUVmax with progression-free (PFS) and overall (OS) survival were evaluated using the log-rank test and Cox method in 31 patients with maxillary sinus cancer before combined superselective intra-arterial chemotherapy using high-dose cisplatin with concurrent radiotherapy, or radiotherapy alone.

Results

The median duration of follow-up was 55.4 (range 9.7–72.6) months. PFS and OS of patients exhibiting a high SUVmax (≥16 and ≥17, respectively) for the primary tumor were significantly lower than those of patients for whom the primary tumor SUVmax was low (p = 0.0010 and p = 0.033, respectively). Multivariate analyses showed that T stage (p = 0.0049) and primary tumor SUVmax (p = 0.026) were independently prognostic of poorer PFS and that only primary tumor SUVmax (p = 0.049) was independently prognostic of poorer OS.

Conclusion

SUVmax of the primary tumor determined by FDG-PET/CT before treatment could be a good surrogate marker for prognostication of maxillary sinus cancer.

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References

  1. Myers LL, Nussenbaum B, Bradford CR, Teknos TN, Esclamado RM, Wolf GT. Paranasal sinus malignancies: an 18-year single institution experience. Laryngoscope. 2002;112:1964–9.

    Article  PubMed  Google Scholar 

  2. Davies A, Tan C, Paschalides C, Barrington SF, O’Doherty M, Utley M, et al. FDG-PET maximum standardised uptake value is associated with variation in survival: analysis of 498 lung cancer patients. Lung Cancer. 2007;55:75–8.

    Article  PubMed  Google Scholar 

  3. Kato H, Nakajima M, Sohda M, Tanaka N, Inose T, Miyazaki T, et al. The clinical application of 18F-fluorodeoxyglucose positron emission tomography to predict survival in patients with operable esophageal cancer. Cancer. 2009;115:3196–203.

    Article  PubMed  Google Scholar 

  4. Kidd EA, Siegel BA, Dehdashti F, Grigsby PW. The standardized uptake value for F-18 fluorodeoxyglucose is a sensitive predictive biomarker for cervical cancer treatment response and survival. Cancer. 2007;110:1738–44.

    Article  PubMed  Google Scholar 

  5. Xie P, Li M, Zhao H, Sun X, Fu Z, Yu J, et al. 18F-FDG PET or PET–CT to evaluate prognosis for head and neck cancer: a metaanalysis. J Cancer Res Clin Oncol. 2011;137:1085–93.

    Article  PubMed  Google Scholar 

  6. Muir CS, Nectoux J. Descriptive epidemiology of malignant neoplasms of nose, nasal cavities, middle ear and accessory sinuses. Clin Otolatyngol. 1980;5:195–211.

    Article  CAS  Google Scholar 

  7. Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. Cancer staging handbooh from AJCC cancer staging mannual. 7th ed. New York: Springer; 2010. p. 39–126.

    Google Scholar 

  8. Samant S, Robbins KT, Vang M, Wan J, Robertson J. Intra-arterial cisplatin and concomitant radiation therapy followed by surgery for advanced paranasal sinus cancer. Arch Otolaryngol Head Neck Surg. 2004;130:948–55.

    Article  PubMed  Google Scholar 

  9. Kanoto M, Oda A, Hosoya T, Nemoto K, Ishida A, Nasu T, Koike S, Aoyagi M. Impact of superselective transarterial infusion therapy of high-dose cisplatin on maxillary cancer with orbital invasion. Am J Neuroradiol. 2010;31:1390–4.

    Article  CAS  PubMed  Google Scholar 

  10. Homma A, Sakashita T, Yoshida D, Onimaru R, Tsuchiya K, Suzuki F, et al. Superselective intra-arterial cisplatin infusion and concomitant radiotherapy for maxillary sinus cancer. Br J Cancer. 2013;109:2980–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Allal AS, Slosman DO, Kebdani T, Allaoua M, Lehmann W, Dulguerov P. Prediction of outcome in head-and-neck cancer patients using the standardized uptake value of 2-[18F]fluoro-2-deoxy-D-glucose. Int J Radiat Oncol Biol Phys. 2004;59:1295–300.

    Article  CAS  PubMed  Google Scholar 

  12. Tang C, Murphy JD, Khong B, La TH, Kong C, Fischbein NJ, et al. Validation that metabolic tumor volume predicts outcome in head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2012;83:1514–20.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgement

This work was supported by Grant-in-Aid for Young Scientists (B) Grant Number 25861134.

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Authors and Affiliations

  1. Department of Radiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

    Hiroshi Doi, Satoshi Yamamoto, Reiichi Ishikura & Shozo Hirota

  2. Department of Nuclear Medicine and PET Center, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

    Kazuhiro Kitajima, Kazuhito Fukushima, Yusuke Kawanaka & Miya Mouri

  3. Department of Otolaryngology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

    Tomonori Terada

  4. Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan

    Kazuma Noguchi

Authors
  1. Hiroshi Doi
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  2. Kazuhiro Kitajima
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  3. Kazuhito Fukushima
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  4. Yusuke Kawanaka
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  5. Miya Mouri
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  6. Satoshi Yamamoto
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  7. Reiichi Ishikura
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  8. Tomonori Terada
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  9. Kazuma Noguchi
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  10. Shozo Hirota
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Corresponding author

Correspondence to Kazuhiro Kitajima.

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Doi, H., Kitajima, K., Fukushima, K. et al. SUVmax on FDG-PET is a predictor of prognosis in patients with maxillary sinus cancer. Jpn J Radiol 34, 349–355 (2016). https://doi.org/10.1007/s11604-016-0531-9

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  • DOI: https://doi.org/10.1007/s11604-016-0531-9

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