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Survival Analysis of Patients Undergoing Intraoperative Contrast-enhanced Ultrasound in the Surgical Treatment of Malignant Glioma

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Abstract

Objective

Complete resection of malignant gliomas is often challenging. Our previous study indicated that intraoperative contrast-enhanced ultrasound (ICEUS) could aid in the detection of residual tumor remnants and the total removal of brain lesions. This study aimed to investigate the survival rates of patients undergoing resection with or without the use of ICEUS and to assess the impact of ICEUS on the prognosis of patients with malignant glioma.

Methods

A total of 64 patients diagnosed with malignant glioma (WHO grade HI and IV) who underwent surgery between 2012 and 2018 were included. Among them, 29 patients received ICEUS. The effects of ICEUS on overall survival (OS) and progression-free survival (PFS) of patients were evaluated. A quantitative analysis was performed to compare ICEUS parameters between gliomas and the surrounding tissues.

Results

The ICEUS group showed better survival rates both in OS and PFS than the control group. The univariate analysis revealed that age, pathology and ICEUS were significant prognostic factors for PFS, with only age being a significant prognostic factor for OS. In multivariate analysis, age and ICEUS were significant prognostic factors for both OS and PFS. The quantitative analysis showed that the intensity and transit time of microbubbles reaching the tumors were significantly different from those of microbubbles reaching the surrounding tissue.

Conclusion

ICEUS facilitates the identification of residual tumors. Age and ICEUS are prognostic factors for malignant glioma surgery, and use of ICEUS offers a better prognosis for patients with malignant glioma.

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Authors and Affiliations

  1. Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Xu Chen, Fang-ling Cheng, Dan Cao & Jian Chen

  2. Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Ya-ni Peng

  3. Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    An-yu Tao

Authors
  1. Xu Chen
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  2. Ya-ni Peng
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  3. Fang-ling Cheng
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  4. Dan Cao
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  5. An-yu Tao
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  6. Jian Chen
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Corresponding author

Correspondence to Xu Chen.

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The authors declare that they have no conflict of interest.

Additional information

This research was funded by grants from the Natural Science Foundation of Hubei Province, China (No. 2022CFB307) and the Foundation of Tongji Hospital (No. 2020JZKT292).

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Chen, X., Peng, Yn., Cheng, Fl. et al. Survival Analysis of Patients Undergoing Intraoperative Contrast-enhanced Ultrasound in the Surgical Treatment of Malignant Glioma. CURR MED SCI 44, 399–405 (2024). https://doi.org/10.1007/s11596-024-2840-z

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  • DOI: https://doi.org/10.1007/s11596-024-2840-z

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