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Infective Artery Rupture of Renal Allografts: A Single-Center Retrospective Study in China

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Abstract

Objective

This study investigated the composition of pathogenic microorganisms, clinical features, and therapeutic strategies of infective artery rupture of renal allografts in recipients receiving deceased donor (DD) kidneys.

Methods

We retrospectively studied the clinical data of the DD kidney transplant recipients with donor-associated infection at Tongji Hospital, Wuhan, China from January 1, 2015 to December 31, 2018, related recipients and corresponding donors. We collected the entire results of pathogenic microorganisms cultured from these related ruptured kidneys and then analyzed their distribution and differences.

Results

A total of 1440 kidney transplants from DD were performed in our center. The total incidence of infective artery rupture in kidney transplants was about 0.76% (11/1440), and the annual incidence ranged from 0.25% to 1.03%. The microbial culture results revealed that 11 recipients suffered from infective artery rupture and 3 recipients who accepted the kidney from same donor had the donor-associated pathogens, including 9 fungal strains (28.1%) and 23 bacterial strains (71.9%). There were 4 recipients infected with multi-drug-resistant Staphylococcus and Klebsiella pneumoniae from the above 11 recipients, of which, 10 recipients underwent graft loss, and one died of septic shock. The microbial cultures of the remaining 3 recipients who received appropriate anti-infective regimens turned negative eventually, and the patients were discharged successfully without significant complications.

Conclusion

Renal recipients with infections derived from DDs were at high risk of artery rupture, graft loss, or even death. Appropriate anti-infective treatment is essential to reduce the incidence of artery rupture and mortality.

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Authors and Affiliations

  1. Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Yu-liang Guo, Xia Lu, Lan Zhu, Dun-feng Du, Bin Liu, Zhong-hua Klaus Chen, Song Chen, Wei-jie Zhang, Zhi-shui Chen & Sheng Chang

  2. Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, 430030, China

    Yu-liang Guo, Xia Lu, Lan Zhu, Dun-feng Du, Bin Liu, Zhong-hua Klaus Chen, Song Chen, Wei-jie Zhang, Zhi-shui Chen & Sheng Chang

  3. NHC Key Laboratory of Organ Transplantation, Wuhan, 430030, China

    Yu-liang Guo, Xia Lu, Lan Zhu, Dun-feng Du, Bin Liu, Zhong-hua Klaus Chen, Song Chen, Wei-jie Zhang, Zhi-shui Chen & Sheng Chang

  4. Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, 430030, China

    Yu-liang Guo, Xia Lu, Lan Zhu, Dun-feng Du, Bin Liu, Zhong-hua Klaus Chen, Song Chen, Wei-jie Zhang, Zhi-shui Chen & Sheng Chang

Authors
  1. Yu-liang Guo
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  2. Xia Lu
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  3. Lan Zhu
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  4. Dun-feng Du
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  5. Bin Liu
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  6. Zhong-hua Klaus Chen
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  7. Song Chen
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  8. Wei-jie Zhang
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  9. Zhi-shui Chen
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  10. Sheng Chang
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Corresponding author

Correspondence to Sheng Chang.

Ethics declarations

The authors have no conflicts of interest to declare.

Author Zhi-shui CHEN is a member of the Editorial Board for Current Medical Science. The paper was handled by other editors and has undergone rigorous peer review process. Author Zhi-shui CHEN was not involved in the journal’s review of, or decision related to, this manuscript.

Additional information

This project was supported by the Natural Science Foundation of China (No. 81873511 and No. 81471587).

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Cite this article

Guo, Yl., Lu, X., Zhu, L. et al. Infective Artery Rupture of Renal Allografts: A Single-Center Retrospective Study in China. CURR MED SCI 42, 847–855 (2022). https://doi.org/10.1007/s11596-022-2557-9

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  • DOI: https://doi.org/10.1007/s11596-022-2557-9

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