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Polymorphism of OAS2 rs739901 C/A Involves the Susceptibility to EV71 Infection in Chinese Children

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Summary

This study aimed to assess the relationship of OAS2 rs739901 5,-flanking C/A polymorphisms with the susceptibility to Enterovirus-71 (EV71) infection. We investigated 294 hand-foot-mouth disease (HFMD) Chinese children with EV71 infection (165 mild cases and 129 encephalitis cases). The improved multiplex ligation detection reaction (iMLDR) technique was used to test the genotypes. In EV71-infected patients, the CA genotype distribution (P=0.007), A allele frequency (OR 1.32,95% CI 1.0–1.7, P=0.034) and CA+AA carriage frequency (P=0.003) of OAS2 rs739901 5′-flanking were obviously elevated as compared with controls, but there were no statistically significant differences between mild cases and encephalitis cases. In EV71-infected patients, the counts of white blood cells (P=0.034) and blood glucose concentrations (P=0.042) were raised in A carriers (CA+AA). Among different genotypes of encephalitis cases, the contents of cerebrospinal fluid (CSF) showed no significant differences. IFN-γ levels in EV71-infected patients were higher than those in controls (mild group vs. control group, P<0.01; encephalitis group vs. control group, P<0.01;). In encephalitis cases, IFN-γ levels were reduced (P<0.05) in A carriers compared to CC genotype, however, there were no significant differences between genotypes CA and AA (P=0.226). These findings suggest that OAS2 rs739901 5′-flanking C/A genetic polymorphisms involve the susceptibility to EV71 infection, and A allele might be a risk factor of the susceptibility to EV-71 infection.

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Acknowledgements

This study was technically supported by the Center for Genetic & Genomic Analysis, Genesky Biotechnologies Inc., Shanghai, China. The authors thank the children attending the study and their parents.

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Authors and Affiliations

  1. Department of Pediatrics, the Affiliated Hospital of Qingdao University, Qirtgdao, 266000, China

    Yu-xia Tan, Hua Lv, Pei-pei Liu, Gao-yan Wang, Ya Guo, Ye-dan Liu, Cheng-qing Yang & Zong-bo Chen

  2. Department of Pediatrics, Zibo Maternal and Child Health Hospital, Zibo, 255029, China

    Yu-xia Tan, Shun-gang Xia, Yu Wang & Li-ping Chen

  3. Department of Clinical Laboratory, the Affiliated Hospital of Qingdao University, Qingdao, 266003, China

    Hui Wang

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  1. Yu-xia Tan
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  2. Hui Wang
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  3. Hua Lv
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  5. Shun-gang Xia
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  12. Zong-bo Chen
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Correspondence to Zong-bo Chen.

Additional information

This study was supported by grants from the National Natural Science Foundation of China (No. 31171212), the Medical and Health Science and Technology Development Projects of Shandong Province (No. 2017WS379), and the Science and Technology Development Projects of Zibo City (No. 2017kj010010).

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Tan, Yx., Wang, H., Lv, H. et al. Polymorphism of OAS2 rs739901 C/A Involves the Susceptibility to EV71 Infection in Chinese Children. CURR MED SCI 38, 640–647 (2018). https://doi.org/10.1007/s11596-018-1925-y

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  • DOI: https://doi.org/10.1007/s11596-018-1925-y

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