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Clinical features and prognostic factors of small cell lung cancer: A retrospective study in 148 patients

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Abstract

To better understand the outcomes of small cell lung cancer (SCLC), we examined the clinical features and prognostic factors of SCLC in this study. A total of 148 patients who were diagnosed as having SCLC between January 2009 and December 2013 in Cancer Center of Union Hospital, Wuhan, China, were enrolled and their clinical features and prognostic factors were retrospectively analyzed. Log-rank test and Cox regression model were employed for analysis of prognostic factors. The 1- and 2-year overall survival (OS) rates were 59.7% and 25.7%, respectively, for limited disease (LD) patients whose median survival time (MST) was 16 months. The 1- and 2-year OS rates were 29.5% and 5.3%, respectively, for extensive disease (ED) patients whose MST was 10 months. The univariate analysis and multivariate analysis revealed that age, tumor stage, serum CEA and Ki-67 antigen were significantly correlated to the outcomes of SCLC, and they were significant prognostic factors for SCLC.

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Authors and Affiliations

  1. Cancer Center, Huazhong University of Science and Technology, Wuhan, 430022, China

    Qian Cai  (蔡 茜), Xi-can Gao  (高喜璨), Chun-jin Xiong  (熊春锦), Fan Tong  (童 凡), Rui-guang Zhang  (张瑞光), Gang Wu  (伍 钢) & Xiao-rong Dong  (董晓荣)

  2. Department of Oncology, Huanggang Central Hospital, Huangang, 438000, China

    Hong-lan Luo  (罗红兰)

  3. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Yu Hu  (胡 豫)

Authors
  1. Qian Cai  (蔡 茜)
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  2. Hong-lan Luo  (罗红兰)
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  3. Xi-can Gao  (高喜璨)
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  4. Chun-jin Xiong  (熊春锦)
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  5. Fan Tong  (童 凡)
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  6. Rui-guang Zhang  (张瑞光)
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  7. Yu Hu  (胡 豫)
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  8. Gang Wu  (伍 钢)
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  9. Xiao-rong Dong  (董晓荣)
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Corresponding author

Correspondence to Xiao-rong Dong  (董晓荣).

Additional information

These authors contributed equally to this work.

This study was supported by the National Natural Science Foundation of China (No. 81172595 and No. 81573090).

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Cai, Q., Luo, Hl., Gao, Xc. et al. Clinical features and prognostic factors of small cell lung cancer: A retrospective study in 148 patients. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 36, 916–922 (2016). https://doi.org/10.1007/s11596-016-1684-6

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  • DOI: https://doi.org/10.1007/s11596-016-1684-6

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