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Biologically active secondary metabolites and biotechnological applications of species of the family Chaetomiaceae (Sordariales): an updated review from 2016 to 2021

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Abstract

Fungi are eukaryotic organisms that have the ability to synthesize an enormous number of metabolites with a vast diversity of chemical structures and bioactivities. Chaetomiaceae species are a wealthy source of enzymes with diverse biotechnological and industrial applications such as PMO (polysaccharide monooxygenase), L-methioninase, β-1,3-glucanase, laccase, dextranase, lipolytic, pectinolytic, amylolytic, chitinolytic, and proteolytic enzymes. Different classes of secondary metabolites have been reported from this family are derived from various biosynthetic pathways such as alkaloids, polyketides, peptides, terpenes, and polyketide-amino acid hybrid secondary metabolites. These metabolites have attracted research interest due to their fascinating structural frameworks and bioactivities. Therefore, these compounds can be taken into account as candidates for the development of effective and novel lead compounds for medicine, as well as for plant protection. The current review represents the relevant information for Chaetomiaceae species, in particular, its new and first reported secondary metabolites and their pharmacological activities, as well as the biotechnological applications published from 2016 until the beginning of 2021.

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Abbreviations

A431:

human epidermoid carcinoma

A-549:

human lung carcinoma

AAI:

α-amylase inhibitory

ABTS:

2:2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid)

AChE:

acetylcholinesterase

AGI:

α-glucosidase inhibitory

AGS:

human gastric cancer cell line

ARTP:

atmospheric and room temperature plasma treatment

B16F10:

mouse melanoma

BEAS-2B:

human pulmonary epithelial cell line

BHT:

butylated hydroxytoluene

Caco-2:

human colorectal adenocarcinoma cell lines

CCK-8:

cell counting kit-8

CgAuNPs:

C. globosum gold nanoparticles

Con A:

concanavalin A

CT26:

murine colon carcinoma cell line

COX-2:

cyclooxygenase-2

DP:

degree of polymerization

DPPH:

2:2-diphenyl-1-picrylhydrazyl

EC50 :

half maximal effective concentration

EGF:

epidermal growth factor

EMS:

ethyl methyl sulfone

FACS:

fluorescence-activated cell sorting

H292:

human lung cancer cell

HEK 293:

human embryonic kidney

HeLa:

human cervix cancer cell line

Hep-2:

human epithelial type 2

Hep3B:

human hepatoma liver carcinoma

HepG2:

human hepatocellular liver carcinoma

HL-60:

human promyelocytic leukemia cell line

H460:

human large cell lung cancer cell

HCT-8:

human cecal adenocarcinoma cell

HO8910:

human ovarian carcinoma cell line

HT1080:

human fibrosarcoma cell line

HT29:

human colon carcinoma cell line

Huh7:

human hepatoma cell line

IC50 :

concentration required to inhibit cell growth by 50%

IL-1β:

interleukin 1 beta

IL-6:

interleukin 6

IR:

inhibition ratio

IZD:

inhibition zone diameter

K562:

chronic myelogenous leukemia

KB:

human epidermoid carcinoma cell line

L5178Y:

mouse lymphoma

LMW:

low molecular weights

LNCaP:

human prostate cancer cells

L-NMMA:

L-NG-monomethyl arginine

LOX:

lipoxygenase

LPS:

lipopolysaccharide

MABA:

microplate alamar blue assay

MCF-7:

human breast adenocarcinoma

MDA-MB-231:

human breast cancer cells

MGC-803:

human gastric cancer cell line

MIC:

minimum inhibitory concentration

MM231:

human breast cancer cell line

MMP:

mitochondrial membrane potential

MRSA:

methicillin-resistant Staph. aureus

MRSA-1:

methicillin-resistant Staph. aureus ATCC 43300

MRSA-2:

methicillin-resistant Staph. aureus CGMCC 1.12409

MTS:

3-(4:5-dimethylthiazol-2-yl)-5(3-carboxymethoxyphenyl)-2-(4-sulphophenyl)-2H-tetrazolium

MTT:

(3-(4:5-dimethylthiazol-2-yl))-2:5-diphenyl-2H-tetrazolium bromide

NB4:

human leukemia cell lines

NCI-H187:

human small cell lung cancer

NCM460:

normal colonic epithelial cell

NO:

nitric oxide

PARP:

poly (ADP-ribose) polymerase

PGE-2:

prostaglandin E2

PT:

prothrombin time

PMO:

polysaccharide monooxygenase;

RAW264.7:

murine macrophage cell line

ROS:

reactive oxygen species

SGC-7901:

human gastric cancer cells line

SMMC-7721:

human papillomavirus-related endocervical adenocarcinoma

SW1990:

human pancreatic cancer cell line

SW-480:

human colon adenocarcinoma

TB:

Mycobacterium tuberculosis

TNF-α:

tumor necrosis factor-α

TRAIL:

tumor necrosis factor–related apoptosis-inducing ligand

U-2OS:

human osteosarcoma cell line

U87MG:

human glioblastoma cell line

XO:

xanthine oxidase

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Authors and Affiliations

  1. Batterjee Medical College, P.O. Box 6231, North Obhur, Prince Abdullah Al-Faisal Street, Jeddah, 21442, Saudi Arabia

    Sabrin R. M. Ibrahim

  2. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt

    Sabrin R. M. Ibrahim

  3. Faculty of Dentistry, British University, El Sherouk City, Suez Desert Road, Cairo, 11837, Egypt

    Shaimaa G. A. Mohamed

  4. Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Ikhlas A. Sindi

  5. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Gamal A. Mohamed

  6. Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt

    Gamal A. Mohamed

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  1. Sabrin R. M. Ibrahim
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  2. Shaimaa G. A. Mohamed
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  3. Ikhlas A. Sindi
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  4. Gamal A. Mohamed
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Contributions

Conceptualization, S.R.M.I. and G.A.M.; resources, G.A.M. and S.G.A.M.; writing-original draft preparation, S.R.M.I., G.A.M., and S.G.A.M.; writing-review and editing, G.A.M. and S.R.M.I; resources, revision, and proof-reading, I.A.S.; all authors have read and agreed to the published version of the manuscript.

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Correspondence to Sabrin R. M. Ibrahim.

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Ibrahim, S.R.M., Mohamed, S.G.A., Sindi, I.A. et al. Biologically active secondary metabolites and biotechnological applications of species of the family Chaetomiaceae (Sordariales): an updated review from 2016 to 2021. Mycol Progress 20, 595–639 (2021). https://doi.org/10.1007/s11557-021-01704-w

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