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Multicentric giant cell tumor of the fourth and fifth metacarpals with lung metastases

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HAND

Abstract

Giant cell tumors of bone (GCTB) are generally benign neoplasms, but recently, some authors consider them to be low-grade malignant neoplasms because they have a relatively high rate of recurrence and at least some potential for metastases. The majority of GCTB are unifocal, and less than 1 % are multicentric. We report a rare case of a multicentric GCTB arising simultaneously in the non-dominant fourth and fifth metacarpals of a 25-year-old female. The patient underwent ray amputation of the two involved digits, and the surgical margins were histologically negative for tumor. The tumor had the classic histologic appearance of a benign GCTB. A year after the amputation, the patient developed pulmonary metastasis which was treated with pulmonary lobe resection. She is currently over 2.5 years postsurgical treatment of the primary lesion with no evidence of local recurrence or distant metastasis.

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References

  1. Arroud M, Afifi MA, Chbani L, Bouabdallah Y. Giant-cell tumor of the fourth metacarpal bone in children: case report. J Pediatr Orthop B. 2010;19(1):86–9.

    Article  PubMed  Google Scholar 

  2. Athanasian EA, Wold LE, Amadio PC. Giant cell tumors of the bones of the hand. J Hand Surg [Am]. 1997;22(1):91–8.

    Article  CAS  Google Scholar 

  3. Averill RM, Smith RJ, Campbell CJ. Giant-cell tumors of the bones of the hand. J Hand Surg [Am]. 1980;5(1):39–50.

    Article  CAS  Google Scholar 

  4. Bertoni F, Bacchini P, Staals EL. Malignancy in giant cell tumor of bone. Cancer. 2003;97(10):2520–9.

    Article  PubMed  Google Scholar 

  5. Bertoni F, Present D, Enneking WE. Giant cell tumor of bone with pulmonary metastases. J Bone Joint Surg Am. 1985;67(6):890–900.

    CAS  PubMed  Google Scholar 

  6. Campanacci M, Baldini N, Boriani S, Sudanese A. Giant cell tumor of bone. J Bone Joint Surg Am. 1987;69(1):106–14.

    CAS  PubMed  Google Scholar 

  7. Dhillon MS, Prasad P. Multicentric giant cell tumour of bone. Acta Orthop Belg. 2007;73(3):289–99.

    PubMed  Google Scholar 

  8. Fletcher CDM, Unni KK, Mertens F, editors. World Health Organization classification of tumours: pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press; 2002. p. 310–3.

    Google Scholar 

  9. Hoch BL, Inwards C, Sundaram M, Rosenberg AE. Multicentric giant cell tumor of bone: clinicopathologic analysis of thirty cases. J Bone Joint Surg Am. 2006;88(9):1998–2008.

    Article  PubMed  Google Scholar 

  10. McDonald DJ, Sim FH, McLeod RA, Dahlin DC. Giant-cell tumor of bone. J Bone Joint Surg Am. 1986;68(2):235–42.

    CAS  PubMed  Google Scholar 

  11. Minhas MS, Mehboob G, Ansari I. Giant cell tumours in hand bones. J Coll Physicians Surg Pak. 2010;20(7):460–3.

    PubMed  Google Scholar 

  12. Moon JC, Kim SR, Chung MJ, Lee YC. Multiple pulmonary metastases from giant cell tumor of the hand. Am J Med Sci. 2012;343(2):171–3.

    Article  PubMed  Google Scholar 

  13. Patradul A, Kitidumrongsook P, Parkpian V, Ngarmukos C. Allograft replacement in giant cell tumour of the hand. Hand Surg. 2001;6(1):59–65.

    Article  CAS  PubMed  Google Scholar 

  14. Rock MG, Pritchard DJ, Unni KK. Metastases from histologically benign giant-cell tumor of bone. J Bone Joint Surg Am. 1984;66(2):269–74.

    CAS  PubMed  Google Scholar 

  15. Rosai J. Rosai and Ackerman's surgical pathology. 10th ed. Edinburgh: Mosby Elsevier; 2011. p. 2043–6.

    Google Scholar 

  16. Sanerkin NG. Malignancy, aggressiveness, and recurrence in giant cell tumor of bone. Cancer. 1980;46(7):1641–9.

    Article  CAS  PubMed  Google Scholar 

  17. Singhal RM, Mukhopadhyay S, Tanwar RK, Pant GS, Julka PK. Case report: giant cell tumour of metacarpals: report of three cases. Br J Radiol. 1994;67(796):408–10.

    Article  CAS  PubMed  Google Scholar 

  18. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev. 1999;20(3):345–57.

    Article  CAS  PubMed  Google Scholar 

  19. Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, et al. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol. 2010;11(3):275–80.

    Article  CAS  PubMed  Google Scholar 

  20. Thomas DM, Skubitz T. Giant cell tumors of bone. Curr Opin Oncol. 2009;21(4):338–44.

    Article  PubMed  Google Scholar 

  21. Wülling M, Engels C, Jesse N, Werner M, Delling G, Kaiser E. The nature of giant cell tumor of bone. J Cancer Res Clin Oncol. 2001;127(8):467–74.

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

Nash H. Naam declares that he has no conflict of interest.

Steven L. Jones declares that he has no conflict of interest.

Justin Floyd declares that he has no conflict of interest.

Esat I. Memisoglu declares that he has no conflict of interest.

Statement on human rights

We hereby testify that all procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008. Informed consent was obtained from the patient for being included in the study.

Informed consent

A written informed consent for publication was obtained from the patient mentioned in this case report.

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Authors and Affiliations

  1. Department of Plastic and Reconstructive Surgery, Southern Illinois Hand Center, Southern Illinois University, Effingham, IL, USA

    Nash H. Naam

  2. 901 Medical Park Drive, Suite 100, Effingham, IL, 62401, USA

    Nash H. Naam

  3. Department of Pathology, St. Anthony’s Memorial Hospital, Effingham, IL, USA

    Steven L. Jones

  4. Cancer Care Specialists of Central Illinois, Effingham, IL, USA

    Justin Floyd

  5. Washington University School of Medicine, St. Louis, MO, USA

    Justin Floyd

  6. Department of Radiology, St. Anthony’s Memorial Hospital, Effingham, IL, USA

    Esat I. Memisoglu

Authors
  1. Nash H. Naam
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  2. Steven L. Jones
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  3. Justin Floyd
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  4. Esat I. Memisoglu
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Correspondence to Nash H. Naam.

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Naam, N.H., Jones, S.L., Floyd, J. et al. Multicentric giant cell tumor of the fourth and fifth metacarpals with lung metastases. HAND 9, 389–392 (2014). https://doi.org/10.1007/s11552-013-9574-x

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  • DOI: https://doi.org/10.1007/s11552-013-9574-x

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