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Inducing therapeutic hypothermia via selective brain cooling: a finite element modeling analysis

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Abstract

Therapeutic hypothermia is a treatment method to reduce brain injuries after stroke, especially for cerebral ischemia. This study investigates in the temperature distribution of the head within selective brain cooling (SBC). Anatomically accurate geometries based on CT images of head and neck regions are used to develop the 3D geometry and physical model for the finite element modeling. Two cooling methods, the direct head surface cooling strategy and the combination cooling strategy of both head and neck, are evaluated to analyze the inducing hypothermia. The results show that for direct head surface cooling, the scalp and skull temperatures decrease significantly as the blood perfusion rate is constrained, but it is hard to affect the brain core temperature. To achieve a lower cerebral temperature, combination cooling strategy of both head and neck is an effective method in improving deep brain cooling. In normal condition, the cerebral temperature is reduced by about 0.12 °C in 60 min of hypothermia, while the temperature drop is approximately 0.98 °C in ischemic condition.

In this study, the 3D geometry of the head and carotid artery model based on the computed tomography (CT) were derived separately and the corresponding investigations were conducted to validate the reliability of the model. Direct head surface cooling strategy and the combination cooling strategy of both the head and neck were numerically researched.

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Funding

The study is supported by China Postdoctoral Science Foundation (No. 2018 M640797), the open fund of Hubei key laboratory of mechanical transmission and manufacturing engineering in Wuhan University of Science and Technology (No. 2017A05), and the young researcher project funded by South China Normal University (No. 17KJ14).

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Authors and Affiliations

  1. Shenzhen University, Nanhai Ave 3688, Shenzhen, 518060, People’s Republic of China

    Lu Yin

  2. National Center for International Research on Green Optoelectronics, South China Normal University, Waihuan West Road 378, Guangzhou, 510006, People’s Republic of China

    Hongwei Jiang, Weiwei Zhao & Hui Li

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  1. Lu Yin
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  4. Hui Li
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Correspondence to Hui Li.

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Yin, L., Jiang, H., Zhao, W. et al. Inducing therapeutic hypothermia via selective brain cooling: a finite element modeling analysis. Med Biol Eng Comput 57, 1313–1322 (2019). https://doi.org/10.1007/s11517-019-01962-7

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