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Self-emulsifying Transparent Nanoemulsion to Improve 9'-cis-Bixin Photo Stability in Aqueous Solution by Tween 20 and Lecithin

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Abstract

Aqueous and photo stability of bixin are challenges in practical applications. Herein, transparent nanoemulsion can be self-emulsified to improve 9'-cis-bixin aqueous and photo stability. The 0.25 g carvacrol with 0.5% w/w 9'-cis-bixin, 2.08 g 12-% soybean lecithin, 2.25 g Tween 20, and 0.42 g water were mixed and stored overnight to fabricate transparent oil-in-water (O/W) nanoemulsion. The O/W nanoemulsion droplets had an average dimeter of 12.03 nm and equivalent spherical diameter of 6.78 nm. Photo stability of 9'-cis-bixin was improved after encapsulating in nanoemulsion droplets, demonstrated by significant improvement of 9'-cis-bixin degradation rate constant under ultraviolet. Nanoemulsion droplets significantly improved cell uptake of 9'-cis-bixin especially at the first 15 min after cocultivation of Caco-2 cells and 9'-cis-bixin encapsulated nanoemulsion. This study provides a comprehensive understanding of bixin protection by nanoemulsion fabricated by a self-emulsification method with potential cellular uptake.

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Acknowledgements

All authors sincerely appreciate Professor Qixin Zhong at University of Tennessee Knoxville, USA for his very professional knowledge in this study and language improvement. Yongguang Guan acknowledges the financial supported by the National Natural Science Foundation of China (No. 31871845) for this work.

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Authors and Affiliations

  1. Department of Food Science and Technology, Shanghai Jiao Tong University, Shanghai, 200240, China

    Danyu Lv, Chenming Dai, Muyun Wang & Yongguang Guan

  2. Department of Food Science, University of Tennessee, Knoxville, TN, 37996, USA

    Huaiqiong Chen

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  1. Danyu Lv
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  2. Chenming Dai
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Lv, D., Dai, C., Wang, M. et al. Self-emulsifying Transparent Nanoemulsion to Improve 9'-cis-Bixin Photo Stability in Aqueous Solution by Tween 20 and Lecithin. Food Biophysics 17, 545–556 (2022). https://doi.org/10.1007/s11483-022-09741-y

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