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Quality of Life Predicts Survival and Hospitalisation in a Heart Failure Portuguese Population

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Abstract

The aim of this study was to examine whether quality of life (QoL) is an independent predictor of death and hospitalization for cardiovascular (CV) causes in patients with heart failure (HF). A 6- year prospective study was conducted on 130 outpatients with HF who were recruited from a cardiology service at S. João Hospital. Generic QoL was measured with the Medical Outcome Study 36-item Short Form Survey (SF-36), disease-specific QoL was measured with the Kansas City Cardiomyopathy Questionnaire (KCCQ) and the Beck Depression Inventory Scale (BDI-II) was used to screen for depressive symptoms (DS). Logistic regression and multinomial logistic regression analysis were used to evaluate the independent prognostic value of QoL measures on all cause mortality and hospitalization for CV causes after adjustment for clinical risk factors. During the follow-up 48 % of the participants died for all causes and 38 % were hospitalized for CV causes. Both generic and disease-specific QoL instruments were predictive of mortality and hospitalization on univariate analysis. After adjustment for prognostic factors such as DS, age, gender, B-type natriuretic peptide (BNP) levels, renal insufficiency and functional class NHYA only the summary clinical domain of KCCQ remained predictive of mortality. With respect to hospitalization for CV causes remained the predictive power: the summary clinical domain and the self-efficacy domains of KCCQ and the physical health domain of SF-36. Worse QoL is associated with all- cause death and hospitalization for CV causes in patients with HF and its impact persists over 6 years.

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Authors and Affiliations

  1. Cardiovascular Research Unit, Faculty of Medicine, University of Porto, Porto, Portugal

    Sónia Ramos, Joana Prata, Francisco Rocha-Gonçalves & Paulo Bettencourt

  2. Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal

    Rui Coelho

  3. Department of Clinical Neuroscience and Mental Health, Faculty of Medicine, University of Porto, Porto, Portugal

    Rui Coelho

  4. Rua Cândido Beirante n° 6, 4715-269, Braga, Portugal

    Sónia Ramos

Authors
  1. Sónia Ramos
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  2. Joana Prata
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  3. Francisco Rocha-Gonçalves
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  4. Paulo Bettencourt
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  5. Rui Coelho
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Correspondence to Sónia Ramos.

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All procedures performed in this study were in acordance with the ethical standards of the institution and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in this study.

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Ramos, S., Prata, J., Rocha-Gonçalves, F. et al. Quality of Life Predicts Survival and Hospitalisation in a Heart Failure Portuguese Population. Applied Research Quality Life 12, 35–48 (2017). https://doi.org/10.1007/s11482-016-9449-8

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  • DOI: https://doi.org/10.1007/s11482-016-9449-8

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