Skip to main content

Advertisement

SpringerLink
Log in

Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules

  • INVITED REVIEW
  • Published:
Journal of Neuroimmune Pharmacology Aims and scope Submit manuscript

Abstract

Global treatment of drug addiction costs society billions of dollars annually, but current psychopharmacological therapies have not been successful at desired rates. The increasing number of individuals suffering from substance abuse has turned attention to what makes some people more vulnerable to drug addiction than others. One personality trait that stands out as a contributing factor is novelty seeking. Novelty seeking, affected by both genetic and environmental factors, is defined as the tendency to desire novel stimuli and environments. It can be measured in humans through questionnaires and in rodents using behavioral tasks. On the behavioral level, both human and rodent studies demonstrate that high novelty seeking can predict the initiation of drug use and a transition to compulsive drug use and create a propensity to relapse. These predictions are valid for several drugs of abuse, such as alcohol, nicotine, cocaine, amphetamine, and opiates. On the molecular level, both novelty seeking and addiction are modulated by the central reward system in the brain. Dopamine is the primary neurotransmitter involved in the overlapping neural substrates of both parameters. In sum, the novelty-seeking trait can be valuable for predicting individual vulnerability to drug addiction and for generating successful treatment for patients with substance abuse disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  • Agrawal A, Lynskey MT (2008) Are there genetic influences on addiction: evidence from family, adoption and twin studies. Addiction 103:1069–1081

    Article  PubMed  Google Scholar 

  • Agrawal A, Verweij KJ, Gillespie NA, Heath AC, Lessov-Schlaggar CN, Martin NG, Nelson EC, Slutske WS, Whitfield JB, Lynskey MT (2012) The genetics of addiction-a translational perspective. Transl Psychiatry 2:e140

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, Dent R, Cohen J, McPherson R, Pennacchio LA (2007) Medical sequencing at the extremes of human body mass. Am J Hum Genet 80:779–791

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ambrosio E, Goldberg SR, Elmer GI (1995) Behavior genetic investigation of the relationship between spontaneous locomotor activity and the acquisition of morphine self-administration behavior. Behav Pharmacol 6:229–237

    Article  CAS  PubMed  Google Scholar 

  • Andrucci GL, Archer RP, Pancoast DL, Gordon RA (1989) The relationship of mmpi and sensation seeking scales to adolescent drug-use. J Pers Assess 53:253–266

    Article  CAS  PubMed  Google Scholar 

  • Arnett J (1994) Sensation seeking - a new conceptualization and a new scale. Personal Individ Differ 16:289–296

    Article  Google Scholar 

  • Ballon N, Brunault P, Cortese S (2015) Sensation seeking and cocaine dependence in adults with reported childhood ADHD. J Atten Disord 19:335–342

    Article  PubMed  Google Scholar 

  • Bardo MT, Donohew RL, Harrington NG (1996) Psychobiology of novelty seeking and drug seeking behavior. Behav Brain Res 77:23–43

    Article  CAS  PubMed  Google Scholar 

  • Belin D, Deroche-Gamonet V (2012) Responses to novelty and vulnerability to cocaine addiction: contribution of a multi-symptomatic animal model. Cold Spring Harb Perspect Med 2

  • Bernheim A, Halfon O, Boutrel B (2013) Controversies about the enhanced vulnerability of the adolescent brain to develop addiction. Front Pharmacol 4:118

    Article  PubMed  PubMed Central  Google Scholar 

  • Bevins RA, Klebaur JE, Bardo MT (1997) Individual differences in response to novelty, amphetamine-induced activity and drug discrimination in rats. Behav Pharmacol 8:113–123

    CAS  PubMed  Google Scholar 

  • Blanchard MM, Mendelsohn D, Stamp JA (2009) The HR/LR model: further evidence as an animal model of sensation seeking. Neurosci Biobehav Rev 33:1145–1154

    Article  PubMed  Google Scholar 

  • Blum K, Chen AL, Giordano J, Borsten J, Chen TJ, Hauser M, Simpatico T, Femino J, Braverman ER, Barh D (2012) The addictive brain: all roads lead to dopamine. J Psychoactive Drugs 44:134–143

    Article  PubMed  Google Scholar 

  • Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs AH, Cohn JB (1990) Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 263:2055–2060

    Article  CAS  PubMed  Google Scholar 

  • Boissier JR, Simon P (1962) The exploration reaction in the mouse. Preliminary note. Therapie 17:1225–1232

    CAS  PubMed  Google Scholar 

  • Bolos AM, Dean M, Lucasderse S, Ramsburg M, Brown GL, Goldman D (1990) Population and pedigree studies reveal a lack of association between the dopamine-D2 receptor gene and alcoholism. Jama-J Am Med Assoc 264:3156–3160

    Article  CAS  Google Scholar 

  • Bookman EB, Taylor RE, Adams-Campbell L, Kittles RA (2002) DRD4 promoter SNPs and gender effects on extraversion in African Americans. Mol Psychiatry 7:786–789

    Article  CAS  PubMed  Google Scholar 

  • Brown GR, Nemes C (2008) The exploratory behaviour of rats in the hole-board apparatus: is head-dipping a valid measure of neophilia? Behav Process 78:442–448

    Article  Google Scholar 

  • Burns L (2014) World drug report 2013 united nations office on drugs and crime. Drug Alcohol Rev 33:216–216

    Article  Google Scholar 

  • Cagetti E, Liang J, Spigelman I, Olsen RW (2003) Withdrawal from chronic intermittent ethanol treatment changes subunit composition, reduces synaptic function, and decreases behavioral responses to positive allosteric modulators of GABAA receptors. Mol Pharmacol 63:53–64

    Article  CAS  PubMed  Google Scholar 

  • Cain ME, Saucier DA, Bardo MT (2005) Novelty seeking and drug use: contribution of an animal model. Exp Clin Psychopharmacol 13:367–375

    Article  CAS  PubMed  Google Scholar 

  • Carton S, Le Houezec J, Lagrue G, Jouvent R (2000) Relationships between sensation seeking and emotional symptomatology during smoking cessation with nicotine patch therapy. Addict Behav 25:653–662

    Article  CAS  PubMed  Google Scholar 

  • Chefer VI, Zakharova I, Shippenberg TS (2003) Enhanced responsiveness to novelty and cocaine is associated with decreased basal dopamine uptake and release in the nucleus accumbens: quantitative microdialysis in rats under transient conditions. J Neurosci 23:3076–3084

    CAS  PubMed  Google Scholar 

  • Chen C, Moyzis R, Dong Q, He Q, Zhu B, Li J, Li H, Lessard J (2011) Sex modulates the associations between the COMT gene and personality traits. Neuropsychopharmacology 36:1593–1598

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cloninger CR (1986) A unified biosocial theory of personality and its role in the development of anxiety states. Psychiatr Dev 4:167–226

    CAS  PubMed  Google Scholar 

  • Cloninger CR (1987) Neurogenetic adaptive mechanisms in alcoholism. Science 236:410–416

    Article  CAS  PubMed  Google Scholar 

  • Cloninger CR, Przybeck TR, Svrakic DM (1991) The tridimensional personality questionnaire: U.S. normative data. Psychol Rep 69:1047–1057

    Article  CAS  PubMed  Google Scholar 

  • Cloninger CR, Svrakic DM, Przybeck TR (1993) A psychobiological model of temperament and character. Arch Gen Psychiatry 50:975–990

    Article  CAS  PubMed  Google Scholar 

  • Comeau N, Stewart SH, Loba P (2001) The relations of trait anxiety, anxiety sensitivity, and sensation seeking to adolescents' motivations for alcohol, cigarette, and marijuana use. Addict Behav 26:803–825

    Article  CAS  PubMed  Google Scholar 

  • Compton PA, Anglin MD, Khalsa-Denison ME, Paredes A (1996) The D2 dopamine receptor gene, addiction, and personality: clinical correlates in cocaine abusers. Biol Psychiatry 39:302–304

    Article  CAS  PubMed  Google Scholar 

  • Crawford CA, Der-Ghazarian T, Britt CE, Varela FA, Kozanian OO (2013) Novelty-induced conditioned place preference, sucrose preference, and elevated plus maze behavior in adult rats after repeated exposure to methylphenidate during the preweanling period. Behav Brain Res 246:29–35

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Crettol S, Besson J, Croquette-Krokar M, Hammig R, Gothuey I, Monnat M, Deglon JJ, Preisig M, Eap CB (2008) Association of dopamine and opioid receptor genetic polymorphisms with response to methadone maintenance treatment. Prog Neuro-Psychopharmacol Biol Psychiatry 32:1722–1727

    Article  CAS  Google Scholar 

  • Cummings JA, Gowl BA, Westenbroek C, Clinton SM, Akil H, Becker JB (2011) Effects of a selectively bred novelty-seeking phenotype on the motivation to take cocaine in male and female rats. Biol Sex Differ 2:3

    Article  PubMed  PubMed Central  Google Scholar 

  • Davis BA, Clinton SM, Akil H, Becker JB (2008) The effects of novelty-seeking phenotypes and sex differences on acquisition of cocaine self-administration in selectively bred high-responder and low-responder rats. Pharmacol Biochem Behav 90:331–338

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dervaux A, Laqueille X, Bourdel MC, Olie JP, Krebs MO (2010) Impulsivity and sensation seeking in alcohol abusing patients with schizophrenia. Front Psychiatry 1:135

    Article  PubMed  PubMed Central  Google Scholar 

  • Ebstein RP (2006) The molecular genetic architecture of human personality: beyond self-report questionnaires. Mol Psychiatry 11:427–445

    Article  CAS  PubMed  Google Scholar 

  • Eichhammer P, Sand PG, Stoertebecker P, Langguth B, Zowe M, Hajak G (2005) Variation at the DRD4 promoter modulates extraversion in caucasians. Mol Psychiatry 10:520–522

    Article  CAS  PubMed  Google Scholar 

  • Ersche KD, Turton AJ, Pradhan S, Bullmore ET, Robbins TW (2010) Drug addiction endophenotypes: impulsive versus sensation-seeking personality traits. Biol Psychiatry 68:770–773

    Article  PubMed  PubMed Central  Google Scholar 

  • Evenden JL (1999) Varieties sf impulsivity. Psychopharmacology 146:348–361

    Article  CAS  PubMed  Google Scholar 

  • Evren C, Durkaya M, Evren B, Dalbudak E, Cetin R (2012) Relationship of relapse with impulsivity, novelty seeking and craving in male alcohol-dependent inpatients. Drug Alcohol Rev 31:81–90

    Article  PubMed  Google Scholar 

  • Faingold C, Li Y, Evans MS (2000) Decreased GABA and increased glutamate receptor-mediated activity on inferior colliculus neurons in vitro are associated with susceptibility to ethanol withdrawal seizures. Brain Res 868:287–295

    Article  CAS  PubMed  Google Scholar 

  • Fairbanks LA, Bailey JN, Breidenthal SE, Laudenslager ML, Kaplan JR, Jorgensen MJ (2011) Environmental stress alters genetic regulation of novelty seeking in vervet monkeys. Genes Brain Behav 10:683–688

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Finn PR, Mazas CA, Justus AN, Steinmetz J (2002) Early-onset alcoholism with conduct disorder: go/no go learning deficits, working memory capacity, and personality. Alcohol Clin Exp Res 26:186–206

    Article  PubMed  Google Scholar 

  • Flagel SB, Robinson TE, Clark JJ, Clinton SM, Watson SJ, Seeman P, Phillips PE, Akil H (2010) An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction. Neuropsychopharmacology 35:388–400

    Article  PubMed  Google Scholar 

  • Flagel SB, Waselus M, Clinton SM, Watson SJ, Akil H (2014) Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty. Neuropharmacology 76 Pt B:425–436.

  • Fumagalli F, Bedogni F, Maragnoli ME, Gennarelli M, Perez J, Racagni G, Riva MA (2003) Dopaminergic D2 receptor activation modulates FGF-2 gene expression in rat prefrontal cortex and hippocampus. J Neurosci Res 74:74–80

    Article  CAS  PubMed  Google Scholar 

  • Golimbet VE, Gritsenko IK, Alfimova MV, Ebstein RP (2005) Polymorphic markers of the dopamine D4 receptor gene promoter region and personality traits in mentally healthy individuals from the Russian population. Russ J Genet 41:789–793

    Article  CAS  Google Scholar 

  • Gomez H, Lluch JM, Masgrau L (2012) Essential role of glutamate 317 in galactosyl transfer by alpha3GalT: a computational study. Carbohydr Res 356:204–208

    Article  CAS  PubMed  Google Scholar 

  • Greenwood TA, Badner JA, Byerley W, Keck PE, McElroy SL, Remick RA, Dessa Sadovnick A, Kelsoe JR (2013) Heritability and linkage analysis of personality in bipolar disorder. J Affect Disord 151:748–755

    Article  PubMed  PubMed Central  Google Scholar 

  • Gulley JM, Hoover BR, Larson GA, Zahniser NR (2003) Individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics, and the dopamine transporter. Neuropsychopharmacology 28:2089–2101

    CAS  PubMed  Google Scholar 

  • Han C, McGue MK, Iacono WG (1999) Lifetime tobacco, alcohol and other substance use in adolescent Minnesota twins: univariate and multivariate behavioral genetic analyses. Addiction 94:981–993

    Article  CAS  PubMed  Google Scholar 

  • Hascoet M, Bourin M, Dhonnchadha BAN (2001) The mouse light-dark paradigm: a review. Prog Neuro-Psychopharmacol Biol Psychiatry 25:141–166

    Article  CAS  Google Scholar 

  • Hawkins JD, Catalano RF, Miller JY (1992) Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood - implications for substance-abuse prevention. Psychol Bull 112:64–105

    Article  CAS  PubMed  Google Scholar 

  • Heck A, Lieb R, Ellgas A, Pfister H, Lucae S, Roeske D, Putz B, Muller-Myhsok B, Uhr M, Holsboer F, Ising M (2009) Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking. Genes Brain Behav 8:464–472

    Article  CAS  PubMed  Google Scholar 

  • Hiroi N, Agatsuma S (2005) Genetic susceptibility to substance dependence. Mol Psychiatry 10:336–344

    Article  CAS  PubMed  Google Scholar 

  • Hooks MS, Jones GH, Smith AD, Neill DB, Justice Jr JB (1991) Response to novelty predicts the locomotor and nucleus accumbens dopamine response to cocaine. Synapse 9:121–128

  • Hooks MS, Juncos JL, Justice Jr JB, Meiergerd SM, Povlock SL, Schenk JO, Kalivas PW (1994) Individual locomotor response to novelty predicts selective alterations in D1 and D2 receptors and mRNAs. J Neurosci 14:6144–6152

  • Hosak L (2007) Role of the COMT gene Val158Met polymorphism in mental disorders: a review. Eur Psychiatry 22:276–281

    Article  PubMed  Google Scholar 

  • Hosak L, Libiger J, Cizek J, Beranek M, Cermakova E (2006) The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: preliminary results. Neuro Endocrinol Lett 27:799–802

    CAS  PubMed  Google Scholar 

  • Howard MO, Kivlahan D, Walker RD (1997) Cloninger's tridimensional theory of personality and psychopathology: applications to substance use disorders. J Stud Alcohol 58:48–66

    Article  CAS  PubMed  Google Scholar 

  • Ismael F, Baltieri DA (2014) Role of personality traits in cocaine craving throughout an outpatient psychosocial treatment program. Rev Bras Psiquiatr 36:24–31

    Article  PubMed  Google Scholar 

  • Kahler CW, Spillane NS, Metrik J, Leventhal AM, Monti PM (2009) Sensation seeking as a predictor of treatment compliance and smoking cessation treatment outcomes in heavy social drinkers. Pharmacol Biochem Behav 93:285–290

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kalivas PW, Volkow ND (2011) New medications for drug addiction hiding in glutamatergic neuroplasticity. Mol Psychiatry 16:974–986

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kandel DB, Wu P, Davies M (1994) Maternal smoking during pregnancy and smoking by adolescent daughters. Am J Public Health 84:1407–1413

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kang JI, Kim SJ, Song YY, Namkoong K, An SK (2013) Genetic influence of COMT and BDNF gene polymorphisms on resilience in healthy college students. Neuropsychobiology 68:174–180

    Article  CAS  PubMed  Google Scholar 

  • Kelly TH, Robbins G, Martin CA, Fillmore MT, Lane SD, Harrington NG, Rush CR (2006) Individual differences in drug abuse vulnerability: d-amphetamine and sensation-seeking status. Psychopharmacology 189:17–25

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kempton MJ, Haldane M, Jogia J, Christodoulou T, Powell J, Collier D, Williams SC, Frangou S (2009) The effects of gender and COMT Val158Met polymorphism on fearful facial affect recognition: a fMRI study. Int J Neuropsychopharmacol 12:371–381

    Article  CAS  PubMed  Google Scholar 

  • Kendler KS, Jacobson KC, Prescott CA, Neale MC (2003) Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. Am J Psychiatry 160:687–695

    Article  PubMed  Google Scholar 

  • Khan AA, Jacobson KC, Gardner CO, Prescott CA, Kendler KS (2005) Personality and comorbidity of common psychiatric disorders. Br J Psychiatry 186:190–196

    Article  PubMed  Google Scholar 

  • Kirby LG, Zeeb FD, Winstanley CA (2011) Contributions of serotonin in addiction vulnerability. Neuropharmacology 61:421–432

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Koob GF (2000) Neurobiology of addiction. Toward the Development of new Therapies. Annals of the New York Academy of Sciences 909:170–185

    Article  CAS  PubMed  Google Scholar 

  • Koob GF (2006) The neurobiology of addiction: a neuroadaptational view relevant for diagnosis. Addiction 101(Suppl 1):23–30

    Article  PubMed  Google Scholar 

  • Krebs RM, Heipertz D, Schuetze H, Duzel E (2011) Novelty increases the mesolimbic functional connectivity of the substantia nigra/ventral tegmental area (SN/VTA) during reward anticipation: evidence from high-resolution fMRI. NeuroImage 58:647–655

    Article  CAS  PubMed  Google Scholar 

  • Lawford BR, Young RM, Noble EP, Sargent J, Rowell J, Shadforth S, Zhang XX, Ritchie T (2000) The D-2 dopamine receptor al allele and opioid dependence: association with heroin use and response to methadone treatment. Am J Med Genet 96:592–598

    Article  CAS  PubMed  Google Scholar 

  • Leccese AP, Lyness WH (1984) The effects of putative 5-hydroxytryptamine receptor active agents on D-amphetamine self-administration in controls and rats with 5,7-dihydroxytryptamine median forebrain-bundle lesions. Brain Res 303:153–162

    Article  CAS  PubMed  Google Scholar 

  • Leyton M, Boileau I, Benkelfat C, Diksic M, Baker G, Dagher A (2002a) Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[11C]raclopride study in healthy men. Neuropsychopharmacology 27:1027–1035

    Article  CAS  PubMed  Google Scholar 

  • Leyton M, Boileau I, Benkelfat C, Diksic M, Baker G, Dagher A (2002b) Amphetamine-induced increases in extracellular dopamine, drug wanting, and novelty seeking: a PET/[C-11]raclopride study in healthy men. Neuropsychopharmacology 27:1027–1035

    Article  CAS  PubMed  Google Scholar 

  • Li MD, Cheng R, Ma JZ, Swan GE (2003) A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female adult twins. Addiction 98:23–31

    Article  PubMed  Google Scholar 

  • Lim SS et al (2012) A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the global burden of disease study 2010. Lancet 380:2224–2260

    Article  PubMed  PubMed Central  Google Scholar 

  • Long JC, Knowler WC, Hanson RL, Robin RW, Urbanek M, Moore E, Bennett PH, Goldman D (1998) Evidence for genetic linkage to alcohol dependence on chromosomes 4 and 11 from an autosome-wide scan in an American Indian population. Am J Med Genet 81:216–221

    Article  CAS  PubMed  Google Scholar 

  • Lu RB, Ko HC, Chang FM, Castiglione CM, Schoolfield G, Pakstis AJ, Kidd JR, Kidd KK (1996) No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct taiwanese populations. Biol Psychiatry 39:419–429

    Article  CAS  PubMed  Google Scholar 

  • Mahler SV, Vazey EM, Beckley JT, Keistler CR, McGlinchey EM, Kaufling J, Wilson SP, Deisseroth K, Woodward JJ, Aston-Jones G (2014) Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking. Nat Neurosci 17:577–U136

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mahoney JJ, Thompson-Lake DGY, Cooper K, Verrico CD, Newton TF, De La Garza R (2015) A comparison of impulsivity, depressive symptoms, lifetime stress and sensation seeking in healthy controls versus participants with cocaine or methamphetamine use disorders. J Psychopharmacol 29:50–56

    Article  CAS  PubMed  Google Scholar 

  • Manzo L, Gomez MJ, Callejas-Aguilera JE, Donaire R, Sabariego M, Fernandez-Teruel A, Canete A, Blazquez G, Papini MR, Torres C (2014) Relationship between ethanol preference and sensation/novelty seeking. Physiol Behav 133:53–60

    Article  CAS  PubMed  Google Scholar 

  • Marinelli M, White FJ (2000) Enhanced vulnerability to cocaine self-administration is associated with elevated impulse activity of midbrain dopamine neurons. J Neurosci 20:8876–8885

    CAS  PubMed  Google Scholar 

  • Matthes HW, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, Befort K, Dierich A, Le Meur M, Dolle P, Tzavara E, Hanoune J, Roques BP, Kieffer BL (1996) Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 383:819–823

    Article  CAS  PubMed  Google Scholar 

  • Meszaros K, Lenzinger E, Hornik K, Fureder T, Willinger U, Fischer G, Schonbeck G, Aschauer HN (1999) The tridimensional personality questionnaire as a predictor of relapse in detoxified alcohol dependents. The european fluvoxamine in alcoholism study group. Alcohol Clin Exp Res 23:483–486

    Article  CAS  PubMed  Google Scholar 

  • Meyer AC, Rahman S, Charnigo RJ, Dwoskin LP, Crabbe JC, Bardo MT (2010) Genetics of novelty seeking, amphetamine self-administration and reinstatement using inbred rats. Genes Brain Behav 9:790–798

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Montag C, Jurkiewicz M, Reuter M (2012) The role of the catechol-O-methyltransferase (COMT) gene in personality and related psychopathological disorders. CNS Neurol Disord Drug Targets 11:236–250

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nadal R, Armario A, Janak PH (2002) Positive relationship between activity in a novel environment and operant ethanol self-administration in rats. Psychopharmacology 162:333–338

    Article  CAS  PubMed  Google Scholar 

  • Nakamura Y, Ito Y, Aleksic B, Kushima I, Yasui-Furukori N, Inada T, Ono Y, Ozaki N (2010) Influence of HTR2A polymorphisms and parental rearing on personality traits in healthy Japanese subjects. J Hum Genet 55:838–841

    Article  PubMed  Google Scholar 

  • Nesil T, Kanit L, Li MD, Pogun S (2013) Nine generations of selection for high and low nicotine intake in outbred Sprague-Dawley rats. Behav Genet 43:436–444

    Article  PubMed  Google Scholar 

  • Netter P, Hennig J, Roed IS (1996) Serotonin and dopamine as mediators of sensation seeking behavior. Neuropsychobiology 34:155–165

    Article  CAS  PubMed  Google Scholar 

  • Okuyama Y, Ishiguro H, Nankai M, Shibuya H, Watanabe A, Arinami T (2000) Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait. Mol Psychiatry 5:64–69

    Article  CAS  PubMed  Google Scholar 

  • Pelloux Y, Costentin J, Duterte-Boucher D (2015) Differential involvement of anxiety and novelty preference levels on oral ethanol consumption in rats. Psychopharmacology (Berl).

  • Piazza PV, Deminiere JM, Le Moal M, Simon H (1989) Factors that predict individual vulnerability to amphetamine self-administration. Science 245:1511–1513

    Article  CAS  PubMed  Google Scholar 

  • Piazza PV, Deroche-Gamonent V, Rouge-Pont F, Le Moal M (2000) Vertical shifts in self-administration dose-response functions predict a drug-vulnerable phenotype predisposed to addiction. J Neurosci 20:4226–4232

    CAS  PubMed  Google Scholar 

  • Ronai Z, Szekely A, Nemoda Z, Lakatos K, Gervai J, Staub M, Sasvari-Szekely M (2001) Association between novelty seeking and the-521 C/T polymorphism in the promoter region of the DRD4 gene. Mol Psychiatry 6:35–38

    Article  CAS  PubMed  Google Scholar 

  • Rossetti ZL, Carboni S (1995) Ethanol withdrawal is associated with increased extracellular glutamate in the rat striatum. Eur J Pharmacol 283:177–183

    Article  CAS  PubMed  Google Scholar 

  • Sabeti J, Gerhardt GA, Zahniser NR (2002) Acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats. J Pharmacol Exp Ther 302:1201–1211

    Article  CAS  PubMed  Google Scholar 

  • Schepis TS, Desai RA, Smith AE, Cavallo DA, Liss TB, McFetridge A, Potenza MN, Krishnan-Sarin S (2008) Impulsive sensation seeking, parental history of alcohol problems, and current alcohol and tobacco use in adolescents. J Addict Med 2:185–193

    Article  PubMed  PubMed Central  Google Scholar 

  • Schneider Jr R, Ottoni GL, de Carvalho HW, Elisabetsky E, Lara DR (2015) Temperament and character traits associated with the use of alcohol, cannabis, cocaine, benzodiazepines, and hallucinogens: evidence from a large Brazilian web survey. Rev Bras Psiquiatr 37:31–39

  • See RE, Fuchs RA, Ledford CC, McLaughlin J (2003) Drug addiction, relapse, and the amygdala. Ann N Y Acad Sci 985:294–307

    Article  CAS  PubMed  Google Scholar 

  • Spear LP (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24:417–463

    Article  CAS  PubMed  Google Scholar 

  • Stautz K, Cooper A (2013) Impulsivity-related personality traits and adolescent alcohol use: a meta-analytic review. Clin Psychol Rev 33:574–592

    Article  PubMed  Google Scholar 

  • Stead JD, Clinton S, Neal C, Schneider J, Jama A, Miller S, Vazquez DM, Watson SJ, Akil H (2006) Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors. Behav Genet 36:697–712

    Article  PubMed  Google Scholar 

  • Sutker PB, Archer RP, Allain AN (1978) Drug abuse patterns, personality characteristics, and relationships with sex, race, and sensation seeking. J Consult Clin Psychol 46:1374–1378

    Article  CAS  PubMed  Google Scholar 

  • Suto N, Austin JD, Vezina P (2001) Locomotor response to novelty predicts a rat's propensity to self-administer nicotine. Psychopharmacology 158:175–180

    Article  CAS  PubMed  Google Scholar 

  • Thanos PK, Roushdy K, Sarwar Z, Rice O, Ashby Jr CR, Grandy DK (2015) The effect of dopamine D4 receptor density on novelty seeking, activity, social interaction, and alcohol binge drinking in adult mice. Synapse 69:356–364

  • Toda S (2012) [The role of the striatum in addiction]. brain and nerve =. Shinkei Kenkyu no Shinpo 64:911–917

    CAS  PubMed  Google Scholar 

  • Tournier BB, Steimer T, Millet P, Moulin-Sallanon M, Vallet P, Ibanez V, Ginovart N (2013) Innately low D2 receptor availability is associated with high novelty-seeking and enhanced behavioural sensitization to amphetamine. Int J Neuropsychopharmacol 16:1819–1834

    Article  CAS  PubMed  Google Scholar 

  • Vanhille N, Belin-Rauscent A, Mar AC, Ducret E, Belin D (2015) High locomotor reactivity to novelty is associated with an increased propensity to choose saccharin over cocaine: new insights into the vulnerability to addiction. Neuropsychopharmacology 40:577–589

    Article  CAS  PubMed  Google Scholar 

  • Walters GD (2002) The heritability of alcohol abuse and dependence: a meta-analysis of behavior genetic research. Am J Drug Alcohol Abuse 28:557–584

    Article  PubMed  Google Scholar 

  • Wang Y, Liu Y, Yang LZ, Gu F, Li XM, Zha RJ, Wei ZD, Pei YK, Zhang P, Zhou YF, Zhang XC (2015) Novelty seeking is related to individual risk preference and brain activation associated with risk prediction during decision making. Sci Rep-UK 5

  • Welker WI (1957) Free and forced exploration of a novel situation by rats. Psychol. Rep 3:95–108

  • Weyandt LL (2005) The Physiological Bases of Cognitive and Behavioral Disorders: Routledge.

  • Zheng X, Ke X, Tan B, Luo X, Xu W, Yang X, Sui N (2003) Susceptibility to morphine place conditioning: relationship with stress-induced locomotion and novelty-seeking behavior in juvenile and adult rats. Pharmacol Biochem Behav 75:929–935

    Article  CAS  PubMed  Google Scholar 

  • Zhu J, Apparsundaram S, Bardo MT, Dwoskin LP (2005) Environmental enrichment decreases cell surface expression of the dopamine transporter in rat medial prefrontal cortex. J Neurochem 93:1434–1443

    Article  CAS  PubMed  Google Scholar 

  • Zuckerman M (2007) The sensation seeking scale V (SSS-V): still reliable and valid. Personal Individ Differ 43:1303–1305

    Article  Google Scholar 

  • Zuckerman M, Cloninger CR (1996) Relationships between Cloninger's, Zuckerman's, and Eysenck's dimensions of personality. Personality and Individual Differences 21:283–285

  • Zuckerman M, Neeb M (1979) Sensation seeking and psychopathology. Psychiatry Res 1:255–264

    Article  CAS  PubMed  Google Scholar 

  • Zuckerman M, Kuhlman DM, Joireman J, Teta P, Kraft M (1993) A comparison of 3 structural models for personality - the big 3, the big 5, and the alternative 5. J Pers Soc Psychol 65:757–768

    Article  Google Scholar 

Download references

Acknowledgments

This work was supported, in part, by US National Institutes of Health grants DA-012844 and DA-026356.

Author information

Authors and Affiliations

  1. Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, 450 Ray C Hunt Drive, Suite G-170, Charlottesville, VA, 22903, USA

    Taylor Wingo, Tanseli Nesil, Jung-Seok Choi & Ming D. Li

  2. Department of Psychiatry, SMG-SNU Boramae Medical Center and Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, Republic of Korea

    Jung-Seok Choi

Authors
  1. Taylor Wingo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tanseli Nesil
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jung-Seok Choi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ming D. Li
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ming D. Li.

Ethics declarations

Conflict of Interest

The authors claim no conflict interest regarding this report.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wingo, T., Nesil, T., Choi, JS. et al. Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules. J Neuroimmune Pharmacol 11, 456–470 (2016). https://doi.org/10.1007/s11481-015-9636-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11481-015-9636-7

Keywords

Search

Navigation