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An efficient synthesis of substituted benzene-1,2-dicarboxaldehydes

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Abstract

Substituted-benzene-1,2-dicarbaldehydes were synthesized by the reaction of substituted-1,2-bis(dibromomethyl) benzenes with fuming sulfuric acid, followed by hydrolysis. The yields were significantly improved by introducing solid sodium bicarbonate into the reaction mixture before hydrolysis and workup.

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Authors and Affiliations

  1. Advanced Sterilization Products, Johnson & Johnson, 33 Technology Drive, Irvine, CA, 92618, USA

    Zhu Peter C., Wang Der-Haw & Lu Kaitao

  2. Pharmaceutical Research and Development La Jolla, Johnson & Johnson, 3210 Merryfield Row, San Diego, CA, 92121, USA

    Mani Neelakandha

Authors
  1. Zhu Peter C.
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  2. Wang Der-Haw
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  3. Lu Kaitao
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  4. Mani Neelakandha
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Correspondence to Zhu Peter C..

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Zhu, P.C., Wang, DH., Lu, K. et al. An efficient synthesis of substituted benzene-1,2-dicarboxaldehydes. SCI CHINA SER B 50, 249–252 (2007). https://doi.org/10.1007/s11426-007-0031-y

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  • DOI: https://doi.org/10.1007/s11426-007-0031-y

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