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Technologies to Enhance Spinal Fusion: Bench to Bedside

  • Current Concepts in Spinal Fusion/Commentary
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References

  1. Bae HW, Zhao L, Kanim LE, Wong P, Delamarter RB, Dawson EG. Intervariability and intravariability of bone morphogenetic proteins in commercially available demineralized bone matrix products. Spine. 2006;31(12):1299–1306.

    Article  Google Scholar 

  2. Boden SD, Schimandle JH, Hutton WC. An experimental lumbar intertransverse process spinal fusion model. Radiographic, histologic, and biomechanical healing characteristics. Spine. 1995;20(4):412–420.

    Article  CAS  Google Scholar 

  3. Carragee EJ, Hurwitz EL, Weiner BK. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J. 2011;11(6):471–491.

    Article  Google Scholar 

  4. Chang KY, McClendon M, Driscoll JA, et al. Friday, September 28, 2018 4:05–5:05 PM abstracts: basic science of spinal fusion: 235. Peptide amphiphile nanoscaffolds potentiates the delivery of rh-BMP2 in a rabbit spine fusion model. Spine J. 2018;18(8):S116–S117.

    Article  Google Scholar 

  5. Deyo RA, Ching A, Matsen L, et al. Use of bone morphogenetic proteins in spinal fusion surgery for older adults with lumbar stenosis: trends, complications, repeat surgery, and charges. Spine. 2012;37(3):222–230.

    Article  Google Scholar 

  6. Duda GN, Grainger DW, Frisk ML, et al. Changing the mindset in life sciences toward translation: a consensus. Sci Transl Med. 2014;6(264):264cm212.

    Article  Google Scholar 

  7. Edelman ER, LaMarco K. William Heberden and reverse translation. Sci Transl Med. 2015;7(287):287fs220.

    Article  Google Scholar 

  8. El Bialy I, Jiskoot W, Reza Nejadnik M. Formulation, delivery and stability of bone morphogenetic proteins for effective bone regeneration. Pharm Res. 2017;34(6):1152–1170.

    Article  Google Scholar 

  9. Fu R, Selph S, McDonagh M, et al. Effectiveness and harms of recombinant human bone morphogenetic protein-2 in spine fusion: a systematic review and meta-analysis. Ann Intern Med. 2013;158(12):890–902.

    Article  Google Scholar 

  10. Geiger M, Li RH, Friess W. Collagen sponges for bone regeneration with rhBMP-2. Adv Drug Deliv Rev. 2003;55(12):1613–1629.

    Article  CAS  Google Scholar 

  11. Hartgerink JD, Beniash E, Stupp SI. Self-assembly and mineralization of peptide-amphiphile nanofibers. Science. 2001;294(5547):1684–1688.

    Article  CAS  Google Scholar 

  12. Hobin JA, Deschamps AM, Bockman R, et al. Engaging basic scientists in translational research: identifying opportunities, overcoming obstacles. J Transl Med. 2012;10:72.

    Article  Google Scholar 

  13. Hsu WK, Nickoli MS, Wang JC, et al. Improving the clinical evidence of bone graft substitute technology in lumbar spine surgery. Global Spine J. 2012;2(4):239–248.

    Article  Google Scholar 

  14. Hsu EL, Ghodasra JH, Ashtekar A, et al. A comparative evaluation of factors influencing osteoinductivity among scaffolds designed for bone regeneration. Tissue Eng Part A. 2013;19(15–16):1764–1772.

    Article  CAS  Google Scholar 

  15. James AW, LaChaud G, Shen J, et al. A review of the clinical side effects of bone morphogenetic protein-2. Tissue Eng Part B Rev. 2016;22(4):284–297.

    Article  CAS  Google Scholar 

  16. Kissling S, Seidenstuecker M, Pilz IH, Suedkamp NP, Mayr HO, Bernstein A. Sustained release of rhBMP-2 from microporous tricalciumphosphate using hydrogels as a carrier. BMC Biotechnol. 2016;16(1):44.

    Article  Google Scholar 

  17. Kurpinski K, Johnson T, Kumar S, Desai T, Li S. Mastering translational medicine: interdisciplinary education for a new generation. Sci Transl Med. 2014;6(218):218fs212.

    Article  Google Scholar 

  18. Lee SS, Hsu EL, Mendoza M, et al. Gel scaffolds of BMP-2-binding peptide amphiphile nanofibers for spinal arthrodesis. Adv Healthc Mater. 2015;4(1):131–141.

    Article  CAS  Google Scholar 

  19. Lee SS, Fyrner T, Chen F, et al. Sulfated glycopeptide nanostructures for multipotent protein activation. Nat Nanotechnol. 2017;12(8):821–829.

    Article  CAS  Google Scholar 

  20. Li RH, Wozney JM. Delivering on the promise of bone morphogenetic proteins. Trends Biotechnol. 2001;19(7):255–265.

    Article  CAS  Google Scholar 

  21. Li H, Johnson NR, Usas A, et al. Sustained release of bone morphogenetic protein 2 via coacervate improves the osteogenic potential of muscle-derived stem cells. Stem Cells Transl Med. 2013;2(9):667–677.

    Article  CAS  Google Scholar 

  22. Lian TY, Lim KK. The legacy of William Heberden the Elder (1710–1801). Rheumatology. 2004;43(5):664–665.

    Article  CAS  Google Scholar 

  23. Liu W-C, Robu IS, Patel R, Leu MC, Velez M, Gabriel Chu T-M. The effects of 3D bioactive glass scaffolds and BMP-2 on bone formation in rat femoral critical size defects and adjacent bones. Biomed Mater. 2014;9(4):045013.

    Article  Google Scholar 

  24. Lobo M, Ibanez B. Take a deep (nitric oxide) breath and follow the reverse translational research pathway. Eur Heart J. 2018;39(29):2726–2729.

    Article  Google Scholar 

  25. Mapara M, Thomas BS, Bhat KM. Rabbit as an animal model for experimental research. Dent Res J (Isfahan). 2012;9(1):111–118.

    Article  Google Scholar 

  26. Mata A, Geng Y, Henrikson KJ, et al. Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix. Biomaterials.. 2010;31(23):6004–6012.

    Article  CAS  Google Scholar 

  27. Schroeder GD, Hsu WK, Kepler CK, et al. Use of recombinant human bone morphogenetic protein-2 in the treatment of degenerative spondylolisthesis. Spine. 2016;41(5):445–449.

    Article  Google Scholar 

  28. Simmonds MC, Brown JVE, Heirs MK, et al. Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data. Ann Intern Med. 2013;158(12):877–889.

    Article  Google Scholar 

  29. Urist MR. Bone: formation by autoinduction. 1965. Clin Orthop Relat Res. 2002(395):4–10.

    Google Scholar 

  30. Wancket LM. Animal models for evaluation of bone implants and devices: comparative bone structure and common model uses. Vet Pathol. 2015;52(5):842–850.

    Article  CAS  Google Scholar 

  31. Xie G, Sun J, Zhong G, Liu C, Wei J. Hydroxyapatite nanoparticles as a controlled-release carrier of BMP-2: absorption and release kinetics in vitro. J Mater Sci Mater Med. 2010;21(6):1875–1880.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Northwestern University, 676 N. Saint Clair St., Suite 1350, Chicago, IL, 60611, USA

    Allison C. Greene MPH & Wellington K. Hsu MD

  2. Simpson Querrey Institute, Northwestern University, 303 E. Superior St., Suite 11-131, Chicago, IL, 60611, USA

    Allison C. Greene MPH & Wellington K. Hsu MD

Authors
  1. Allison C. Greene MPH
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  2. Wellington K. Hsu MD
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Correspondence to Allison C. Greene MPH.

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Conflict of Interest

Allison C. Greene, MPH, reports no conflicts of interest. Wellington K. Hsu, MD, reports personal fees as a consultant from Medtronic, Stryker, Allosource, and Asahi and as a member of the advisory board for Bioventus, Mirus, Wright Medical, Lumbar Spine Research Society, Cervical Spine Research Society, and the National Football League, and has received institutional/research support from Medtronic, Baxter, and Pioneer Surgical. He receives royalties from Stryker.

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Greene, A.C., Hsu, W.K. Technologies to Enhance Spinal Fusion: Bench to Bedside. HSS Jrnl 16, 108–112 (2020). https://doi.org/10.1007/s11420-019-09733-8

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