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Anti-neutrophil Cytoplasmic Antibody (c-ANCA) Positive Recurrent Eosinophilic Fasciitis Responsive to Cyclophosphamide

A Clinical Pathology Conference Held by the Division of Rheumatology at Hospital for Special Surgery

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Abbreviations

ANA:

Antinuclear antibodies

c-ANCA:

Cytoplasmic antineutrophil cytoplasmic antibody

CRP:

C-reactive protein

CS:

Corticosteroids

CT:

Computed tomography

CYC:

Cyclophosphamide

EF:

Eosinophilic fasciitis

EMS:

Eosinophilia-myalgia syndrome

HES:

Idiopathic hypereosinophilic syndrome

HIV:

Human immunodeficiency virus

IgM, IgG, IgA:

Immunoglobulin M, G, A

IL:

Interleukin

IV:

Intravenous

IVIG:

Intravenous immunoglobulins

MAC:

Membrane attack complex

MPO:

Myeloperoxidase antibody

MRA:

Magnetic resonance angiography

MRI:

Magnetic resonance imaging

p-ANCA:

Perinuclear antineutrophil cytoplasmic antibody

PDGFRA:

Platelet-derived growth factor receptor alpha

PR3:

Proteinase 3 antibodies

PUVA:

Psoralen plus ultraviolet A

ROM:

Range of motion

sIgMD:

Selective Immunoglobulin M Deficiency

TGF β:

Transforming growth factor-beta

References

  1. Shulman LE (1974) Diffuse fasciitis with hypergammaglobulinemia and eosinophilia: a new syndrome? J Rheumatol(Suppl 1):82

  2. Shulman LE (1970) Diffuse fasciitis with eosinophilia: a new syndrome? Trans Assoc Am Physicians 88:70–86

    Google Scholar 

  3. Choquet-Kastylevsky G, Kanitakis J, Dumas V, et al. (2001) Eosinophilic fasciitis and simvastatin. Arch Intern Med 161:1456–1457

    Article  PubMed  CAS  Google Scholar 

  4. DeGiovanni C, Chard M, Woollons A (2006) Eosinophilic fasciitis secondary to treatment with atorvastatin. Clin Exp Dermatol 31:131–132

    Article  PubMed  CAS  Google Scholar 

  5. Buchanan RR, Gordon DA, Muckle TJ, et al. (1980) The eosinophilic fasciitis syndrome after phenytoin (dilantin) therapy. J Rheumatol 7:733–736

    PubMed  CAS  Google Scholar 

  6. Hashimoto Y, Takahashi H, Matsuo S, et al. (1996) Polymerase chain reaction of Borrelia burgdorferi flagellin gene in Shulman syndrome. Dermatology 192:136–139

    Article  PubMed  CAS  Google Scholar 

  7. Granter SR, Barnhill RL, Duray PH (1996) Borrelial fasciitis: diffuse fasciitis and peripheral eosinophilia associated with Borrelia infection. Am J Dermatopathol 18:465–473

    Article  PubMed  CAS  Google Scholar 

  8. Hayashi N, Igarashi A, Matsuyama T, et al. (2000) Eosinophilic fasciitis following exposure to trichloroethylene: successful treatment with cyclosporine. Br J Dermatol 142:830–832

    Article  PubMed  CAS  Google Scholar 

  9. Liou CH, Huang GS, Taylor JA, et al. (2003) Eosinophilic fasciitis in a military recruit: MRI evaluation with clinical correlation. Skeletal Radiol 32:52–57

    Article  PubMed  Google Scholar 

  10. Littlejohn GO, Keystone EC (1980) Eosinophilic fasciitis and aplastic anemia. J Rheumatol 7:730–732

    PubMed  CAS  Google Scholar 

  11. Khanna D, Verity A, Grossman JM (2002) Eosinophilic fasciitis with multiple myeloma: a new hematological association. Ann Rheum Dis 61:1111–1112

    Article  PubMed  CAS  Google Scholar 

  12. Michaels RM (1982) Eosinophilic fasciitis complicated by Hodgkin’s disease. J Rheumatol 9:473–476

    PubMed  CAS  Google Scholar 

  13. Ohno M, Nagaoka S, Onari K, et al. (2001) Remitting fasciitis without eosinophilia: a new disease entity? A case report. Rheumatology (Oxford) 40:1428–1430

    Article  CAS  Google Scholar 

  14. Antic M, Lautenschlager S, Itin PH (2006) Eosinophilic fasciitis 30 years after—What do we really know? Report of 11 patients and review of the literature. Dermatology 213:93–101

    Article  PubMed  Google Scholar 

  15. Kazatchkine MD, Bayry J, Lacroix-Desmazes S, et al. (2004) Mechanisms of action of intravenous immunoglobulin in autoimmune and inflammatory diseases. In: MC Dalakas, PJ Späth (ed) Intravenous immunoglobulins in the third millennium. The Parthenon Publishing Group, New York, pp 106–107

    Google Scholar 

  16. Agnew KL, Blunt D, Francis ND, et al. (2005) Magnetic resonance imaging in eosinophilic fasciitis. Clin Exp Dermatol 30:435–436

    Article  PubMed  CAS  Google Scholar 

  17. Sugimoto T, Nitta N, Kashiwag A (2007) Usefulness of magnetic resonance imaging in eosinophilic fasciitis. Rheumatol Int 27:791–792

    Article  PubMed  Google Scholar 

  18. Gotlib J, Cools J, Malone JM III, et al. (2004) The FIP1L1- PDGFRα fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia, implications for diagnosis, classification, and management. Blood 103:2879–2891

    Article  PubMed  CAS  Google Scholar 

  19. Cools J, DeAngelo DJ, Gotlib J, et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med 348(13):1201–1214

  20. Grobner T (2006) Gadolinium: a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? Nephrol Dial Transplant 21:1104–1108

    Article  PubMed  CAS  Google Scholar 

  21. Galan A, Cowper SE, Bucala R (2006) Nephrogenic systemic fibrosis (nephrogenic fibrosing dermopathy). Curr Opin Rheumatol 18:614–617

    Article  PubMed  Google Scholar 

  22. Pouplin S, Daragon A, Le Loët X, et al. (1998) Treatment of eosinophilic fasciitis with methotrexate. J Rheumatol 25:606–607

    PubMed  CAS  Google Scholar 

  23. Jensen E, Hess B, Hunziker T, et al. (2000) Eosinophilic fasciitis (Shulman syndrome). Schweiz Med Wochenschr 130:156–160

    PubMed  CAS  Google Scholar 

  24. Bukiej A, Dropińsky J, Dyduch G, et al. (2005) Eosinophilic fasciitis successfully treated with cyclosporine, case report. Clin Rheumatol 24:634–636

    Article  PubMed  Google Scholar 

  25. Valencia IC, Chang A, Kirsner RS, et al. (1999) Eosinophilic fasciitis responsive to treatment with pulse steroids and cyclosporine. Int J Dermatol 38:369–372

    Article  Google Scholar 

  26. Schiener R, Behrens-Williams SC, Gottlöber P, et al. (2000) Eosinophilic fasciitis treated with psoralen-ultraviolet A bath photochemotherapy. Br J Dermatol 142:804–807

    Article  PubMed  CAS  Google Scholar 

  27. Solomon G, Barland P, Rifkin H (1982) Eosinophilic fasciitis responsive to cimetidine. Ann Intern Med 97:547–549

    PubMed  CAS  Google Scholar 

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Correspondence to Doruk Erkan MD.

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Haiduc, V.F., Erkan, D., Kirou, K. et al. Anti-neutrophil Cytoplasmic Antibody (c-ANCA) Positive Recurrent Eosinophilic Fasciitis Responsive to Cyclophosphamide. HSS Jrnl 4, 81–86 (2008). https://doi.org/10.1007/s11420-007-9067-y

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  • DOI: https://doi.org/10.1007/s11420-007-9067-y

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