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Cell death-inducing activities via Hsp inhibition of the sesquiterpenes isolated from Valeriana fauriei

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Abstract

Three new sesquiterpenes, valerianaterpenes I–III, and eight known compounds have been isolated from the methanol extract of the rhizomes and roots of Valeriana fauriei. The chemical structures of the three new sesquiterpenes were elucidated based on chemical and spectroscopic evidence. The absolute stereochemistry of valerianaterpene I was determined using X-ray crystallography. The cell death-inducing activity of isolated compounds alone or combination with Adriamycin (ADR) was observed by time-lapse cell imaging. Although the isolated compounds did not affect the number of mitotic entry cells and dead cells alone, kessyl glycol, kessyl glycol diacetate, and iso-teucladiol significantly increased the number of dead cells on ADR treated human cervical cancer cells. One of the mechanisms of cell death-inducing activity for the kessyl glycol acetate was suggested to be the inhibition of heat-shock protein 105 (Hsp105) expression level. This paper first deals with the naturally occurring compounds as Hsp105 inhibitor.

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Acknowledgements

This work was supported by JSPS KAKENHI Grant Numbers 20H03397 and 20J14567.

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Authors and Affiliations

  1. Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, 607-8412, Japan

    Takahiro Matsumoto, Takahiro Kitagawa, Daisuke Imahori, Hayato Yoshikawa, Masaya Okayama, Mayuka Kobayashi, Naoto Kojima, Masayuki Yamashita & Tetsushi Watanabe

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  1. Takahiro Matsumoto
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  2. Takahiro Kitagawa
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  3. Daisuke Imahori
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  4. Hayato Yoshikawa
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  9. Tetsushi Watanabe
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Correspondence to Takahiro Matsumoto or Tetsushi Watanabe.

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Matsumoto, T., Kitagawa, T., Imahori, D. et al. Cell death-inducing activities via Hsp inhibition of the sesquiterpenes isolated from Valeriana fauriei. J Nat Med 75, 942–948 (2021). https://doi.org/10.1007/s11418-021-01543-9

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  • DOI: https://doi.org/10.1007/s11418-021-01543-9

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