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Pregnane glycosides from the bark of Marsdenia cundurango and their cytotoxic activity

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Abstract

Seven new pregnane glycosides (1–7) and eight known compounds (8–15) were isolated from the bark of Marsdenia cundurango (Asclepiadaceae). The structures of 1–7 were determined by spectroscopic analysis, including two-dimension NMR spectroscopy, chemical transformations, and chromatographic analysis of the hydrolyzed products. The isolated compounds 1–15 were evaluated for their cytotoxic activity against HL-60 human leukemia cells, A549 human lung adenocarcinoma cells, and TIG-3 normal human lung cells, including apoptosis-inducing activity of a representative pregnane glycoside in HL-60 cells.

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Acknowledgements

This work was financially supported in part by the Japan Society for the Promotion of Sciences (JSPS) KAKENHI (Grant number 26860069).

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Authors and Affiliations

  1. Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan

    Satoru Tatsuno, Akihito Yokosuka, Fusako Hatsuma, Yuto Mashiko & Yoshihiro Mimaki

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  1. Satoru Tatsuno
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  2. Akihito Yokosuka
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  3. Fusako Hatsuma
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  4. Yuto Mashiko
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  5. Yoshihiro Mimaki
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Correspondence to Akihito Yokosuka.

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Tatsuno, S., Yokosuka, A., Hatsuma, F. et al. Pregnane glycosides from the bark of Marsdenia cundurango and their cytotoxic activity. J Nat Med 73, 93–103 (2019). https://doi.org/10.1007/s11418-018-1248-0

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  • DOI: https://doi.org/10.1007/s11418-018-1248-0

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