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Cytotoxicity of compounds from the fruits of Derris indica against cholangiocarcinoma and HepG2 cell lines

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Abstract

Two new compounds, derrivanone (1) and derrischalcone (2), were isolated from the crude hexane extract of the fruits of Derris indica. In addition, 14 known compounds were isolated from the fruits of this plant. Chalcones 2–4 showed strong cytotoxicity against cholangiocarcinoma cell line (M156) and human hepatoma HepG2 cells. In addition, flavanones 15 and 16 exhibited potent and high cytotoxic efficacy.

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Acknowledgments

We thank Khon Kaen University, Royal Golden Jubilee Scholarship (PHD/0020/2556) and The Center of Excellence for Innovation in Chemistry (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education for financial support. The National Research University Project of Thailand through the Advanced Functional Materials Cluster of Khon Kaen University is gratefully acknowledged.

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Authors and Affiliations

  1. Natural Products Research Unit, Department of Chemistry, Faculty of Science, Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, 40002, Thailand

    Phatharapoll Decharchoochart, Jittra Suthiwong & Chavi Yenjai

  2. Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand

    Papavee Samatiwat & Veerapol Kukongviriyapan

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  1. Phatharapoll Decharchoochart
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  2. Jittra Suthiwong
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Correspondence to Chavi Yenjai.

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Decharchoochart, P., Suthiwong, J., Samatiwat, P. et al. Cytotoxicity of compounds from the fruits of Derris indica against cholangiocarcinoma and HepG2 cell lines. J Nat Med 68, 730–736 (2014). https://doi.org/10.1007/s11418-014-0851-y

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  • DOI: https://doi.org/10.1007/s11418-014-0851-y

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