Skip to main content

Advertisement

Log in

Commentary: rapamycin for the aging skin

  • Letter to the Editor
  • Published:
GeroScience Aims and scope Submit manuscript

Abstract

A response is provided to a commentary on a recent study examining the impact of low-dose topical application of rapamycin on markers of aging in the skin. The barriers to clinical implementation of therapies targeting the fundamental aging process are discussed, and the topical study is placed in context with the broader effort to develop new therapeutics for age-related disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Bitto A, Lerner C, Torres C, Roell M, Malaguti M, Perez V, et al. Long-term IGF-I exposure decreases autophagy and cell viability. PLoS One. 2010;5:e12592.

    Article  Google Scholar 

  • Blagosklonny MV. Rapamycin for the aging skin. Aging (Albany NY). 2019;11:12822–6.

    Article  Google Scholar 

  • Campisi J, Kapahi P, Lithgow GJ, Melov S, Newman JC, Verdin E. From discoveries in ageing research to therapeutics for healthy ageing. Nature. 2019;571:183–92.

    Article  CAS  Google Scholar 

  • Chiao YA, Rabinovitch PS. The aging heart. Cold Spring Harb Perspect Med. 2015;5:a025148.

    Article  Google Scholar 

  • Chung CL, Lawrence I, Hoffman M, Elgindi D, Nadhan K, Potnis M, et al. Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial. Geroscience. 2019;41:861–9.

    Article  CAS  Google Scholar 

  • Justice JN, Niedernhofer L, Robbins PD, Aroda VR, Espeland MA, Kritchevsky SB, et al. Development of clinical trials to extend healthy lifespan. Cardiovasc Endocrinol Metab. 2018;7:80–3.

    Article  Google Scholar 

  • Kaeberlein M, Galvan V. Rapamycin and Alzheimer's disease: time for a clinical trial? Sci Transl Med. 2019;11.

  • Kirkland JL, Tchkonia T. Cellular senescence: a translational perspective. EBioMedicine. 2017;21:21–8.

    Article  Google Scholar 

  • Koenig MK, Bell CS, Hebert AA, Roberson J, Samuels JA, Slopis JM, et al. Efficacy and safety of topical Rapamycin in patients with facial angiofibromas secondary to tuberous sclerosis complex: the TREATMENT randomized clinical trial. JAMA Dermatol. 2018;154:773–80.

    Article  Google Scholar 

  • Lawrence J, Nho R. The role of the mammalian target of Rapamycin (mTOR) in pulmonary fibrosis. Int J Mol Sci. 2018;19.

  • Lerner C, Bitto A, Pulliam D, Nacarelli T, Konigsberg M, Van Remmen H, et al. Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts. Aging Cell. 2013.

  • Liao CY, Rikke BA, Johnson TE, Diaz V, Nelson JF. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell. 2010;9:92–5.

    Article  CAS  Google Scholar 

  • Lichterfeld-Kottner A, El Genedy M, Lahmann N, Blume-Peytavi U, Buscher A, Kottner J. Maintaining skin integrity in the aged: a systematic review. Int J Nurs Stud. 2019;103:103509.

    Article  Google Scholar 

  • Seymore S.. Patenting new uses for old inventions. Vanderbilt Law Review Forthcoming. 2019

  • Urfer SR, Kaeberlein TL, Mailheau S, Bergman PJ, Creevy KE, Promislow DEL, et al. A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs. Geroscience. 2017;39:117–27.

    Article  CAS  Google Scholar 

  • Verges B, Cariou B. mTOR inhibitors and diabetes. Diabetes Res Clin Pract. 2015;110:101–8.

    Article  CAS  Google Scholar 

  • Wataya-Kaneda M, Ohno Y, Fujita Y, Yokozeki H, Niizeki H, Ogai M, et al. Sirolimus gel treatment vs placebo for facial angiofibromas in patients with tuberous sclerosis complex: a randomized clinical trial. JAMA Dermatol. 2018;154:781–8.

    Article  Google Scholar 

  • Wilfond BS, Porter KM, Creevy KE, Kaeberlein M, Promislow D. Research to promote longevity and health span in companion dogs: a pediatric perspective. Am J Bioeth. 2018;18:64–5.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Christian Sell.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sell, C. Commentary: rapamycin for the aging skin. GeroScience 42, 813–815 (2020). https://doi.org/10.1007/s11357-020-00184-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11357-020-00184-2

Navigation