Abstract
Moorena producens is a benthic filamentous cyanobacteria that has been widely documented for its toxicity. This cyanobacterium colonizes both temperate (37%) and tropical (63%) regions, making it a cosmopolitan cyanobacterium with a global distribution. M. producens grows across coral reefs in multiple locations but recurringly blooms in Queensland, Australia. Today, nuisance blooms of M. producens have resulted in major disruptions to recreational activities along coastal areas and are known to cause adverse effects on organism and human health upon contact or ingestion. Specifically, marine organisms such as the green turtle Chelonia mydas and hawksbill turtle Eretmochelys imbricata were fatally poisoned by M. producens after consumption of this cyanobacterium. Reports record a range of effects on human health, from pain and blistering or even death upon ingestion of contaminated seafood. Blooms of M. producens are triggered by influxes of nitrogen, phosphate and iron, from surrounding coastal runoffs or sewage effluents. Additions of these nutrients can result in an increase in growth rate by 4–16 times. Iron bioavailability also plays a crucial role in bloom formation. A total of 231 natural products from 66 groups were identified from M. producens, with the three dominant groups: malyngamides, microcolins and dolastatins. These bioactive secondary metabolites have displayed toxicities against a range of carcinoma cell lines and organisms such as brine shrimp Artemia salina and goldfish Carassius auratus. This review provides a thorough insight to the distribution, ecophysiology and toxicity of M. producens, with reports on bloom events and implications on organism and human health.
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Adams J (1907) The seaweeds of the Antrim coast. Sci Papers Ulster Fish Biol Assoc 1:29–37
Afonso-Carrillo J (2014) Una Blidingia (Ulvophyceae), macroalga verde dominante en el salto de agua de Lomo Morín, Tenerife (islas Canarias). Vieraea Folia Scientarium Biologicarum Canariensum 45:285–302
Afonso-Carrillo J, Gallardo T, Bárbara I, Bermejo R, Altamirano M, Gómez Garreta A, Martí B, Rull Lluch J, Ballesteros E, De la Rosa J (2016) Nueva lista crítica de las algas bentónicas marinas de España. Algas, Boletin Informativo de la Siciedad Española de Ficologia 51:7–52
Aggarwal A, Sharma I, Tripathi BN, Munjal AK, Baunthiyal M, Sharma V (2012) Metal toxicity and photosynthesis. Overviews Recent Progress Future Perspect, Photosynthesis, pp 229–236
Agha R, Cirés S, Wörmer L, Domínguez JA, Quesada A (2012) Multi-scale strategies for the monitoring of freshwater cyanobacteria: reducing the sources of uncertainty. Water Res 46(9):3043–3053
Ahern KS, Ahern CR, Udy JW (2007) Nutrient additions generate prolific growth of Lyngbya majuscula (cyanobacteria) in field and bioassay experiments. Harmful Algae 6(1):134–151
Álvarez Cobelas M (1988) Catálogo de las algas continentales españolas. V. Cyanophyceae Schaffner 1909. Acta Botánica Malacitana 13:53–76
Aimi N, Odaka H, Sakai SI, Fujiki H, Suganuma M, Moore RE, Patterson GML (1990) Lyngbyatoxins B and C, two new irritants from Lyngbya majuscula. J Nat Prod 53(6):1593–1596
Ainslie RD, Moore RE, Patterson GM (1986) (S)-(−)-3, 4-dihydroxybutanoic acid γ-lactone from puerto rican Lyngbya majuscula. Phytochemistry 25(11):2654–2655
Albay ME, Akcaalan RE, Aykulu G, Tufekci H, Beattie KA, Codd GA (2003) Occurrence of toxic cyanobacteria before and after copper sulphate treatment in a water reservoir, Istanbul, Turkey. Archiv Fur Hydrobiologie-Supplement 148:67–78
Al-Shehri AM (2006) Factors affecting alkaline phosphatase activity of the marine cyanobacterium Lyngbya majuscula. J Biol Sci 6(5):931–935
Al-Shehri AM, Mohamed ZA (2007) Mass occurrence and toxicity of the cyanobacterium Lyngbya majuscula under phosphorus-limited conditions in the Red Sea. Ecohydrol Hydrobiol 7(1):51–57
Almaliti J, Malloy KL, Glukhov E, Spadafora C, Gutiérrez M, Gerwick WH (2017) Dudawalamides A-D, antiparasitic cyclic depsipeptides from the marine cyanobacterium Moorea producens. J Nat Prod 80(6):1827–1836
Arthur K, Limpus C, Balazs G, Capper A, Udy J, Shaw G, Keuper-Bennett U, Bennett P (2008) The exposure of green turtles (Chelonia mydas) to tumour promoting compounds produced by the cyanobacterium Lyngbya majuscula and their potential role in the aetiology of fibropapillomatosis. Harmful Algae 7(1):114–125
Arthur KE, Limpus CJ, Roelfsema CM, Udy JW, Shaw GR (2006) A bloom of Lyngbya majuscula in Shoalwater Bay, Queensland, Australia: an important feeding ground for the green turtle (Chelonia mydas). Harmful Algae 5(3):251–265
Balunas MJ, Linington RG, Tidgewell K, Fenner AM, Ureña LD, Togna GD, Kyle DE, Gerwick WH (2010) Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity. J Nat Prod 73(1):60–66
Banner AH (1959) A dermatitis-producing alga in Hawaii. Preliminary report. Hawaii Med J 19(1):35–36
Bell PR, Elmetri I (2007) Some chemical factors regulating the growth of Lyngbya majuscula in Moreton Bay, Australia: importance of sewage discharges. Hydrobiologia 592(1):359–371
Berman FW, Gerwick WH, Murray TF (1999) Antillatoxin and kalkitoxin, ichthyotoxins from the tropical cyanobacterium Lyngbya majuscula, induce distinct temporal patterns of NMDA receptor-mediated neurotoxicity. Toxicon 37(11):1645–1648
Beutler JA, Alvarado AB, Schaufelberger DE, Andrews P, McCloud TG (1990) Dereplication of phorbol bioactives: Lyngbya majuscula and Croton cuneatus. J Nat Prod 53(4):867–874
Bhakta S, Das SK, Adhikary SP (2016) Algal diversity in hot springs of Odisha. Nelumbo 58:157–173
Bonnard I, Rolland M, Francisco C, Banaigs B (1997) Total structure and biological properties of laxaphycins A and B, cyclic lipopeptides from the marine cyanobacterium Lyngbya majuscula. Lett Pept Sci 4(4):289–292
Bösch NM, Borsa M, Greczmiel U, Morinaka BI, Gugger M, Oxenius A, Vagstad AL, Piel J (2020) Landornamides: antiviral ornithine-containing ribosomal peptides discovered through genome mining. Angew Chem 132(29):11861–11866
Bostock P, Holland A, Herbarium Q (2014) Introduction to the Census of the Queensland Flora 2014. Department of Science, Information Technology, Innovation and the Arts
Boudreau PD, Monroe EA, Mehrotra S, Desfor S, Korobeynikov A, Sherman DH, Murray TF, Gerwick L, Dorrestein PC, Gerwick WH (2015) Expanding the described metabolome of the marine cyanobacterium Moorea producens JHB through orthogonal natural products workflows. PLoS ONE 10(7):e0133297
Broady PA, Merican F (2012) Phylum Cyanobacteria: blue-green bacteria, blue-green algae: Kingdoms Bacteria, Protozoa, Chromista, Plantae, Fungi. New Zealand Inventory Biodivers 3:50–69
Brocke HJ, Piltz B, Herz N, Abed RM, Palinska KA, John U, Den Haan J, de Beer D, Nugues MM (2018) Nitrogen fixation and diversity of benthic cyanobacterial mats on coral reefs in Curaçao. Coral Reefs 37(3):861–874
Brook AJ, John DM, Whitton BA (Eds) (2011) The freshwater algal flora of the British Isles: an identification guide to freshwater and terrestrial algae. (pp. 20-130) Cambridge University Press
Buggeln RG, Tsuda RT (1969) A record of benthic marine algae from Johnston Atoll. Atoll Res Bull 120:1-20
Bunyajetpong S, Yoshida WY, Sitachitta N, Kaya K (2006) Trungapeptins A− C, cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 69(11):1539–1542
Burford MA, Beardall J, Willis A, Orr PT, Magalhaes VF, Rangel LM, Azevedo SM, Neilan BA (2016) Understanding the winning strategies used by the bloom-forming cyanobacterium Cylindrospermopsis raciborskii. Harmful Algae 54:44–53
Capper A, Tibbetts IR, O’Neil JM, Shaw GR (2005) The fate of Lyngbya majuscula toxins in three potential consumers. J Chem Ecol 31(7):1595–1606
Capper A, Tibbetts IR, O’Neil JM, Shaw GR (2006) Dietary selectivity for the toxic cyanobacterium Lyngbya majuscula and resultant growth rates in two species of opisthobranch mollusc. J Exp Mar Biol Ecol 331(2):133–144
Cardellina JH II, Moore RE (1980) Malyngic acid, a new fatty acid from Lyngbya majuscula. Tetrahedron 36(8):993–996
Cardellina JH, Marner FJ, Moore RE (1979a) Seaweed dermatitis: structure of lyngbyatoxin A. Science 204(4389):193–195
Cardellina JH, Moore RE, Arnold EV, Clardy J (1979b) Structure and absolute configuration of malyngolide, an antibiotic from the marine blue-green alga Lyngbya majuscula Gomont. J Org Chem 44(23):4039–4042
Cardillo G, Orena M, Porzi G, Sandri S (1981) Synthesis of malyngolide, an antibiotic from the marine blue-green alga Lyngbya majuscula Gomont. J Org Chem 46(12):2439–2442
Cărăuş I (2017) Algae of Romania. A distributional checklist of actual algae. Version 2.4. Studii Cercercetare Biologie, Universitatea Bacău 7:1–1002
Carter DC, Moore RE, Mynderse JS, Niemczura WP, Todd JS (1984) Structure of majusculamide C, a cyclic depsipeptide from Lyngbya majuscula. J Org Chem 49(2):236–241
Celiz MD, Tso J, Aga DS (2009) Pharmaceutical metabolites in the environment: analytical challenges and ecological risks. Environ Toxicol Chem 28(12):2473–2484
Chapman VJ (1977) Marine algae of Norfolk Island and the Cook Islands. Bot Mar 20:161–165
Charpy L, Palinska KA, Abed RM, Langlade MJ, Golubic S (2012) Factors influencing microbial mat composition, distribution and dinitrogen fixation in three western Indian Ocean coral reefs. Eur J Phycol 47(1):51–66
Chaudhari GS, Nandan SN (2003) Preliminary survey on cyanophyceae potential from Akkalpada dam of Dhule, Maharashtra. Int J Res Biosci Agric Technol 4(2):34–35
Chlipala GE, Tri PH, Hung NV, Krunic A, Shim SH, Soejarto DD, Orjala J (2010) Nhatrangins A and B, aplysiatoxin-related metabolites from the marine cyanobacterium Lyngbya majuscula from Vietnam. J Nat Prod 73(4):784–787
Churro C, Azevedo J, Vasconcelos V, Silva A (2017) Detection of a Planktothrix agardhii bloom in Portuguese marine coastal waters. Toxins 9(12):391
Cires Rodríguez E, Cuesta Moliner C (2010) Checklist of benthic algae from the Asturias coast (North of Spain). Boletín de Ciencias de la Naturaleza 51:135–212
Cotton AD (1912) Clare Island Survey: marine algae. Proc R Ir Acad 31(part 15):1–178
Cremades J, Bárbara I, Calvo S, Dosil J, Rodríguez MDCL (2005) Checklist of the benthic marine and brackish Galician algae (NW Spain). Anales Del Jardín Botánico De Madrid 62(1):69–100
Curren E, Leong SCY (2019) Global phylogeography of toxic cyanobacteria Moorea producens reveals distinct genetic partitioning influenced by Proterozoic glacial cycles. Harmful Algae 86:10–19
Dalietos D, Marner FJ, Mynderse JS, Moore RE (1978) (−)-Trans-7 (S)-methoxytetradec-4-enoic acid and related amides from the marine cyanophyte Lyngbya majuscula. Phytochemistry 17(12):2091–2095
Davies-Coleman MT, Dzeha TM, Gray CA, Hess S, Pannell LK, Hendricks DT, Arendse CE (2003) Isolation of Homodolastatin 16, a new cyclic depsipeptide from a Kenyan collection of Lyngbya majuscula. J Nat Prod 66(5):712–715
Dawson EY (1954) Marine plants in the vicinity of the Institute Oceanography of Nha Trang. Pac Sci 8(4):373–471
Dawson EY (1957) An annotated list of marine algae from Eniwetok Atoll Marshall Islands. Pac Sci 11(1):92–132
Dawson EY (1959) Changes in Palmyra Atoll and its vegetation through the activities of man, 1913–1958. Pac Naturalist 1:1
Day SA, Wickham RP, Entwisle TJ, Tyler PA (1995) Bibliographic check-list of non-marine algae in Australia. Flora of Australia Supplementary Series 4: [i]-vii:1–276
De la Rosa Álamos J (2016) Catálogo florístico de las cyanoprokariotas bentónicas del litoral de Andalucía. Checklist of the benthic cyanoprokariotas in Andalusian coast. Acta Bot Malacitana 41:5–18
de Maagd PGJ, Hendriks AJ, Seinen W, Sijm DT (1999) pH-dependent hydrophobicity of the cyanobacteria toxin microcystin-LR. Water Res 33(3):677–680
Degener O, Gillaspy E (1955) Canton Island, South Pacific. Atoll Res Bull 41:1–51
Dennison WC, O'Neil JM, Duffy EJ (1999) Blooms of the cyanobacterium Lyngbya majuscula in coastal waters of Queensland, Australia. Bull Einstitut 501–506
Dixon PS (1961) List of marine algae collected in the Channel Islands during the joint meeting of the British Phycological Society and the Société Phycologique de France September 1960. British Phycol Bull 2:71–80
Dobretsov S, Teplitski M, Alagely A, Gunasekera SP, Paul VJ (2010) Malyngolide from the cyanobacterium Lyngbya majuscula interferes with quorum sensing circuitry. Environ Microbiol Rep 2(6):739–744
Doi T, Numajiri Y, Munakata A, Takahashi T (2006) Total synthesis of apratoxin A. Org Lett 8(3):531–534
Dunne RP, Brown BE (1996) Penetration of solar UVB radiation in shallow tropical waters and its potential biological effects on coral reefs; results from the central Indian Ocean and Andaman Sea. Mar Ecol Prog Ser 144:109–118
Edwards DJ, Marquez BL, Nogle LM, McPhail K, Goeger DE, Roberts MA, Gerwick WH (2004) Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. Chem Biol 11(6):817–833
El-Kassas HY, Okbah MAEA (2017) Phytotoxic effects of seaweed mediated copper nanoparticles against the harmful alga: Lyngbya majuscula. J Genet Eng Biotechnol 15(1):41–48
Elmetri I, Bell PR (2004) Effects of phosphorus on the growth and nitrogen fixation rates of Lyngbya majuscula: implications for management in Moreton Bay, Queensland. Mar Ecol Prog Ser 281:27–35
Engene N, Rottacker EC, Kaštovský J, Byrum T, Choi H, Ellisman MH, Komárek J, Gerwick WH (2012) Moorea producens gen. nov., sp. nov. and Moorena bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites. Int J Syst Evol Microbiol 62(Pt 5):1171
Estrella SM, Storey AW, Pearson G, Piersma T (2011) Potential effects of Lyngbya majuscula blooms on benthic invertebrate diversity and shorebird foraging ecology at Roebuck Bay, Western Australia: preliminary results. J R Soc West Aust 94(2):171
Feldmann J (1954) Inventaire de la flore marine de Roscoff. Algues, champignons, lichens et spermatophytes. Travaux Station Biologique Roscoff Supplement 6:1–152
Finni T, Kononen K, Olsonen R, Wallström K (2001) The history of cyanobacterial blooms in the Baltic Sea. AMBIO: J Human Environ 30(4):172–178
Ganesan EK (1989) A catalog of benthic marine algae and seagrasses of Venezuela. Fondo Editorial Conicit pp. 237
Ganesan M, Selvaraj K, Chithra K, Sirajudeen S (2015) Epiphytism differences in Gelidiella acerosa cultivated with floating rafts and concrete blocks. J Appl Phycol 27(1):399–412
Garay JMG, Souto AS, Díez I, de Castro AS, Pascual CC (2004) Check-list of the Basque coast benthic algae (North of Spain). Anales Del Jardín Botánico De Madrid 61(2):155–180
García R, Johnstone RW (2006) Effects of Lyngbya majuscula (Cyanophycea) blooms on sediment nutrients and meiofaunal assemblages in seagrass beds in Moreton Bay Australia. Mar Freshw Res 57(2):155–165
Gerwick WH, Proteau PJ, Nagle DG, Hamel E, Blokhin A, Slate DL (1994) Structure of curacin A, a novel antimitotic, antiproliferative and brine shrimp toxic natural product from the marine cyanobacterium Lyngbya majuscula. J Org Chem 59(6):1243–1245
Gerwick WH, Reyes S, Alvarado B (1987) Two malyngamides from the Caribbean cyanobacterium Lyngbya majuscula. Phytochemistry 26(6):1701–1704
Ghosh S, Keshri JP (2011) Some Cyanophycean algae from the coastal regions of Visakhapatnam, India. J Indian Bot Soc 90(1–2):165–167
Gkelis S, Ourailidis I, Panou M, Pappas N (2016) Cyanobacteria of Greece: an annotated checklist. Biodivers Data J 4:e10084
Graber MA, Gerwick WH (1998) Kalkipyrone, a toxic γ-pyrone from an assemblage of the marine cyanobacteria Lyngbya majuscula and Tolypothrix sp. J Nat Prod 61(5):677–680
Grauer FH, Arnold HL (1961) Seaweed dermatitis: first report of a dermatitis-producing marine alga. Arch Dermatol 84(5):720–732
Gross ED, Martin DF (1996) Iron dependence of Lyngbya majuscula. J Aquat Plant Manag 34:17–20
Gross H, McPhail KL, Goeger DE, Valeriote FA, Gerwick WH (2010) Two cytotoxic stereoisomers of malyngamide C, 8-epi-malyngamide C and 8-O-acetyl-8-epi-malyngamide C, from the marine cyanobacterium Lyngbya majuscula. Phytochemistry 71(14–15):1729–1735
Gunasekera SP, Owle CS, Montaser R, Luesch H, Paul VJ (2011) Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon Guam. J Nat Prod 74(4):871–876
Gupta RK, Das SK (2019) Algae of Karnataka - a checklist. Karnataka: Karnataka Biodiversity Board 1:1–185
Gutiérrez M, Andrianasolo EH, Shin WK, Goeger DE, Yokochi A, Schemies J, Jung M, France D, Cornell-Kennon S, Lee E, Gerwick WH (2009) Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula. J Org Chem 74(15):5267–5275
Gutiérrez M, Tidgewell K, Capson TL, Engene N, Almanza A, Schemies J, Jung M, Gerwick WH (2010) Malyngolide dimer, a bioactive symmetric cyclodepside from the panamanian marine cyanobacterium Lyngbya majuscula. J Nat Prod 73(4):709–711
Gutiérrez M, Suyama TL, Engene N, Wingerd JS, Matainaho T, Gerwick WH (2008) Apratoxin D, a potent cytotoxic cyclodepsipeptide from Papua New Guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida. J Nat Prod 71(6):1099–1103
Habekost RC, Fraser IM, Halstead BW (1955) Observations on toxic marine algae. J Wash Acad Sci 45(4):101–103
Hällfors G (2004) Checklist of Baltic Sea phytoplankton species (including some heterotrophic protistan groups). HELCOM Baltic Sea Environ Proc 95:1–208
Hamilton GS, Fielding F, Chiffings AW, Hart BT, Johnstone RW, Mengersen K (2007) Investigating the use of a Bayesian network to model the risk of Lyngbya majuscula bloom initiation in Deception Bay, Queensland Australia. Hum Ecol Risk Assess 13(6):1271–1287
Han B, Gross H, Goeger DE, Mooberry SL, Gerwick WH (2006) Aurilides B and C, cancer cell toxins from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod 69(4):572–575
Han B, Gross H, McPhail KL, Goeger D, Maier CS, Gerwick WH (2011) Wewakamide A and guineamide G, cyclic depsipeptides from the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula. J Microbiol Biotechnol 21(9):930–936
Han B, McPhail KL, Gross H, Goeger DE, Mooberry SL, Gerwick WH (2005) Isolation and structure of five lyngbyabellin derivatives from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. Tetrahedron 61(49):11723–11729
Hanington P, Rose A, Johnstone R (2016) The potential of benthic iron and phosphorus fluxes to support the growth of a bloom forming toxic cyanobacterium Lyngbya majuscula, Moreton Bay Australia. Mar Freshw Res 67(12):1918–1927
Haroun RJ, Gil-Rodríguez MC, Castro JDD, Reine WPHV (2002) A checklist of the marine plants from the Canary Islands (central eastern Atlantic Ocean). Bot Mar 45:139–169
Harrigan GG, Yoshida WY, Moore RE, Nagle DG, Park PU, Biggs J, Paul VJ, Mooberry SL, Corbett TH, Valeriote FA (1998) Isolation, structure determination, and biological activity of dolastatin 12 and lyngbyastatin 1 from Lyngbya majuscula/Schizothrix calcicola cyanobacterial assemblages. J Nat Prod 61(10):1221–1225
Havens KE (2008) Cyanobacteria blooms: effects on aquatic ecosystems. Cyanobacterial harmful algal blooms: state of the science and research 619:733–747
Heath M, Wood SA, Young RG, Ryan KG (2016) The role of nitrogen and phosphorus in regulating Phormidium sp. (cyanobacteria) growth and anatoxin production. FEMS Microbiol Ecol 92(3):fiw021
Hellweger FL, Kravchuk ES, Novotny V, Gladyshev MI (2008) Agent-based modeling of the complex life cycle of a cyanobacterium (Anabaena) in a shallow reservoir. Limnol Oceanogr 53(4):1227–1241
Henderson RJF (2002) Names and distribution of Queensland plants, algae, and lichens. Environmental Protection Agency, Queensland Herbarium
Hewson I, Govil SR, Capone DG, Carpenter EJ, Fuhrman JA (2004) Evidence of Trichodesmium viral lysis and potential significance for biogeochemical cycling in the oligotrophic ocean. Aquat Microb Ecol 36(1):1–8
Hewson I, O’Neil JM, Dennison WC (2001) Virus-like particles associated with Lyngbya majuscula (Cyanophyta; Oscillatoriacea) bloom decline in Moreton Bay Australia. Aquat Microbial Ecol 25(3):207–213
Hooper GJ, Orjala J, Schatzman RC, Gerwick WH (1998) Carmabins A and B, new lipopeptides from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod 61(4):529–533
Howe MA (1932) Marine algae from the islands of Panay and Negros (Philippines) and Niuafoou (between Samoa and Fiji). J Wash Acad Sci 22(7):167–170
Huang SF (2006) Benthic marine algae of Lan-Yu (Orchid Island), Taiwan. 國立臺灣博物館學刊 59(2):19-50
Huisman JM, Abbott IA, Smith CM (2007) Hawaiian reef plants. pp. [1]-264. University of Hawaii Sea Grant College Program
Jaiswal AG (2017) Algae of North-West Khandesh, 1–448. Laxmi Book Publication, Solapur
Jansson M, Olsson H, Pettersson K (1988) Phosphatases; origin, characteristics and function in lakes. In Phosphorus in Freshwater Ecosystems (pp. 157–175). Springer, Dordrecht
Jiang W, Tan S, Hanaki Y, Irie K, Uchida H, Watanabe R, Suzuki T, Sakamoto B, Kamio M, Nagai H (2014a) Two new lyngbyatoxin derivatives from the cyanobacterium. Moorena Producens Marine Drugs 12(12):5788–5800
Jiang W, Zhou W, Othman R, Uchida H, Watanabe R, Suzuki T, Sakamoto B, Nagai H (2018) A new malyngamide from the marine cyanobacterium Moorea producens. Nat Prod Res 32(1):97–104
Jiang W, Zhou W, Uchida H, Kikumori M, Irie K, Watanabe R, Suzuki T, Sakamoto B, Kamio M, Nagai H (2014b) A new lyngbyatoxin from the Hawaiian cyanobacterium Moorea producens. Mar Drugs 12(5):2748–2759
Jiménez JI, Vansach T, Yoshida WY, Sakamoto B, Pörzgen P, Horgen FD (2009) Halogenated fatty acid amides and cyclic depsipeptides from an eastern Caribbean collection of the cyanobacterium Lyngbya majuscula. J Nat Prod 72(9):1573–1578
John DM, Whitton BA, Brook AJ (Eds) (2002) The freshwater algal flora of the British Isles: an identification guide to freshwater and terrestrial algae. Cambridge University Press
Jöhnk KD, Brüggemann R, Rücker J, Luther B, Simon U, Nixdorf B, Wiedner C (2011) Modelling life cycle and population dynamics of Nostocales (cyanobacteria). Environ Model Softw 26(5):669–677
Johnson S, Abal E, Ahern K, Hamilton G (2014) From science to management: using bayesian networks to learn about “Lyngbya”. Stat Sci 36–41
Johnson S, Fielding F, Hamilton G, Mengersen K (2010) An integrated Bayesian network approach to Lyngbya majuscula bloom initiation. Mar Environ Res 69(1):27–37
Kawaguchi M, Satake M, Zhang BT, Xiao YY, Fukuoka M, Uchida H, Nagai H (2020) Neo-aplysiatoxin A isolated from Okinawan cyanobacterium Moorena producens. Molecules 25(3):457
Kerksiek K, Mejillano MR, Schwartz RE, Georg GI, Himes RH (1995) Interaction of cryptophycin 1 with tubulin and microtubules. FEBS Lett 377(1):59–61
Kleinteich J, Wood SA, Küpper FC, Camacho A, Quesada A, Frickey T, Dietrich DR (2012) Temperature-related changes in polar cyanobacterial mat diversity and toxin production. Nat Clim Chang 2(5):356–360
Koehn FE, Longley RE, Reed JK (1992) Microcolins A and B, new immunosuppressive peptides from the blue-green alga Lyngbya majuscula. J Nat Prod 55(5):613–619
Kokociński M, Akçaalan R, Salmaso N, Stoyneva-Gärtner MP, Sukenik A (2017) Expansion of alien and invasive cyanobacteria. Handbook of cyanobacterial monitoring and cyanotoxin analysis. United Kingdom: John Wiley & Sons, 28–39
Kuffner IB, Paul VJ (2001) Effects of nitrate, phosphate and iron on the growth of macroalgae and benthic cyanobacteria from Cocos Lagoon, Guam. Mar Ecol Prog Ser 222:63–72
Kümmerer K (2010) Pharmaceuticals in the environment. Annu Rev Environ Resour 35:57–75
Kwan JC, Eksioglu EA, Liu C, Paul VJ, Luesch H (2009) Grassystatins A− C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem 52(18):5732–5747
Kwan JC, Teplitski M, Gunasekera SP, Paul VJ, Luesch H (2010) Isolation and biological evaluation of 8-epi-malyngamide C from the Floridian marine cyanobacterium Lyngbya majuscula. J Nat Prod 73(3):463–466
Lance E, Brient L, Bormans M, Gérard C (2006) Interactions between cyanobacteria and gastropods: I. Ingestion of toxic Planktothrix agardhii by Lymnaea stagnalis and the kinetics of microcystin bioaccumulation and detoxification. Aquat Toxicol 79(2):140–148
Latysheva N, Junker VL, Palmer WJ, Codd GA, Barker D (2012) The evolution of nitrogen fixation in cyanobacteria. Bioinformatics 28(5):603–606
Lázaro e Ibiza B (1889). Datos para la flora algológica del Norte y Noroeste de España. Anales de la Sociedad Española de Historia Natural 18:275-294
Lehtimaki J, Moisander P, Sivonen K, Kononen K (1997) Growth, nitrogen fixation, and nodularin production by two Baltic Sea cyanobacteria. Appl Environ Microbiol 63(5):1647–1656
Le Vu B, Vinçon-Leite B, Lemaire BJ, Bensoussan N, Calzas M, Drezen C, Deroubaix JF, Escoffier N, Degres Y, Freissinet C, Groleau A (2011) High-frequency monitoring of phytoplankton dynamics within the European water framework directive: application to metalimnetic cyanobacteria. Biogeochemistry 106(2):229–242
Levert A, Alvariño R, Bornancin L, Abou Mansour E, Burja AM, Genevière AM, Bonnard I, Alonso E, Botana L, Banaigs B (2018) Structures and activities of tiahuramides A-C, cyclic depsipeptides from a Tahitian collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod 81(6):1301–1310
Liao LM, Belleza DFC, Geraldino PJL (2013) Marine algae of the Sulu Sea Islands, Philippines II: annotated list of the brown seaweeds (Phaeophyceae) from the Cuyo Islands. Phytotaxa 152(1):1–17
Lipkin Y, Silva PC (2002) Marine algae and seagrasses of the Dahlak Archipelago, southern Red Sea. Nova Hedwigia 75(1–2):1–90
Littler DS (2000) Caribbean reef plants. An identification guide to the reef plants of the Caribbean, Bahamas, Florida and Gulf of Mexico. pp. 542. Offshore Graphics. Inc., Washington, DC
Littler DS, Hanisak MD, Littler MM (2008) Submersed plants of the Indian River Lagoon: a floristic inventory and field guide. Offshore Graphics. Inc., Washington, DC, p 542
Littler MM, Littler DS (1997) An illustrated marine flora of the Pelican Cays. Bulletin of the biological society of Washington, Belize
Liu X, Xu F, Shao C, She Z, Lin Y, Chan WL (2008) Bioactive metabolites from marine microorganisms. Stud Nat Prod Chem 35:197–310
Lobban CS, Tsuda RT (2003) Revised checklist of benthic marine macroalgae and seagrasses of Guam and Micronesia. Micronesica 35(36):54–99
Lopez JA, Al-Lihaibi SS, Alarif WM, Abdel-Lateff A, Nogata Y, Washio K, Morikawa M, Okino T (2016) Wewakazole B, a cytotoxic cyanobactin from the cyanobacterium Moorea producens collected in the Red Sea. J Nat Prod 79(4):1213–1218
Luesch H, Pangilinan R, Yoshida WY, Moore RE, Paul VJ (2001a) Pitipeptolides A and B, new cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 64(3):304–307
Luesch H, Yoshida WY, Moore RE, Paul VJ (1999) Lyngbyastatin 2 and norlyngbyastatin 2, analogues of dolastatin G and nordolastatin G from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 62(12):1702–1706
Luesch H, Yoshida WY, Moore RE, Paul VJ (2000) Apramides A− G, novel lipopeptides from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 63(8):1106–1112
Luesch H, Yoshida WY, Moore RE, Paul VJ (2002) New apratoxins of marine cyanobacterial origin from Guam and Palau. Bioorg Med Chem 10(6):1973–1978
Luesch H, Yoshida WY, Moore RE, Paul VJ, Corbett TH (2001b) Total structure determination of apratoxin A, a potent novel cytotoxin from the marine cyanobacterium Lyngbya majuscula. J Am Chem Soc 123(23):5418–5423
Lyle L (1920) The marine algae of Guernsey. J Bot 58:1–53
Magalhaes VD, Marinho MM, Domingos P, Oliveira AC, Costa SM, Azevedo LD, Azevedo SM (2003) Microcystins (cyanobacteria hepatotoxins) bioaccumulation in fish and crustaceans from Sepetiba Bay (Brasil, RJ). Toxicon 42(3):289–295
Magruder WH, Hunt JW (1979) Seaweeds of Hawaii. Oriental Publishing Company, Honolulu, Hawaii, p 116
Malloy KL, Villa FA, Engene N, Matainaho T, Gerwick L, Gerwick WH (2011) Malyngamide 2, an oxidized lipopeptide with nitric oxide inhibiting activity from a Papua New Guinea marine cyanobacterium. J Nat Prod 74(1):95–98
Mandal S, Rath J, Adhikary SP (2011) Adaptation strategies of the sheathed cyanobacterium Lyngbya majuscula to ultraviolet-B. J Photochem Photobiol, B 102(2):115–122
Marner FJ, Moore RE, Hirotsu K, Clardy J (1977) Majusculamides A and B, two epimeric lipodipeptides from Lyngbya majuscula Gomont. J Org Chem 42(17):2815–2819
Márquez B, Verdier-Pinard P, Hamel E, Gerwick WH (1998) Curacin D, an antimitotic agent from the marine cyanobacterium Lyngbya majuscula. Phytochemistry 49(8):2387–2389
Marshall KL, Vogt RL (1998) Illness associated with eating seaweed, Hawaii, 1994. West J Med 169(5):293
Martín-García L, Herrera R, Moro-Abad L, Sangil C, Barquín-Diez J (2014) Predicting the potential habitat of the harmful cyanobacteria Lyngbya majuscula in the Canary Islands (Spain). Harmful Algae 34:76–86
Maulood BK, Hassan FM, Al-Lami AA, Toma JJ, Ismail AM (2013) Checklist of algal flora in Iraq. Ministry of Environment, Baghdad. pp. 94
Mazur-Marzec H, Żeglińska L, Pliński M (2005) The effect of salinity on the growth, toxin production, and morphology of Nodularia spumigena isolated from the Gulf of Gdańsk, southern Baltic Sea. J Appl Phycol 17(2):171–179
McPhail KL, Correa J, Linington RG, González J, Ortega-Barría E, Capson TL, Gerwick WH (2007) Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. J Nat Prod 70(6):984–988
Mendoza-González AC, Mateo-Cid LE, García-López DY (2017) Inventory of benthic marine and estuarine algae and cyanobacteria for Tabasco, Mexico. Biota Neotropica 17:1–14
Menezes M, Bicudo CE, Moura CW, Alves AM, Santos AA, Pedrini ADG, Araújo A, Tucci A, Fajar A, Malone C, Kano CH (2015) Update of the Brazilian floristic list of algae and cyanobacteria. Rodriguésia 66:1047–1062
Mesguiche V, Valls R, Piovetti L, Peiffer G (1999) Characterization and synthesis of (−)-7-methoxydodec-4 (E)-enoic acid, a novel fatty acid isolated from Lyngbya majuscula. Tetrahedron Lett 40(42):7473–7476
Mevers E, Byrum T, Gerwick WH (2013) Parguerene and precarriebowmide, two classes of lipopeptides from the marine cyanobacterium Moorea producens. J Nat Prod 76(9):1810–1814
Milligan KE, Marquez BL, Williamson RT, Gerwick WH (2000a) Lyngbyabellin B, a toxic and antifungal secondary metabolite from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 63(10):1440–1443
Milligan KE, Marquez B, Williamson RT, Davies-Coleman M, Gerwick WH (2000b) Two new malyngamides from a Madagascan Lyngbya majuscula. J Nat Prod 63(7):965–968
Miranda González F (1931) Sobre las algas Cianofíceas del Cantábrico, especialmente de Gijón. Trabajos Del Museo De Ciencias Naturales De Madrid (serie Botánica) 25:1–106
Miranda F (1934) Materiales para una flora marina de las rı ́as bajas gallegas. Boletı ́n de la Real Sociedad Espan ̃ola de Historia Natural, Seccio ́n Biologı ́a 34:165–180
Miranda SV (2004) Catálogo de las Cyanophyta contenidas en los tubos y preparaciones microscópicas de la colección de F. Miranda. Boletín De Ciencias De La Naturaleza 49:77–89
Mitchell SS, Faulkner DJ, Rubins K, Bushman FD (2000) Dolastatin 3 and two novel cyclic peptides from a Palauan collection of Lyngbya majuscula. J Nat Prod 63(2):279–282
Mohamed ZA, Al-Shehri AM (2015) Biodiversity and toxin production of cyanobacteria in mangrove swamps in the Red Sea off the southern coast of Saudi Arabia. Bot Mar 58(1):23–34
Mohanty N, Vass I, Demeter S (1989) Copper toxicity affects photosystem II electron transport at the secondary quinone acceptor QB. Plant Physiol 90(1):175–179
Molinski TF (2010) NMR of natural products at the ‘nanomole-scale.’ Nat Prod Rep 27(3):321–329
Montaser R, Abboud KA, Paul VJ, Luesch H (2011a) Pitiprolamide, a proline-rich dolastatin 16 analogue from the marine cyanobacterium Lyngbya majuscula from Guam. J Nat Prod 74(1):109–112
Montaser R, Paul VJ, Luesch H (2011b) Pitipeptolides C-F, antimycobacterial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula from Guam. Phytochemistry 72(16):2068–2074
Moore RE (1981) Toxins from marine blue-green algae. W.W. Carmichael (Ed.) In The water environment-Algal Toxins and Health (pp. 15–23). Springer, Boston, MA
Moore RE, Entzeroth M (1988) Majusculamide D and deoxymajusculamide D, two cytotoxins from Lyngbya majuscula. Phytochemistry 27(10):3101–3103
Morgan JB, Liu Y, Coothankandaswamy V, Mahdi F, Jekabsons MB, Gerwick WH, Valeriote FA, Zhou YD, Nagle DG (2015) Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells. Mar Drugs 13(3):1552–1568
Moss NA, Seiler G, Leão TF, Castro-Falcón G, Gerwick L, Hughes CC, Gerwick WH (2019) Nature’s combinatorial biosynthesis produces vatiamides A-F. Angew Chem 131(27):9125–9129
Mynderse JS, Moore RE, Kashiwagi M, Norton TR (1977) Antileukemia activity in the Oscillatoriaceae: isolation of debromoaplysiatoxin from Lyngbya. Science 196(4289):538–540
Mynderse JS, Moore RE (1978) Malyngamides D and E, two trans-7-methoxy-9-methylhexadec-4-enamides from a deep water variety of the marine cyanophyte Lyngbya majuscula. J Org Chem 43(22):4359–4363
Mynderse JS, Hunt AH, Moore RE (1988) 57-Normajusculamide C, a minor cyclic depsipeptide isolated from Lyngbya majuscula. J Nat Prod 51(6):1299–1301
Nagai H, Sato S, Iida K, Hayashi K, Kawaguchi M, Uchida H, Satake M (2019a) Oscillatoxin I: a new aplysiatoxin derivative, from a marine cyanobacterium. Toxins 11(6):366
Nagai H, Watanabe M, Sato S, Kawaguchi M, Xiao YY, Hayashi K, Watanabe R, Uchida H, Satake M (2019b) New aplysiatoxin derivatives from the Okinawan cyanobacterium Moorea producens. Tetrahedron 75(17):2486–2494
Nagarajan M, Maruthanayagam V, Sundaram KM, Sundararaman M (2020) Tropical marine cyanobacterium Lyngbya sordida producing toxic octacosa–1, 27-diene induces coagulative hepatic necrosis and progressive glomerulonephritis in Mus musculus. Encyclopedia Mar Biotechnol 4:2339–2364
Nagle DG, Paul VJ (1998) Chemical defense of a marine cyanobacterial bloom. J Exp Mar Biol Ecol 225(1):29–38
Nagle DG, Camacho FT, Paul VJ (1998) Dietary preferences of the opisthobranch mollusc Stylocheilus longicauda for secondary metabolites produced by the tropical cyanobacterium Lyngbya majuscula. Marine Biology 132(2):267–273
Nagle DG, Zhou YD, Park PU, Paul VJ, Rajbhandari I, Duncan CJ, Pasco DS (2000) A new indanone from the marine cyanobacterium Lyngbya majuscula that inhibits hypoxia-induced activation of the VEGF promoter in Hep3B cells. J Nat Prod 63(10):1431–1433
Nagai S, Chen H, Kawakami Y, Yamamoto K, Sildever S, Kanno N, Oikawa H, Yasuike M, Nakamura Y, Hongo Y, Fujiwara A (2019c) Monitoring of the toxic dinoflagellate Alexandrium catenella in Osaka Bay, Japan using a massively parallel sequencing (MPS)-based technique. Harmful Algae 89:101660
Narayana S (2016) Isolation and characterization of toxic marine cyanobacteria from Andaman and Nicobar Islands, India. pp. 20–40. (Doctoral dissertation)
Nassar MZA, Khairy HM (2014) Checklist of phytoplankton species in the Egyptian waters of the Red Sea and some surrounding habitats (1990–2010). Ann Res Rev Biol 4(23):3566–3585
Ng CSL, Ong LJ, Chou LM (2012) Lyngbya majuscula blooms in an enclosed marine environment. Environ Asia 5(2):93–98
Nguyen HD (1999) Rong biển phụ sinh (Epiphytes) trên cỏ biển ở Khánh Hòa. Tuyển tập Nghiên cứu biển IX. Coll Mả Res Works 9: 196–204
Nguyen HD, Huynh QN, Tran NB, Nguyen VT (1993) Marine algae of North Vietnam (Rong biển phía Bắc Việt Nam), (pp. 344). Science and Technical Publishing House, Hanoi, Vietnam.
Nogle LM, Gerwick WH (2002) Isolation of four new cyclic depsipeptides, antanapeptins A− D, and dolastatin 16 from a Madagascan collection of Lyngbya majuscula. J Nat Prod 65(1):21–24
Nogle LM, Gerwick WH (2003) Diverse secondary metabolites from a Puerto Rican collection of Lyngbya majuscula. J Nat Prod 66(2):217–220
Nogle LM, Marquez BL, Gerwick WH (2003) Wewakazole, a novel cyclic dodecapeptide from a Papua New Guinea Lyngbya majuscula. Org Lett 5(1):3–6
Nogle LM, Okino T, Gerwick WH (2001a) Antillatoxin B, a neurotoxic lipopeptide from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 64(7):983–985
Nogle LM, Williamson RT, Gerwick WH (2001b) Somamides A and B, two new depsipeptide analogues of dolastatin 13 from a Fijian cyanobacterial assemblage of Lyngbya majuscula and Schizothrix Species. J Nat Prod 64(6):716–719
Nyiro C, Dzeha T, Mwafaida JM, Mburu D (2018) Evaluation of UV-resistance of epibiotic bacteria co-existing with the Kenyan marine Lyngbya majuscula. Kenya Aquatica Journal 4(1):13–15
N’Yeurt AD, Payri CE (2004) A preliminary annotated checklist of the marine algae and seagrasses of the Wallis Islands (French Overseas Territory of Wallis and Futuna) South Pacific. Aust Syst Bot 17(4):367–397
Ohba H, Victor S, Golbuu Y, Yukihara H (2007) Tropical marine plants of Palau. (pp. 1–153). Koror: Palau International Coral Reef Center; Japan International Cooperation Agency
Oliveira Filho ECD (1977) Algas marinhas bentônicas do Brasil. pp. 1–120. (Doctoral dissertation, Universidade de São Paulo)
O’Neil JM, Dennison WC (2005) Lyngbya majuscula in Southeast Queensland waterways. In ABAL E and DENNISON WC (Eds), Healthy catchment, healthy waterways. Brisbane: South East Queensland Regional Water Quality Strategy, Brisbane City Council, Brisbane, Australia pp. 119–148
Orjala J, Gerwick WH (1996) Barbamide, a chlorinated metabolite with molluscicidal activity from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod 59(4):427–430
Orjala J, Gerwick WH (1997) Two quinoline alkaloids from the Caribbean cyanobacterium Lyngbya majuscula. Phytochemistry 45(5):1087–1090
Orjala J, Nagle DG, Hsu V, Gerwick WH (1995a) Antillatoxin: an exceptionally ichthyotoxic cyclic lipopeptide from the tropical cyanobacterium Lyngbya majuscula. J Am Chem Soc 117(31):8281–8282
Orjala J, Nagle D, Gerwick WH (1995b) Malyngamide H, an ichthyotoxic amide possessing a new carbon skeleton from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod 58(5):764–768
Ortegon-Aznar I, Leon-Tejera H, Gold-Morgan M, Ramírez-Miss N (2008) Preliminary results on marine algae of Madagascar Reef, Yucatan, México: a functional group approach. In: Proceedings of the 11th International Coral Reef Symposium; July 7-11. Ft. Lauderdale (FL): National Coral Reef Institute. pp. 1373–1376
Osborne NJ, Shaw GR, Webb PM (2007) Health effects of recreational exposure to Moreton Bay, Australia waters during a Lyngbya majuscula bloom. Environ Int 33(3):309–314
Osborne N, Seawright A, Shaw G (2008) Dermal toxicology of Lyngbya majuscula, from Moreton Bay, Queensland Australia. Harmful Algae 7(5):584–589
Papenfuss GF (1968) History, catalogue, and bibliography of Red Sea benthic algae. Isr J Bot 17:1–118
Pavlin BI, Musto J, Pretrick M, Sarofalpiy J, Sappa P, Shapucy S, Kool J (2015) Mass poisoning after consumption of a hawksbill turtle, Federated States of Micronesia, 2010. West Pac Surveill Response J: WPSAR 6(1):25
Payri CE, N’Yeurt ADR (1997) A revised checklist of Polynesian benthic marine algae. Aust Syst Bot 10(6):867–910
Payri CE, N'Yeurt ADR, Orempuller J (2000) Algae of French Polynesia. Algues de Polynésie française, (pp. 320). Tahiti: Au Vent des Iles Editions
Pellizzari F, Osaki VS, Santos-Silva MC (2020) New records of seaweeds and filamentous cyanobacteria from Trindade Island: an updated checklist to support conservation guidelines and monitoring of environmental changes in the southern Atlantic archipelagos. Sci Mar 84(3):227–242
Peña V, Bárbara I (2008) Maërl community in the north-western Iberian Peninsula: a review of floristic studies and long-term changes. Aquat Conserv Mar Freshwat Ecosyst 18(4):339–366
Peralta JP, Garibay SS, Espina RMM, Noble JRN, Nualla AN (2006) An investigation of the algal bloom occurrence in the coastal waters of Barangay Kirayan Norte, Miag-ao, Iloilo Philippines. Philipp Agric Sci 89(1):97
Pittman SJ, Pittman KM (2005) Short-term consequences of a benthic cyanobacterial bloom (Lyngbya majuscula Gomont) for fish and penaeid prawns in Moreton Bay (Queensland, Australia). Estuar Coast Shelf Sci 63(4):619–632
Pollard PC, Young LM (2010) Lake viruses lyse cyanobacteria, Cylindrospermopsis raciborskii, enhances filamentous-host dispersal in Australia. Acta Oecologica 36(1):114–119
Polunin NVC, Klumpp DW (1989) Ecological correlates of foraging periodicity in herbivorous reef fishes of the Coral Sea. J Exp Mar Biol Ecol 126(1):1–20
Popplewell WL, Ratnayake R, Wilson JA, Beutler JA, Colburn NH, Henrich CJ, McMahon JB, McKee TC (2011) Grassypeptolides F and G, cyanobacterial peptides from Lyngbya majuscula. J Nat Prod 74(8):1686–1691
Poulin M, Hamilton PB, Proulx M (1995) Catalogue des algues d’eau douce du Quebec Canada. Can Field Nat 109(1):27–110
Praud A, Valls R, Piovetti L, Banaigs B (1993) Malyngamide G: Proposition de structure pour un nouvel amide chloré d’une algue bleu-verte epiphyte de Cystoseira crinita. Tetrahedron Lett 34(34):5437–5440
Pulido GD, Ruíz MD (2003) Diversity of benthic marine algae of the Colombian Atlantic. Biota Colombiana 4(2):203–246
Rai SK, Rai RK, Jha S (2010) Cyanobacteria of Nepal: a checklist with distribution. Our Nature 8(1):336–354
Rao PSN, Gupta RK (2015) Algae of India Volume 3: a checklist of Indian marine algae (excluding diatoms & dinoflagellate). Botanical survey of india ministry of environment, forests & climate change government of India, Salt Lake and Kolkata
Reinbold T (1896) Meeresalgen (Schizophyceae, Chlorophyceae, Phaeophyceae, Rhodophyceae). Die Flora der Samoa-Inseln. Botanische Jahrbücher Fur Systematik 23:266–275
Reinbold T (1907) I. Meersalgen. In K. Rechinger, Wisseschaftlichen Forschungsreise nach den Samoa-Inseln, dem NeuGuinea-Archipel und den Salomons-Inseln. Botanische Und Zoologisch Ergebnisse 1:200–208
Reinhold T (1937) La flore fossile à diatomées de Moliro (Lac Tanganyika, Katanga). Annales de la Sociéte Géologique de Belgique, Mémoires 61(1):39–47
Robinson CP, Franz DR, Bondura ME (1991) Effects of lyngbyatoxin A from the blue-green alga Lyngbya majuscula on rabbit aorta contractions. Toxicon 29(8):1009–1017
Rose AL, Salmon TP, Lukondeh T, Neilan BA, Waite TD (2005) Use of superoxide as an electron shuttle for iron acquisition by the marine cyanobacterium Lyngbya majuscula. Environ Sci Technol 39(10):3708–3715
Sabry OM, Goeger DE, Gerwick WH (2017) Biologically active new metabolites from a Florida collection of Moorena producens. Nat Prod Res 31(5):555–561
Sauvageau C (1897) Note préliminaire sur les algues marines du Golfe de Gascogne. J. Botanique, 11:166–230
Sen, N. S. (2003). Taxonomy and ecology of the algal flora of Sundarbans Mangals in West Bengal India with special reference to estimation of their contribution to the primary productivity of the estuarine ecosystems (Doctoral dissertation, University of Calcutta).
Seoane-Camba J (1964) Estudios sobre las algas bentónicas en la costa sur de la Península Ibérica (litoral de Cádiz). Investigacion Pesquera Tomo 29:3–216
Setchell WA (1924) American Samoa. Part 1. Vegetation of Tutuila Island. Part 2. Ethnobotany of the Samoans. Part 3. Vegetation of Rose Atoll, 20:165–167. Carnegie Institution of Washington.
Setchell WA, Gardner NL (1930) Marine algae of the Revillagigedo Islands Expedition in 1925. Proc Calif Acad Sci Ser 4,19:109–215
Shaala LA, Youssef DT, McPhail KL, Elbandy M (2013) Malyngamide 4, a new lipopeptide from the Red Sea marine cyanobacterium Moorea producens (formerly Lyngbya majuscula). Phytochem Lett 6(2):183–188
Shi K, Zhang Y, Qin B, Zhou B (2019) Remote sensing of cyanobacterial blooms in inland waters: present knowledge and future challenges. Sci Bull 64(20):154
Sidelev S, Koksharova O, Babanazarova O, Fastner J, Chernova E, Gusev E (2020) Phylogeographic, toxicological and ecological evidence for the global distribution of Raphidiopsis raciborskii and its northernmost presence in Lake Nero Central Western Russia. Harmful Algae 98:101889
Siva SMF (1991) Cyanophyceae associated with mangrove trees at Inhaca Island Mozambique. Bothalia 21(2):143–150
Silva PC, Basson PW, Moe RL (1996) Catalogue of the benthic marine algae of the Indian Ocean (Vol. 79). Univ Calif. Publ Bot, 79:1–1259
Simis SG, Tijdens M, Hoogveld HL, Gons HJ (2005) Optical changes associated with cyanobacterial bloom termination by viral lysis. J Plankton Res 27(9):937–949
Singh IP, Milligan KE, Gerwick WH (1999) Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 62(9):1333–1335
Sitachitta N, Márquez BL, Williamson RT, Rossi J, Roberts MA, Gerwick WH, Nguyen VA, Willis CL (2000a) Biosynthetic pathway and origin of the chlorinated methyl group in barbamide and dechlorobarbamide, metabolites from the marine cyanobacterium Lyngbya majuscula. Tetrahedron 56(46):9103–9113
Sitachitta N, Gerwick WH (1998) Grenadadiene and grenadamide, cyclopropyl-containing fatty acid metabolites from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 61(5):681–684
Sitachitta N, Williamson RT, Gerwick WH (2000b) Yanucamides A and B, two new depsipeptides from an assemblage of the marine cyanobacteria Lyngbya majuscula and Schizothrix species. J Nat Prod 63(2):197–200
Skuja H (1949) Zur Susswassralgenflora Burmas. Nova Acta Regiae Societatis Scientiarum Upsaliensis 4(14):1–188
Subbaraju GV, Golakoti T, Patterson GM, Moore RE (1997) Three new cryptophycins from Nostoc sp. GSV 224. J Nat Prod 60(3):302–305
Stal LJ (2015) Nitrogen fixation in cyanobacteria. In: eLS; John Wiley & Sons, Ltd.: Chichester, 1–9
Stal LJ (2007) Cyanobacteria: diversity and versatility, clues to life in extreme environments. In: Seckbach J (ed). In: Algae and cyanobacteria in extreme environments (pp. 659–680). Springer, Dordrecht
Stenina AS, Patova EN (2007) Algae. Systematic lists of species of flora and fauna state natural reserve "Nenetzkij ". St. Petersburg State University, St. Petersburg, pp 5–21
South GR, Skelton PA, Yoshinaga A (2001) Subtidal benthic marine algae of the Phoenix Islands, Republic of Kiribati, central Pacific. Bot Mar 44:559–570
Sueyoshi K, Yamano A, Ozaki K, Sumimoto S, Iwasaki A, Suenaga K, Teruya T (2017) Three new malyngamides from the marine cyanobacterium Moorea producens. Mar Drugs 15(12):367
Sweeney-Jones AM, Gagaring K, Antonova-Koch J, Zhou H, Mojib N, Soapi K, Skolnick J, McNamara CW, Kubanek J (2020) Antimalarial peptide and polyketide natural products from the Fijian marine cyanobacterium Moorea producens. Mar Drugs 18(3):167
Tan LT, Chang YY, Ashootosh T (2008) Besarhanamides A and B from the marine cyanobacterium Lyngbya majuscula. Phytochemistry 69(10):2067–2069
Tan LT, Goh BPL, Tripathi A, Lim MG, Dickinson GH, Lee SSC, Teo SLM (2010) Natural antifoulants from the marine cyanobacterium Lyngbya majuscula. Biofouling 26(6):685–695
Tan LT, Okino T, Gerwick WH (2000) Hermitamides A and B, toxic malyngamide-type natural products from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 63(7):952–955
Tan LT, Sitachitta N, Gerwick WH (2003) The guineamides, novel cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod 66(6):764–771
Taniguchi M, Nunnery JK, Engene N, Esquenazi E, Byrum T, Dorrestein PC, Gerwick WH (2010) Palmyramide A, a cyclic depsipeptide from a Palmyra Atoll collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod 73(3):393–398
Tao Y, Li W, Xue B, Zhong J, Yao S, Wu Q (2013) Different effects of copper (II), cadmium (II) and phosphate on the sorption of phenanthrene on the biomass of cyanobacteria. J Hazard Mater 261:21–28
Taskin E, Akbulut A, Yıldız A, Şahin B, Şen B, Uzunöz C, Solak C, Başdemir D, Çevik F, Sönmez F, Acikgöz Erkaya İLKAY (2019) Türkiye Bitkileri Listesi Suyosunları. Ali Nihat Gökyiğit Vaki, Istanbul
Taylor WR (1928) The marine algae of Florida with special reference to the Dry Tortugas. Papers Tortugas Lab Carnegie Inst Washington 25:1–219
Taylor WR (1945) Pacific marine algae of the Allan Hancock Expeditions to the Galapagos Islands. Allan Hancock Pac Exped 12:1–528
Taylor WR (1950) Plants of Bikini and other northern Marshall Islands. University of Michigan Press, Plants of Bikini and other Northern Marshall Islands
Taylor W (1972) Marine algae of the Smithsonian-Bredin expedition to Yucatán—1960. Bull Mar Sci 22(1):34–44
Titlyanov EA, Titlyanova TV, Yakovleva IM, Sergeeva, OS (2006) Influence of winter and spring/summer algal communities on the growth and physiology of adjacent scleractinian corals
Thacker RW, Nagle DG, Paul VJ (1997) Effects of repeated exposures to marine cyanobacterial secondary metabolites on feeding by juvenile rabbitfish and parrotfish. Mar Ecol Prog Ser 147:21–29
Thajuddin N, Subramanian G (1992) Survey of cyanobacterial flora of the southern east coast of India. Bot Mar 35:305–314
Thajuddin N, Subramanian G (2005) Cyanobacterial biodiversity and potential applications in biotechnology. Curr Sci, 89:47–57
Thornburg CC, Cowley ES, Sikorska J, Shaala LA, Ishmael JE, Youssef DT, McPhail KL (2013) Apratoxin H and apratoxin A sulfoxide from the Red Sea cyanobacterium Moorea producens. J Nat Prod 76(9):1781–1788
Thrush SF, Hewitt JE, Cummings VJ, Ellis JI, Hatton C, Lohrer A, Norkko AJ (2004) Muddy waters: elevating sediment input to coastal and estuarine habitats. Front Ecol Environ 2(6):299–306
Tiling K, Proffitt CE (2017) Effects of Lyngbya majuscula blooms on the seagrass Halodule wrightii and resident invertebrates. Harmful Algae 62:104–112
Titlyanov EA, Titlyanova TV, Huang H, Scriptsova AV, Xu H, Li X (2019) Seasonal changes in the intertidal and subtidal algal communities of extremely and moderately polluted coastal regions of Sanya Bay (Hainan Island, China). J Mar Sci Eng 7(4):93
Todd JS, Gerwick WH (1995a) Isolation of a cyclic carbonate, a γ-butyrolactone, and a new indole derivative from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 58(4):586–589
Todd JS, Gerwick WH (1995b) Malyngamide I from the tropical marine cyanobacterium Lyngbya majuscula and the probable structure revision of stylocheilamide. Tetrahedron Lett 36(43):7837–7840
Trimurtulu G, Ohtani I, Patterson GM, Moore RE, Corbett TH, Valeriote FA, Demchik L (1994) Total structures of cryptophycins, potent antitumor depsipeptides from the blue-green alga Nostoc sp. strain GSV 224. J Am Chem Soc 116(11):4729–4737
Tripathi A, Fang W, Leong DT, Tan LT (2012) Biochemical studies of the lagunamides, potent cytotoxic cyclic depsipeptides from the marine cyanobacterium Lyngbya majuscula. Mar Drugs 10(5):1126–1137
Tripathi A, Puddick J, Prinsep MR, Lee PPF, Tan LT (2009) Hantupeptin A, a cytotoxic cyclic depsipeptide from a Singapore collection of Lyngbya majuscula. J Nat Prod 72(1):29–32
Tripathi A, Puddick J, Prinsep MR, Lee PPF, Tan LT (2010a) Hantupeptins B and C, cytotoxic cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. Phytochemistry 71(2–3):307–311
Tripathi A, Puddick J, Prinsep MR, Rottmann M, Tan LT (2010b) Lagunamides A and B: cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 73(11):1810–1814
Tripathi A, Puddick J, Prinsep MR, Rottmann M, Chan KP, Chen DYK, Tan LT (2011) Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula. Phytochemistry 72(18):2369–2375
Tronholm A (2019) Moorena gen. nov., a valid name for “Moorea Engene & al”. nom. inval. Oscillatoriaceae Cyanobacteria 122:1–2
Tsuda RT (2003) Checklist and bibliography of the marine benthic algae from the Mariana Islands (Guam and CNMI), 107:1–49. University of Guam Marine Laboratory
Tsuda RT (2006) Checklist and bibliography of the marine benthic algae within Chuuk, Pohnpei, and Kosrae States, Federated States of Micronesia. Honolulu, HA: Bishop Museum Pacific Biological Survey, 43 pp.
Tsuda RT (2014) Bibliographic catalogue of the marine benthic algae in the Papahānaumokuākea Marine National Monument (Northwestern Hawaiian Islands). Phytotaxa 167(1):35–60
Tsuda RT, Abbott IA, Foster KB (2006) Marine benthic algae from Wake Atoll. Micronesia-Agana 38(2):207
Tsuda RT, Vroom PS, Abbott IA, Fisher JR, Foster KB (2008) Additional marine benthic algae from Howland and Baker Islands, Central Pacific1. Pac Sci 62(2):271–290
Van Nguyen T, Le NH, Lin SM, Steen F, De Clerck O (2013) Checklist of the marine macroalgae of Vietnam. Botanica marina 56(3):207–227
Von Westernhagen H (1973) The natural food of the rabbitfish Siganus oramin and S striolata. Mar Biol 22(4):367–370
Watkinson AJ, O’Neil JM, Dennison WC (2005) Ecophysiology of the marine cyanobacterium, Lyngbya majuscula (Oscillatoriaceae) in Moreton Bay Australia. Harmful Algae 4(4):697–715
White JD, Hanselmann R, Wardrop DJ (1999) Synthesis of epiantillatoxin, a stereoisomer of the potent ichthyotoxin from Lyngbya majuscula. J Am Chem Soc 121(5):1106–1107
White JD, Kim TS, Nambu M (1997) Absolute configuration and total synthesis of (+)-curacin A, an antiproliferative agent from the cyanobacterium Lyngbya majuscula. J Am Chem Soc 119(1):103–111
White JD, Xu Q, Lee CS, Valeriote FA (2004) Total synthesis and biological evaluation of (+)-kalkitoxin, a cytotoxic metabolite of the cyanobacterium Lyngbya majuscula. Org Biomol Chem 2(14):2092–2102
Wilcox MD (2007) A summer bloom of the marine benthic cyanobacterium Lyngbya majuscula at Musick Point, Eastern Beach and Howick. Auckland Bot Soc J 62:102–103
Williams DE, Burgoyne DL, Rettig SJ, Andersen RJ, Fathi-Afshar ZR, Allen TM (1993) The isolation of Majusculamide C from the sponge Ptilocaulis trachys collected in Enewetak and determination of the absolute configuration of the 2-methyl-3-aminopentanoic acid residue. J Nat Prod 56(4):545–551
Williams PG, Moore RE, Paul VJ (2003) Isolation and structure determination of lyngbyastatin 3, a lyngbyastatin 1 homologue from the marine cyanobacterium Lyngbya majuscula. Determination of the configuration of the 4-Amino-2, 2-dimethyl-3-oxopentanoic acid unit in majusculamide C, dolastatin 12, lyngbyastatin 1, and lyngbyastatin 3 from cyanobacteria. J Nat Prod 66(10):1356–1363
Wu M, Milligan KE, Gerwick WH (1997) Three new malyngamides from the marine cyanobacterium Lyngbya majuscula. Tetrahedron 53(47):15983–15990
Xia B & Zhang, J. (1999) Flora algarum marinarum sinicarum Tomus I Cyanophyta, (pp. 1–8). Florarum Cryptogamarum Sinicarum Academiae Sinicae Edita, Science Press, 201 pp. XI
Yoo HD, Gerwick WH (1995) Curacins B and C, new antimitotic natural products from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 58(12):1961–1965
Youssef DT, Shaala LA, Mohamed GA, Ibrahim SR, Banjar ZM, Badr JM, McPhail KL, Risinger AL, Mooberry SL (2015) 2, 3-Seco-2, 3-dioxo-lyngbyatoxin A from a Red Sea strain of the marine cyanobacterium Moorea producens. Nat Prod Res 29(8):703–709
Youssef DT, Ibrahim SR, Shaala LA, Mohamed GA, Banjar ZM (2016) New cerebroside and nucleoside derivatives from a Red Sea strain of the marine cyanobacterium Moorea producens. Molecules 21(3):324
Yu HB, Glukhov E, Li Y, Iwasaki A, Gerwick L, Dorrestein PC, Jiao BH, Gerwick WH (2019) Cytotoxic microcolin lipopeptides from the marine cyanobacterium Moorea producens. J Nat Prod 82(9):2608–2619
Zhu H (2007) Flora Algarum Sinicarum Aquae Dulcis (Tomus IX): Cyanophyta Hormogonophyceae. Science Press, Beijing, pp 1–312
Zubia M, Turquet J, Golubic S (2016) Benthic cyanobacterial diversity of iles eparses (scattered islands) in the Mozambique channel. Acta Oecologica 72:21–32
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This work was partially supported by funds awarded to Dr. Sandric Leong through the National University of Singapore and was made possible because of the support of members of Team HABs.
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All authors contributed to the work equally. Material preparation and data collection was conducted by Emily Curren. The first draft of the manuscript was vetted by Sandric Leong Chee Yew and all authors commented and edited previous versions of the manuscript. All authors red and approved the final manuscript.
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Curren, E., Leaw, C.P., Lim, P.T. et al. The toxic cosmopolitan cyanobacteria Moorena producens: insights into distribution, ecophysiology and toxicity. Environ Sci Pollut Res 29, 78178–78206 (2022). https://doi.org/10.1007/s11356-022-23096-4
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DOI: https://doi.org/10.1007/s11356-022-23096-4