Abstract
The contamination level of 12 antibiotics in 8 species of fish and shrimp from the Dongting Lake, China, was firstly studied. In total, the concentrations of antibiotics in fish and shrimp were lower, which were far lower than the maximum residue limits. The most abundant compound was enrofloxacin followed by sulfadiazine, sulfamethoxazole, sarafloxacin, and sulfadimidine with the highest content from 0.37 to 1.06 ng g−1. The concentrations in Silurus asotus, Cyprinus carpio, and Palinuridae were higher. Concentrations in fish and shrimp from different water layers showed spatial difference, with the order of benthos and middle-lower species > middle-upper species. In addition, the antibiotic content could be affected by the diet, which showed the concentration level of antibiotics decreased in the order of carnivorous > omnivorous > phytophagous species. Human health risk assessment based on potential fish consumption indicates that main antibiotic risk factors were enrofloxacin and sarafloxacin, and main risk species were Silurus asotus and Palinuridae. The daily risk quotient of these antibiotics to rural residents was lower than townsmen. This study is the first report of antibiotic content in fish and shrimp from the Dongting Lake, which could enrich the research of emerging pollutants in aquatic products.
Similar content being viewed by others
References
Bai Y, Meng W, Xu J, Zhang Y, Guo C (2014) Occurrence, distribution and bioaccumulation of antibiotics in the Liao River basin in China [J]. Environ Sci: Processes Impacts 16(3):586–593. https://doi.org/10.1039/c3em00567d
Ch P, Thm A (1979) The effect of tetracycline on the teeth of children [M]. Minutes of the General Assembly of the Presbyterian Church in the United States of America, Presbyterian Board of Publication. 53–8
Cleuvers M (2004) Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen and acetylsalicylic acid [J]. Ecotoxicol Environ Saf 59(3):309–315. https://doi.org/10.1016/S0147-6513(03)00141-6
Gao L H, Shi Y L, Li W H, et al. Occurrence, distribution and bioaccumulation of antibiotics in the Haihe River in China [J]. J Environ Monit, 2012, 14(4): 1247–1254
Grossman PL, Remington JS (1979) The effect of trimethoprim and sulfamethoxazole on toxoplasma gondii in vitro and in vivo [J]. Am J Tropical Med Hyg 28(3):445–455. https://doi.org/10.4269/ajtmh.1979.28.445
Hagenbuch IM, Pinckney JL (2012) Toxic effect of the combined antibiotics ciprofloxacin, lincomycin, and tylosin on two species of marine diatoms [J]. Water Res 46(16):5028–5036. https://doi.org/10.1016/j.watres.2012.06.040
Harnisz M, Korzeniewska E, Gołaś I. (2015) The impact of a freshwater fish farm on the community of tetracycline-resistant bacteria and the structure of tetracycline resistance genes in river water[J]. Chemosphere, 128: 134–141.
He XT, Wang Q, Nie XP et al (2014) Residues and health risk assessment of sulfonamides in sediment and fish from typical marine aquaculture regions of Guangdong Province, China [J]. Environ Sci 35(7):2728–2735 (in Chinese)
He X T, Deng M C, Wang Q, et al. Residues and health risk assessment of quinolones and sulfonamides in cultured fish from Pearl River Delta, China [J]. Aquaculture, 2016, 458:38–46, DOI: https://doi.org/10.1016/j.aquaculture.2016.02.006
Islam MS, Ahmed MK, Habibullah-Al-Mamun M, Raknuzzaman M, Ali MM, Eaton DW (2016) Health risk assessment due to heavy metal exposure from commonly consumed fish and vegetables [J]. Environ Sys Decis 36(3):253–265. https://doi.org/10.1007/s10669-016-9592-7
Kan J, Zhu XX, Wang TY et al (2015) Chinese patient demand for intravenous therapy: a preliminary survey [J]. Lancet 386:S61. https://doi.org/10.1016/S0140-6736(15)00642-X
Kasprzykhordern B, Dinsdale RM, Guwy AJ (2009) The removal of pharmaceuticals, personal care products, endocrine disruptors and illicit drugs during wastewater treatment and its impact on the quality of receiving waters.[J]. Water Res 43(2):363–380. https://doi.org/10.1016/j.watres.2008.10.047
Li F, Huang JM, Zeng GH et al (2013) Spatial risk assessment and sources identification of heavy metals in surface sediments from Dongting Lake, Middle China [J]. J Geochem Explor 132(3):75–83. https://doi.org/10.1016/j.gexplo.2013.05.007
Li J, Zhang RJ, Wang RM et al (2016) Distribution characteristics and ecological risk assessment of antibiotic pollution in Xiaoqing River watershed [J]. J Agro-Environ Sci 35(7):1384–1391 (in Chinese)
Luo Y, Xu L, Rysz M, Wang Y, Zhang H, Alvarez PJJ (2011) Occurrence and transport of tetracycline, sulfonamide, quinolone, and macrolide antibiotics in the Haihe River Basin, China [J]. Environ Sci Technol 45(5):1827–1833. https://doi.org/10.1021/es104009s
Ma RX, Wang B, Lu SY et al (2016) Characterization of pharmaceutically active compounds in Dongting Lake, China: occurrence, chiral profiling and environmental risk [J]. Sci Total Environ 557-558:268–275. https://doi.org/10.1016/j.scitotenv.2016.03.053
Marburger JE, Johnson WE, Gross TS et al (2015) Residual organochlorine pesticides in soils and fish from wetland restoration areas in central Florida, USA [J]. Wetlands 22(4):705–711
Martinez JL (2009) Environmental pollution by antibiotics and by antibiotic resistance determinants [J]. Environ Pollut 157(11):2893–2902. https://doi.org/10.1016/j.envpol.2009.05.051
Prabhakaran D, Sukul P, Lamshöft M, Maheswari MA, Zühlke S, Spiteller M (2009) Photolysis of difloxacin and sarafloxacin in aqueous systems [J]. Chemosphere 77(6):739–746. https://doi.org/10.1016/j.chemosphere.2009.08.031
Pulgarín J A M, Molina A A, Ferreras F M, et al. Rapid and simple determination of sarafloxacin in egg by time-resolved chemiluminescence [J]. Food Anal Methods, 2012, 6(4): 1153–1161
Ren K J, Liu Y, Xu J R, et al. Residues characteristics of fluoroquinolones(FQs) in the river sediments and fish tissues in a drinking water protection area of Guangdong Province [J]. Acta Sci Circumst, 2016, 36(3): 760–766. (in Chinese)
Richardson BJ, Lam PK, Martin M (2005) Emerging chemicals of concern: pharmaceuticals and personal care products (PPCPs) in Asia, with particular reference to Southern China [J]. Mar Pollut Bull 50(9):913–920. https://doi.org/10.1016/j.marpolbul.2005.06.034
Rodriguez-Mozaz S, Chamorro S, Marti E, Huerta B., Gros M., Sànchez-Melsió A., Borrego C.M., Barceló D., Balcázar J.L. Occurrence of antibiotics and antibiotic resistance genes in hospital and urban wastewaters and their impact on the receiving river [J]. Water Res, 2014, 69:234–242, DOI: https://doi.org/10.1016/j.watres.2014.11.021
Sanderson H, Brain RA, Johnson DJ, Wilson CJ, Solomon KR (2004) Toxicity classification and evaluation of four pharmaceuticals classes: antibiotics, antineoplastics, cardiovascular, and sex hormones [J]. Toxicology 203(1):27–40. https://doi.org/10.1016/j.tox.2004.05.015
Shi J, Zheng GJS, Wong MH, Liang H, Li Y, Wu Y, Li P, Liu W (2016) Health risks of polycyclic aromatic hydrocarbons via fish consumption in Haimen bay (China), downstream of an e-waste recycling site (Guiyu) [J]. Environ Res 147:233–240. https://doi.org/10.1016/j.envres.2016.01.036
Tamtam F, Mercier F, Bot BL et al (2008) Occurrence and fate of antibiotics in the Seine River in various hydrological conditions [J]. Sci Total Environ 393(1):84–95. https://doi.org/10.1016/j.scitotenv.2007.12.009
Tang J, Shi TZ, Wu XW et al (2014) The occurrence and distribution of antibiotics in Lake Chaohu, China: seasonal variation, potential source and risk assessment [J]. Chemosphere 122:154–161. https://doi.org/10.1016/j.chemosphere.2014.11.032
Veith G D, Defoe D L, Bergstedt B V. Measuring and estimating the bioconcentration factor of chemicals in fish [J]. J Fish Res Board Can, 1979, 36(9):1040–1048, DOI: https://doi.org/10.1139/f79-146
Wang GQ, Sun T (2011) Antibiotic residues in aquatic products of Hongze Lake investigation and research [J]. Guangdong Chemical Industry 38(1):151–153
Wang HZ, Wang CC, Tang J (2015) Investigation of antibiotics residue in aquatic food in Chaohu Lake by HPLC-MS/MS [J]. J Anhui Agric Sci 43(22):94–95 (in Chinese)
Wang D, Sui Q, Zhao WT et al (2014) Pharmaceutical and personal care products in the surface water of China: a review (in Chinese). Chin Sci Bull (Chin Ver) 59(9):743–751. https://doi.org/10.1360/972013-370
Wu C X, Huang X L, Witter J D, et al. Occurrence of pharmaceuticals and personal care products and associated environmental risks in the central and lower Yangtze river, China [J]. Ecotoxicol Environ Saf, 2014, 106:19, 26, DOI: https://doi.org/10.1016/j.ecoenv.2014.04.029
Xu W H, Zhang G, Zou S C, et al. Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry [J]. Environ Pollut, 2007, 145(3): 672–679, DOI: https://doi.org/10.1016/j.envpol.2006.05.038
Xu J, Zhang Y, Zhou C B, et al. Distribution, sources and composition of antibiotics in sediment, overlying water and pore water from Taihu Lake, China [J]. Sci Total Environ, 2014, 497-498(3):267, 273, DOI: https://doi.org/10.1016/j.scitotenv.2014.07.114
Xu X, Zhang K, Wang L, et al. Contamination and distribution of tetracyclines, sulfonamides, quinolones and macrolides in the Haihe River, China [J]. Nat Environ Pollution Technol, 2015a, 14(1):17–24
Xu J, Wang N, Kong D Y, et al. Bioconcentration of sulfonamide antibiotics in zebrafish (Brachydanio rerio ) and model prediction assessment [J]. Asian J Ecotoxicol, 2015b, 10(5): 82–88. (in Chinese)
Yan CX, Yang Y, Zhou JL et al (2013) Antibiotics in the surface water of the Yangtze estuary: occurrence, distribution and risk assessment [J]. Environ Pollut 175(8):22–29. https://doi.org/10.1016/j.envpol.2012.12.008
Yang CQ, Wang LX, Hou XH et al (2012) Analysis of pollution levels of 16 antibiotics in the river water of Daliao River water system [J]. Chin J Chromatogr 30(8):756–762 (in Chinses)
Yuan SG, Cui YF, Zhang WJ (2015) Residual levels of antibiotics in aquatic products in Beijing market [J]. Asian J Ecotoxicol 10(3):311–317 (in Chinese)
Zhang QQ (2015) Emission estimation, multimedia fate modeling and risk assessment of typical emerging pollutants at river basin scale in China [D]. Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou. (in Chinese)
Zhang Q Q, Ying G G, Pan C G, Liu Y.S., Zhao J.L. A comprehensive evaluation of antibiotics emission and fate in the river basins of China: source analysis, multimedia modelling, and linkage to bacterial resistance [J]. Environ Sci Technol, 2015, 49 (11), 6772–6782, DOI: https://doi.org/10.1021/acs.est.5b00729
Zhao JL, Liu YS, Liu WR, Jiang YX, Su HC, Zhang QQ, Chen XW, Yang YY, Chen J, Liu SS, Pan CG, Huang GY, Ying GG (2015) Tissue-specific bioaccumulation of human and veterinary antibiotics in bile, plasma, liver and muscle tissues of wild fish from a highly urbanized region [J]. Environ Pollut 198:15–24. https://doi.org/10.1016/j.envpol.2014.12.026
Funding
This work was financially supported by Ministry of Science and Technology of China (Grant No.2015FY110900). The authors would like to thank the assistance of Prof. Weihao Zhang and Dr. Yixiao Wu.
Author information
Authors and Affiliations
Corresponding author
Additional information
Responsible editor: Philippe Garrigues
Electronic supplementary material
ESM 1
(DOCX 25 kb)
Rights and permissions
About this article
Cite this article
Liu, X., Lu, S., Meng, W. et al. Residues and health risk assessment of typical antibiotics in aquatic products from the Dongting Lake, China—“Did you eat “Antibiotics” today?”. Environ Sci Pollut Res 25, 3913–3921 (2018). https://doi.org/10.1007/s11356-017-0745-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11356-017-0745-0