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Evidence of physical activity interventions on non-motor symptoms of people with Parkinson’s disease: an umbrella review

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Abstract

Background

The aim of this umbrella review was to synthesize evidence from physical activity interventions on non-motor symptoms of people with Parkinson’s disease (PD), as well as to assess the quality of systematic reviews and meta-analyses included.

Methods

The Pubmed, Cochrane Library, Web of Science, ScienceDirect and SCOPUS databases were searched for systematic reviews and meta-analyses that should investigate any type of physical activity in depression, anxiety, mood, sleep disturbances, and cognitive impairment in people with PD. Methodological quality was assessed using AMSTAR.

Results

Twenty systematic reviews met the criteria; most studies were classified as high quality. Strong evidence has shown that different types of physical exercise promote positive results in PD. Most interventions investigated the effects of aerobic exercise and complementary practices, with great emphasis on symptoms of depression and cognition. However, the frequency and duration of these interventions are unclear.

Conclusion

In general, this review suggests that the practice of physical activity should be included as a form of rehabilitation and combined with drug treatment in people with PD.

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References

  1. Cabreira V, Massano J (2019) Doença de Parkinson: Revisão Clínica e Atualização. Acta Med Port 32:661

    Article  CAS  PubMed  Google Scholar 

  2. Reichmann H (2017) Premotor diagnosis of Parkinson’s disease. Neurosci Bull 33:526

    Article  PubMed  PubMed Central  Google Scholar 

  3. Kim H-S, Cheon S-M, Seo J-W, Ryu H-J, Park K-W, Kim JW (2013) Nonmotor symptoms more closely related to Parkinson’s disease: comparison with normal elderly. J Neurol Sci 324:70–73

    Article  PubMed  Google Scholar 

  4. Balestrino R, Schapira AHV (2020) Parkinson disease. Eur J Neurol 27:27–42

    Article  CAS  PubMed  Google Scholar 

  5. Jankovic J, Tan EK (2020) Parkinson’s disease: etiopathogenesis and treatment. J Neurol Neurosurg Psychiatry 91:795–808

    Article  PubMed  Google Scholar 

  6. Reich SG, Savitt JM (2019) Parkinson’s disease. Med Clin North Am 103:337–350

    Article  PubMed  Google Scholar 

  7. Bogosian A, Rixon L, Hurt CS (2020) Prioritising target non-pharmacological interventions for research in Parkinson’s disease: achieving consensus from key stakeholders. Res Involv Engagem. https://doi.org/10.1186/S40900-020-00212-7

    Article  PubMed  PubMed Central  Google Scholar 

  8. Montgomery EB, Lieberman A, Singh G, Fries JF (1994) Patient education and health promotion can be effective in Parkinson’s disease: a randomized controlled trial. Am J Med 97:429–435

    Article  PubMed  Google Scholar 

  9. Granziera S, Alessandri A, Lazzaro A, Zara D, Scarpa A (2020) Nordic Walking and Walking in Parkinson’s disease: a randomized single-blind controlled trial. Aging Clin Exp Res 33(4):965–971

    Article  PubMed  Google Scholar 

  10. Tang L, Fang Y, Yin J (2019) The effects of exercise interventions on Parkinson’s disease: a Bayesian network meta-analysis. J Clin Neurosci 70:47–54

    Article  PubMed  Google Scholar 

  11. Jin X, Wang L, Liu S, Zhu L, Loprinzi PD, Fan X (2020) The impact of mind-body exercises on motor function, depressive symptoms, and quality of life in Parkinson’s disease: a systematic review and meta-analysis. Int J Environ Res Public Health 17(1):31. https://doi.org/10.3390/ijerph17010031

    Article  Google Scholar 

  12. Aromataris E, Fernandez R, Godfrey CM, Holly C, Khalil H, Tungpunkom P (2015) Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach. Int J Evid Based Healthc 13:132–140

    Article  PubMed  Google Scholar 

  13. O’Malley N, Clifford AM, Comber L, Coote S (2020) Effectiveness of non-pharmacological falls prevention interventions for people with multiple sclerosis, Parkinson’s disease and stroke: protocol for an umbrella review. HRB Open Res 3:17

    Article  PubMed  PubMed Central  Google Scholar 

  14. Forte R, Tocci N, De Vito G (2021) The impact of exercise intervention with rhythmic auditory stimulation to improve gait and mobility in Parkinson disease: an umbrella review. Brain Sci 11:685

    Article  PubMed  PubMed Central  Google Scholar 

  15. Paolucci T, Sbardella S, La Russa C et al (2020) Evidence of rehabilitative impact of progressive resistance training (PRT) programs in Parkinson disease: an umbrella review. Parkinsons Dis 2020:1–9

    Article  Google Scholar 

  16. Martignon C, Pedrinolla A, Ruzzante F, Giuriato G, Laginestra FG, Bouça-Machado R, Ferreira JJ, Tinazzi M, Schena F, Venturelli M (2021) Guidelines on exercise testing and prescription for patients at different stages of Parkinson’s disease. Aging Clin Exp Res 33:221–246

    Article  PubMed  Google Scholar 

  17. Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page M, Welch V (2019) Cochrane handbook for systematic reviews of interventions, 2nd edn. Wiley, Chichester

    Book  Google Scholar 

  18. Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression, and mortality. Neurology 17(5):427–442

    Article  CAS  PubMed  Google Scholar 

  19. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan—a web and mobile app for systematic reviews. Syst Rev 5:1–10

    Article  Google Scholar 

  20. Caspersen CJ, Powell KE, Christenson GM (1985) Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep 100:126

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Silva AM (2014) Between the body and the body practices. Arquivos em Movimento

  22. Castillo ARG, Recondo R, Asbahr FR, Manfro GG (2000) Transtornos de ansiedade. Braz J Psychiatry 22:20–23

    Article  Google Scholar 

  23. Freeman L (2014) Toward a phenomenology of mood. South J Philos 52:445–476

    Article  Google Scholar 

  24. Ferber R (1996) Childhood sleep disorders. Neurol Clin 14:493–511

    Article  CAS  PubMed  Google Scholar 

  25. Sharma T, Antonova L (2003) Cognitive function in schizophrenia: deficits, functional consequences, and future treatment. Psychiatr Clin North Am 26:25–40

    Article  PubMed  Google Scholar 

  26. Shea BJ, Hamel C, Wells GA, Bouter LM, Kristjansson E, Grimshaw J, Henry DA, Boers M (2009) AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviews. J Clin Epidemiol 62:1013–1020

    Article  PubMed  Google Scholar 

  27. Guyatt G, Oxman AD, Akl EA et al (2011) GRADE guidelines: 1. Introduction—GRADE evidence profiles and summary of findings tables. J Clin Epidemiol 64:383–394

    Article  PubMed  Google Scholar 

  28. Barry G, Galna B, Rochester L (2014) The role of exergaming in Parkinson’s disease rehabilitation: a systematic review of the evidence. J Neuroeng Rehabil 11:33. https://doi.org/10.1186/1743-0003-11-33

    Article  PubMed  PubMed Central  Google Scholar 

  29. Kamieniarz A, Milert A, Grzybowska-Ganszczyk D, Opara J, Juras G (2021) Tai Chi and Qi Gong therapies as a complementary treatment in Parkinson’s disease—a systematic review. Complement Ther Med 56:102589. https://doi.org/10.1016/j.ctim.2020.102589

    Article  PubMed  Google Scholar 

  30. Wu PL, Lee M, Huang TT (2017) Effectiveness of physical activity on patients with depression and Parkinson’s disease: a systematic review. PLoS ONE 12(7):e0181515. https://doi.org/10.1371/journal.pone.0181515

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Cusso ME, Donald KJ, Khoo TK (2016) The impact of physical activity on non-motor symptoms in Parkinson’s disease: a systematic review. Front Med (Lausanne) 3:35. https://doi.org/10.3389/fmed.2016.00035

    Article  PubMed  Google Scholar 

  32. Da Silva FC, Iop RDR, De Oliveira LC, Boll AM, De Alvarenga JGS, Filho PJBG, De Melo LMAB, Xavier AJ, Da Silva R (2018) Effects of physical exercise programs on cognitive function in Parkinson’s disease patients: a systematic review of randomized controlled trials of the last 10 years. PLoS ONE 13(2):e0193113. https://doi.org/10.1371/journal.pone.0193113

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Šumec R, Filip P, Sheardová K, Bareš M (2015) Psychological benefits of nonpharmacological methods aimed for improving balance in Parkinson’s disease: a systematic review. Behav Neurol 2015:620674. https://doi.org/10.1155/2015/620674

    Article  PubMed  PubMed Central  Google Scholar 

  34. Lee JH, Kim Y, Kim YL (2018) Non-pharmacological therapies for sleep disturbances in people with Parkinson’s disease: a systematic review. J Adv Nurs 74:1741–1751

    Article  Google Scholar 

  35. Murray DK, Sacheli MA, Eng JJ, Stoessl AJ (2014) The effects of exercise on cognition in Parkinson’s disease: a systematic review. Transl Neurodegener 3(1):5. https://doi.org/10.1186/2047-9158-3-5

    Article  PubMed  PubMed Central  Google Scholar 

  36. Hindle JV, Petrelli A, Clare L, Kalbe E (2013) Nonpharmacological enhancement of cognitive function in Parkinson’s disease: a systematic review. Mov Disord 28:1034–1049

    Article  PubMed  Google Scholar 

  37. De Santis KK, Kaplan I (2020) The motor and the non-motor outcomes of Nordic Walking in Parkinson’s disease: a systematic review. J Bodyw Mov Ther 24:4–10

    Article  PubMed  Google Scholar 

  38. Garcia-Agundez A, Folkerts AK, Konrad R, Caserman P, Tregel T, Goosses M, Göbel S, Kalbe E (2019) Recent advances in rehabilitation for Parkinson’s disease with exergames: a systematic review. J Neuroeng Rehabil 16(1):17. https://doi.org/10.1186/s12984-019-0492-1

    Article  PubMed  PubMed Central  Google Scholar 

  39. Dockx K, Bekkers EMJ, Van den Bergh V, Ginis P, Rochester L, Hausdorff JM, Mirelman A, Nieuwboer A (2016) Virtual reality for rehabilitation in Parkinson’s disease. Cochrane Database Syst Rev 12(12):CD010760. https://doi.org/10.1002/14651858.CD010760.pub2

    Article  PubMed  Google Scholar 

  40. Song R, Grabowska W, Park M et al (2017) The impact of Tai Chi and Qigong mind-body exercises on motor and non-motor function and quality of life in Parkinson’s disease: a systematic review and meta-analysis. Parkinsonism Relat Disord 41:3–13

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Goodwin VA, Richards SH, Taylor RS, Taylor AH, Campbell JL (2008) The effectiveness of exercise interventions for people with Parkinson’s disease: a systematic review and meta-analysis. Mov Disord 23:631–640

    Article  PubMed  Google Scholar 

  42. Kalyani HHN, Sullivan K, Moyle G, Brauer S, Jeffrey ER, Roeder L, Berndt S, Kerr G (2019) Effects of dance on gait, cognition, and dual-tasking in Parkinson’s disease: a systematic review and meta-analysis. J Parkinsons Dis 9:335–349

    Article  CAS  PubMed  Google Scholar 

  43. Lamotte G, Rafferty MR, Prodoehl J, Kohrt WM, Comella CL, Simuni T, Corcos DM (2015) Effects of endurance exercise training on the motor and non-motor features of Parkinson’s disease: a review. J Parkinsons Dis 5:21–41

    Article  PubMed  Google Scholar 

  44. Cristini J, Weiss M, De Las Heras B et al (2021) The effects of exercise on sleep quality in persons with Parkinson’s disease: a systematic review with meta-analysis. Sleep Med Rev 55:101384. https://doi.org/10.1016/j.smrv.2020.101384

    Article  PubMed  Google Scholar 

  45. Kwok JJYY, Choi KC, Chan HYL (2016) Effects of mind–body exercises on the physiological and psychosocial well-being of individuals with Parkinson’s disease: a systematic review and meta-analysis. Complement Ther Med 29:121–131

    Article  PubMed  Google Scholar 

  46. Stuckenschneider T, Askew CD, Menêses AL, Baake R, Weber J, Schneider S (2019) The effect of different exercise modes on domain-specific cognitive function in patients suffering from Parkinson’s disease: a systematic review of randomized controlled trials. J Parkinsons Dis 9:73–95

    Article  PubMed  Google Scholar 

  47. Ray S, Agarwal P (2020) Depression and anxiety in Parkinson disease. Clin Geriatr Med 36:93–104

    Article  PubMed  Google Scholar 

  48. Reynolds GO, Otto MW, Ellis TD, Cronin-Golomb A (2016) The therapeutic potential of exercise to improve mood, cognition, and sleep in Parkinson’s disease. Mov Disord 31:23

    Article  PubMed  Google Scholar 

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Funding

The main investigator of this study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES) (Finance Code 001).

Author information

Authors and Affiliations

  1. Department of Physical Education, Santa Catarina State University, R. Pascoal Simone, 358 - Coqueiros, Florianópolis, SC, 88080-350, Brazil

    Jéssica Amaro Moratelli, Alicia Garcia Lima, Kettlyn Hames Alexandre, Danielly Yani Fausto & Adriana Coutinho de Azevedo Guimarães

  2. Brazilian Parkinson’s Disease Rehabilitation Initiative—BpaRkI, Santa Catarina State University, Florianópolis, SC, Brazil

    Jéssica Amaro Moratelli, Aline Nogueira Haas & Adriana Coutinho de Azevedo Guimarães

  3. Department of Science, The Human Movement, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil

    Aline Nogueira Haas

Authors
  1. Jéssica Amaro Moratelli
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  6. Adriana Coutinho de Azevedo Guimarães
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Contributions

JM conceived of the study, initiated the study design, developed the methodology, and commented on initial drafts of the manuscript. AGL and KHA initiated the study design, developed the methodology and contributed to the writing of the manuscript. DF and ANH initiated the study design and developed the methodology. ACdAG initiated the study design and commented on initial drafts of the manuscript. All the authors read and approved the final manuscript.

Corresponding author

Correspondence to Jéssica Amaro Moratelli.

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Moratelli, J.A., Lima, A.G., Alexandre, K.H. et al. Evidence of physical activity interventions on non-motor symptoms of people with Parkinson’s disease: an umbrella review. Sport Sci Health (2024). https://doi.org/10.1007/s11332-024-01197-6

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