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Role of CD3+γδ-T cells in the association of obstructive sleep-disordered breathing and cancer

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References

  1. Palamaner Subash Shantha G, Kumar AA, Cheskin LJ, Pancholy SB (2015) Association between sleep-disordered breathing, obstructive sleep apnea, and cancer incidence: a systematic review and meta-analysis. Sleep Med 16:1289–1294. https://doi.org/10.1016/j.sleep.2015.04.014

    Article  PubMed  Google Scholar 

  2. Sillah A, Watson NF, Schwartz SM, Gozal D, Phipps AI (2018) Sleep apnea and subsequent cancer incidence. Cancer Causes Control 29:987–994. https://doi.org/10.1007/s10552-018-1073-5

    Article  PubMed  PubMed Central  Google Scholar 

  3. Pérez-Warnisher MT, Cabezas E, Troncoso MF, Gómez T, Melchor R, Pinillos EJ, el Hachem A, Gotera C, Rodriguez P, Mahíllo I, González-Mangado N, Peces-Barba G, Seijo LM (2019) Sleep disordered breathing and nocturnal hypoxemia are very prevalent in a lung cancer screening population and may condition lung cancer screening findings: results of the prospective Sleep Apnea In Lung Cancer Screening (SAILS) study. Sleep Med 54:181–186. https://doi.org/10.1016/j.sleep.2018.10.020

    Article  PubMed  Google Scholar 

  4. Koo DL, Lee S, Im JP et al (2016) Obstructive sleep apnea is associated with an increased risk of colorectal neoplasia. Gastrointest Endosc 85:568–573.e1. https://doi.org/10.1016/j.gie.2016.07.061

    Article  PubMed  Google Scholar 

  5. Tanday S (2016) Severe sleep apnoea linked to melanoma risk. Lancet Oncol 17:e229. https://doi.org/10.1016/s1470-2045(16)30161-9

    Article  PubMed  Google Scholar 

  6. Fang HF, Miao NF, Chen CD, Sithole T, Chung MH (2015) Risk of cancer in patients with insomnia, parasomnia, and obstructive sleep apnea: a nationwide nested case-control study. J Cancer 6:1140–1147. https://doi.org/10.7150/jca.12490

    Article  PubMed  PubMed Central  Google Scholar 

  7. Cao J, Feng J, Li L, Chen B (2015) Obstructive sleep apnea promotes cancer development and progression: a concise review. Sleep Breath 19:453–457. https://doi.org/10.1007/s11325-015-1126-x

    Article  PubMed  Google Scholar 

  8. Kendzerska T, Leung RS, Hawker G, Tomlinson G, Gershon AS (2014) Obstructive sleep apnea and the prevalence and incidence of cancer. Cmaj 186:985–992. https://doi.org/10.1503/cmaj.140238

    Article  PubMed  PubMed Central  Google Scholar 

  9. Iwakura Y, Wakita D, Nishikawa H et al (2010) Tumor-infiltrating IL-17-producing γδ T cells support the progression of tumor by promoting angiogenesis. Eur J Immunol 40:1927–1937. https://doi.org/10.1002/eji.200940157

    Article  CAS  PubMed  Google Scholar 

  10. Rei M, Pennington DJ, Silva-Santos B (2015) The emerging protumor role of γδ T lymphocytes: implications for cancer immunotherapy. Cancer Res 75:798–802. https://doi.org/10.1158/0008-5472.CAN-14-3228

    Article  CAS  PubMed  Google Scholar 

  11. Malissen M, Serre K, Silva-Santos B et al (2018) Tumor-associated neutrophils suppress pro-tumoral IL-17+ γδ T cells through induction of oxidative stress. PLoS Biol 16:e2004990. https://doi.org/10.1371/journal.pbio.2004990

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Silva-Santos B, Serre K, Norell H (2012) γδ T cells in cancer. Nat Rev Immunol:23–38. https://doi.org/10.1007/9781441999146_3

  13. Mensurado S, Balkwill FR, Pennington DJ et al (2014) Murine CD27(-) V 6(+) T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages. Proc Natl Acad Sci 111:E3562–E3570. https://doi.org/10.1073/pnas.1403424111

    Article  CAS  PubMed  Google Scholar 

  14. Ma S, Wu Y, Shi L et al (2014) IL-17A produced by T cells promotes tumor growth in hepatocellular carcinoma. Cancer Res 74:1969–1982. https://doi.org/10.1158/0008-5472.can-13-2534

    Article  CAS  PubMed  Google Scholar 

  15. Kolls JK, McAllister F, Pardoll DM et al (2014) Oncogenic Kras activates a hematopoietic-to-epithelial IL-17 signaling axis in preinvasive pancreatic neoplasia. Cancer Cell 25:621–637. https://doi.org/10.1016/j.ccr.2014.03.014

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Staats R, Rodrigues R, Barros A, Bacelar-Nicolau L, Aguiar M, Fernandes D, Moreira S, Simões A, Silva-Santos B, Rodrigues JV, Barbara C, de Almeida AB, Moita LF (2018) Decrease of perforin positive CD3+γδ-T cells in patients with obstructive sleep disordered breathing. Sleep Breath 22:211–221. https://doi.org/10.1007/s11325-017-1602-6

    Article  PubMed  Google Scholar 

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Correspondence to Luís F. Ferreira Moita.

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Staats, R., Rodrigues, R., Barros, A. et al. Role of CD3+γδ-T cells in the association of obstructive sleep-disordered breathing and cancer. Sleep Breath 24, 1673–1674 (2020). https://doi.org/10.1007/s11325-019-01842-2

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  • DOI: https://doi.org/10.1007/s11325-019-01842-2

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