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Evaluating the mandibular condyles of patients with osteoarthritis for bone marrow abnormalities using magnetic resonance T2 mapping

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Abstract

Objectives

This study investigated whether erosion and osteophyte correlates with condyle bone marrow abnormalities (BMA), as detected with quantitative T2 mapping.

Methods

Fifty-six joints (in 44 patients) that demonstrated evidence of bony erosion (ER) or osteophytes (OS) related to disc displacement without reduction were studied with MR images. A control group of 50 joints (in 50 patients) was included. The subjects were divided into five groups; noAR (control), noBMA-ER, BMA-ER, noBMA-OS, and BMA-OS. T2 mapping was performed and the regions of interest were placed over the bone marrow at the top of the condyle. The mean T2 values of the bone marrow of the mandibular condyle were calculated for all mapping images. After assessing age-related changes in T2 values of noAR group using Pearson’s product-moment, differences in median T2 values of five groups were analyzed using Kruskal–Wallis test, and Steel–Dwass test (p < 0.05).

Results

There was no significant correlation between age and T2 value in noAR group. The median T2 values of noBMA-ER and BMA-ER groups were significantly higher than those of noAR, noBMA-OS and BMA-OS groups. Those of noBMA-OS and BMA-OS groups were significantly lower than those of noAR, noBMA-ER and BMA-ER groups. There was no significant difference between noBMA and BMA groups.

Conclusions

It is suggested that erosion and osteophyte of the condyle may correlate with bone marrow abnormalities. T2 mapping could be show slight marrow changes of the arthritic condyle.

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Acknowledgements

This study was supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant number 15K20390.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba, 261-8502, Japan

    Kenichiro Shigeno, Hitoshi Ohata & Takahiko Shibahara

  2. Department of Oral and Maxillofacial Radiology, Tokyo Dental College, 2-1-14 Misakicho, Chiyoda-ku, Tokyo, 101-0061, Japan

    Yoshinori Sasaki & Mika Otonari-Yamamoto

Authors
  1. Kenichiro Shigeno
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Correspondence to Kenichiro Shigeno.

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Conflict of interest

Kenichiro Shigeno, Yoshinori Sasaki, Mika Otonari-Yamamoto, Hitoshi Ohata, and Takahiko Shibahara declare that they have no conflict of interest.

Ethical standards

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study. Additional informed consent was obtained from all patients for which identifying information is included in this article.

Human rights statements and informed consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1964 and later versions. Informed consent was obtained from all patients for being included in the study.

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Shigeno, K., Sasaki, Y., Otonari-Yamamoto, M. et al. Evaluating the mandibular condyles of patients with osteoarthritis for bone marrow abnormalities using magnetic resonance T2 mapping. Oral Radiol 35, 272–279 (2019). https://doi.org/10.1007/s11282-018-0357-5

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  • DOI: https://doi.org/10.1007/s11282-018-0357-5

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