Abstract
D-glucuronic acid is a kind of glucose derivative, which has excellent properties such as anti-oxidation, treatment of liver disease and hyperlipidemia, and has been widely used in medicine, cosmetics, food and other fields. The traditional production methods of D-glucuronic acid mainly include natural extraction and chemical synthesis, which can no longer meet the growing market demand. The production of D-glucuronic acid by biocatalysis has become a promising alternative method because of its high efficiency and environmental friendliness. This review describes different production methods of D-glucuronic acid, including single enzyme catalysis, multi-enzyme cascade, whole cell catalysis and co-culture, as well as the intervention of some special catalysts. In addition, some feasible enzyme engineering strategies are provided, including the application of enzyme immobilized scaffold, enzyme mutation and high-throughput screening, which provide good ideas for the research of D-glucuronic acid biocatalysis.
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Acknowledgements
This work was supported by National Key R and D Program of China (2022YFC3401301), National Natural Science Foundation of China (22078151, 22178169) and Jiangsu Natural Science Fund for Distinguished Young Scholars (BK20220052).
Funding
Funding was provide by National Key Research and Development Program of China (Grant No. 2022YFC3401301), National Natural Science Foundation of China (Grant Nos. 22178169, 22078151), Science Fund for Distinguished Young Scholars of Jiangsu Province (Grant No. BK20220052).
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HH: Investigation, writing—original draft. LJ, JW, JY, WY, WY: Investigation. JY, JW: Supervision. ZW: Supervision, Writing—review and editing. XF: Investigation, Supervision, Writing—review and editing. ZW: Resources, Supervision, Funding acquisition.
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Hu, H., Li, J., Jiang, W. et al. Strategies for the biological synthesis of D-glucuronic acid and its derivatives. World J Microbiol Biotechnol 40, 94 (2024). https://doi.org/10.1007/s11274-024-03900-8
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DOI: https://doi.org/10.1007/s11274-024-03900-8