Abstract
Bionanocomposite is considered an advanced way to bridge the gap between the structural and functional material and achieve the desired properties in the nanocomposite. This present study highlighted the synthesis of fish gelatin-based magnetic nanocomposite (GMNC) using three different concentrations of gelatin (6% w/v, G12% w/v, and 18% w/v) individually, through the in situ coprecipitation method. The effect of gelatin concentration on the structural, functional, magnetic properties, and biocompatibility of the GMNC was studied successfully. This variation reduces the crystallite size from 20.8 to 12.2 nm. GMNC obtained at minimum gelatin concentration (6% w/v) produced well-dispersed sphere-shaped magnetite nanoparticles with an average particle size of 33 nm without aggregation. All three reported superparamagnetic behavior at 293 K. It also noted the highly biocompatible and biodegradable nature of GMNC with a high magnetic response at a low magnetic field. This study reported the perspective of this functionalization method for biomedical applications, as GMNC is a potential carrier material that is easily attached to drug molecules through the free functional residues of gelatin molecules. The present study also performed the in vitro drug release behavior of 5′Fluorouracil-loaded GMNC (GF) at physiological conditions (pH 7.4 and 37 °C). It indicates the prepared GF exhibits a sustained drug-release profile for up to 48 h. Hence, these results strongly supported that the functionalized GMNC would be a potential carrier material for advanced drug delivery applications.
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The datasets generated and analyzed during the current study are available from the corresponding author upon reasonable request.
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Acknowledgements
The authors are greatly thankful to the management of PSG College of Technology, Peelamedu, Coimbatore, for providing the necessary facilities to carry out this research work. A vibrating Sample Magnetometer (VSM) for magnetization work has been carried out at UGC-DAE Consortium for Scientific Research, Kalpakam Node, Kokilamedu.
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VK supervised the experimental assays and contributed to editing the manuscript. MR designed the experimental part and a major contribution to editing the manuscript. VV carried out the experimental part and a major contribution to writing the manuscript. All the authors read and approved the final manuscript.
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Venupriya, V., Krishnaveni, V. & Ramya, M. Fabrication and characterization of fish gelatin-based magnetic nanocomposite for biomedical applications. World J Microbiol Biotechnol 40, 23 (2024). https://doi.org/10.1007/s11274-023-03800-3
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DOI: https://doi.org/10.1007/s11274-023-03800-3