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New variants of human papillomavirus type 18 identified in central Brazil

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Abstract

HPV-18 is the second most prevalent human papillomavirus genotype found in cervical cancer. Nucleotide variations in HPV-18 sequence can interfere with the viral oncogenic potential. However, the knowledge about HPV-18 variants in Brazil is still limited. The present study aims to determine the LCR, E6, and L1 genetic variability of HPV-18 variants found in women co-infected with HIV-1 in Central Brazil. Four HPV-18 samples were identified and had the LCR, E6, and L1 genomic regions sequenced. It was possible to characterize three European variants and one African variant of HPV-18. All of them are new variants, showing nucleotide substitutions not previously reported. Nucleotide variations in binding sites for transcriptional factors were observed. Phylogenetic analysis was also performed, evidencing the three clusters related to the Asian-American, African, and European variants. The characterization of HPV genetic variability is of pivotal importance to the understanding of the viral pathogenicity.

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Acknowledgments

To Kevin P. Karol and Daniel Contaifer, for reviewing this manuscript. This work was supported by Fundação de Apoio à Pesquisa do Distrito Federal (FAP-DF); Fundação de Empreendimentos Científicos e Tecnológicos (FINATEC); Programa Nacional de DST e AIDS, Ministério da Saúde.

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Authors and Affiliations

  1. Pós-Graduação em Biologia Molecular, Instituto de Biologia, Universidade de Brasília ICC Sul, 70919-900, Brasília, DF, Brazil

    Daniela Marreco Cerqueira, Tainá Raiol, Nazle Mendonça Collaço Véras, Natália von Gal Milanezi, Marcelo de Macedo Brígido & Cláudia Renata Fernandes Martins

  2. ANVISA, Ministry of Health, Brasília, Brazil

    Daniela Marreco Cerqueira

  3. Unidade Mista de Saúde da Asa Sul, Brasília, DF, Brazil

    Fádia Aguiar Amaral

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  1. Daniela Marreco Cerqueira
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Correspondence to Daniela Marreco Cerqueira.

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Cerqueira, D.M., Raiol, T., Véras, N.M.C. et al. New variants of human papillomavirus type 18 identified in central Brazil. Virus Genes 37, 282–287 (2008). https://doi.org/10.1007/s11262-008-0263-8

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