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Blood–urea–nitrogen-to-serum–albumin ratio in predicting the value of patients with contrast-induced nephropathy for coronary heart disease

  • Nephrology - Original Paper
  • Published:
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Abstract

Background

The blood–urea–nitrogen (BUN)-to-serum–albumin (ALB) ratio (BAR) has been identified as a novel indicator of both inflammatory and nutritional status, exhibiting a correlation with adverse cardiovascular outcomes. This study aims to investigate the potential predictive value of BAR levels at admission for the development of CIN in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI).

Methods

Retrospective data were collected from patients who were admitted and underwent CAG or PCI between January 2018 and December 2022 at the Cardiac Medical Center of Union Hospital of Fujian Medical University, and the patients were divided into CIN and non-CIN groups. The BAR was computed by dividing the BUN count by the ALB count. Using multiple variable logistic regression, risk variables associated with the development of CIN were found.

Results

A total of 156 patients developed CIN (7.78%). The development of CIN was predicted by a BAR ratio > 4.340 with a sensitivity of 84.0% and a specificity of 70.2%, according to receiver operating characteristic (ROC) analysis. BAR, female gender, diuretic use, and statin medication use were found to be independent predictors of CIN using multifactorial analysis.

Conclusions

When patients are receiving CAG/PCI, BAR is a simple-to-use marker that can be used independently to predict the presence of CIN.

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Data availability

The data that support the findings of this study are available from the corresponding author, Yanjuan Lin, upon reasonable request.

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Funding

This study was funded by the Fiscal Subsidy (2021XH019), Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, and Fujian Provincial Special Reserve Talents Laboratory.

Author information

Author notes

  1. Qiong Pan, Yanchun Peng and Hong Ni are the first co-authors.

Authors and Affiliations

  1. Department of Nursing, Fujian Medical University Union Hospital, Fuzhou, Fujian, China

    Qiong Pan, Yanchun Peng, Hong Ni & Yanjuan Lin

  2. Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China

    Lingyu Lin, Baolin Luo, Xizhen Huang, Liangwan Chen & Yanjuan Lin

Authors
  1. Qiong Pan
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  2. Yanchun Peng
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  3. Hong Ni
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  6. Xizhen Huang
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Contributions

QP, YP, HN, LC, and YL conceived the study. BL and XH performed data collection. QP and LL performed the data analysis. QP wrote the first draft of the manuscript, which was critically reviewed and improved by all authors. LC and YL had the primary responsibility for the final content.

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Correspondence to Liangwan Chen or Yanjuan Lin.

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Pan, Q., Peng, Y., Ni, H. et al. Blood–urea–nitrogen-to-serum–albumin ratio in predicting the value of patients with contrast-induced nephropathy for coronary heart disease. Int Urol Nephrol 56, 2075–2083 (2024). https://doi.org/10.1007/s11255-023-03915-4

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