Abstract
Background and purpose
Acute kidney injury (AKI) is a common complication in patients with sepsis, and early detection and timely treatment are crucial. This article aims to explore the clinical role of microRNA-155 (miR-155) in early diagnosis and prognosis evaluation of septic patients with acute kidney injury.
Methods
We collected the blood samples of septic patients and measured the relative expression of serum miR-155 by RT-qPCR, and drew the receiver operating characteristic (ROC) curves to evaluate its early diagnosis for septic AKI.
Results
The relative expression of miR-155 in the septic AKI was significantly higher than that in the septic non-AKI, and increased with the aggravation of renal function damage. The ROC curve of miR-155 for the diagnosis of septic AKI was 1.91 (95% CI: 1.61–2.19). When the optimal cut-off value of miR-155 expression was 2.37, its sensitivity for diagnosing septic AKI was 91.12% (95% CI: 80.41–95.07%), and its specificity was 84.52% (95% CI: 71.74–89.36%). Furthermore, the severity of kidney injury, SOFA score, APACHE II score and miR-155 were the risk factors affecting the prognosis of septic patients with AKI.
Conclusion
Serum miR-155 can be used as a novel biomarker for the early diagnosis of septic AKI, and also has important clinical value in the prognosis evaluation of septic patients with AKI.
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Data availability
All raw data can be obtained from the corresponding author.
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Acknowledgements
We thank all patients and their families who participated in this study.
Funding
This research was supported by the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China under Grant No. LHDMZ23H050001, the Natural Science Foundation of Ningbo under Grant No. 2022J202, the Zhejiang Provincial Medical and Health Science Foundation of China under Grant No. 2023KY251 and 2022KY1117, the Zhejiang Province Traditional Chinese Medicine Science and Technology Project under Grant No. 2023ZL159.
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HF did the experiments, interpreted of data and wrote the first draft of the manuscript. HF, MS and JHZ participated in conception, design and providing critical revisions. All authors read and approved the final manuscript.
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Fan, H., Sun, M. & Zhu, Jh. Clinical role of serum microRNA-155 in early diagnosis and prognosis of septic patients with acute kidney injury. Int Urol Nephrol 56, 1687–1694 (2024). https://doi.org/10.1007/s11255-023-03855-z
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DOI: https://doi.org/10.1007/s11255-023-03855-z