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Early three-month report of amniotic bladder therapy in patients with interstitial cystitis/bladder pain syndrome

  • Urology - Original Paper
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Abstract

Background

Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by symptomatic frequency and urgency, as well as chronic pelvic pain. Disruption of the urothelial barrier is closely associated with IC/BPS. As amniotic membranes (AM) offer capabilities of wound healing in many other fields of medicine, likewise amniotic bladder therapy (ABT) may offer capability of urothelial healing in IC/BPS.

Methods

Under general anesthesia, 10 consecutive IC/BPS patients received intra-detrusor injections of 100 mg micronized AM (Clarix Flo) diluted in 10 ml 0.9% preservative-free sodium chloride. Clinical evaluation and questionnaires (Interstitial Cystitis Symptom Index (ICSI), Interstitial Cystitis Problem Index (ICPI), Bladder Pain/ Interstitial Cystitis Symptom Score (BPIC-SS), Overactive Bladder Assessment Tool, and SF-12 Health Survey) were repeated at pre-op and 2, 4, 8 and 12 weeks post-op.

Results

Ten females (47.4 ± 14.4 years) who had recalcitrant IC/BPS for 7.8 years (5.2–12.1 years) received injection of micronized AM uneventful in all cases. After treatment, voiding symptoms and bladder pain significantly improved from pre-injection to 3 months. BPIC-SS significantly decreased from 37.4 ± 0.70 at baseline to 12.2 ± 2.90 at 3 months (p < 0.001). This corresponded to a significant improvement in their overall physical and mental quality of life. No adverse events occurred related to micronized AM injections, such as UTIs or acute urinary retention.

Conclusion

ABT could be an innovative treatment option for IC/BPS patients in terms of improving clinical symptoms based on preliminary outcomes at 3 months. Further studies are warranted to confirm the usefulness of ABT in patients with IC/BPS and to determine the duration of the effect.

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Data availability

The data that support the findings of this study are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Wayne State University School of Medicine, Detroit, MI, USA

    Raghav Madan, Codrut Radoiu, Aron Liaw & Steven Lucas

  2. John D. Dingell VA Medical Center, 4646 John R Street, Detroit, MI, 48201, USA

    Aron Liaw, Steven Lucas, Alaa Hamada & Nivedita Dhar

  3. Detroit Medical Center, Detroit, MI, USA

    Nivedita Dhar

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  1. Raghav Madan
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  2. Codrut Radoiu
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  3. Aron Liaw
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Correspondence to Nivedita Dhar.

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This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the local institutional review board.

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Informed consent was obtained from participants included in the study.

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Madan, R., Radoiu, C., Liaw, A. et al. Early three-month report of amniotic bladder therapy in patients with interstitial cystitis/bladder pain syndrome. Int Urol Nephrol 55, 1937–1942 (2023). https://doi.org/10.1007/s11255-023-03652-8

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  • DOI: https://doi.org/10.1007/s11255-023-03652-8

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