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Association of fetuin-A levels and left ventricular diastolic dysfunction in patients on haemodialysis

  • Nephrology - Original Paper
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Abstract

Objective

To identify the relationship between serum fetuin-A levels and left ventricular diastolic dysfunction (LVDD) among maintenance haemodialysis patients.

Methods

In a cross-sectional study, 75 dialysis patients with end-stage renal disease (ESRD) were recruited, and fetuin-A levels were detected using an enzyme-linked immunosorbent assay (ELISA). Echocardiography measurements were recorded according to the recommendations of the American Society of Echocardiography. The ratio of early diastolic transmitral inflow velocity (E) to early diastolic annular velocity (E′) was measured using tissue Doppler imaging and E/E′ > 15 was defined as diastolic dysfunction. The association of serum fetuin-A concentrations with echocardiographic parameters was analysed by calculating the bivariate linear correlation. A binary logistic regression analysis was conducted to determine the variables associated with LVDD.

Results

Compared to patients without diastolic dysfunction, patients with diastolic dysfunction were older, a higher percentage had a history of coronary artery disease, and presented with a high systolic pressure, high parathyroid hormone level, high N-terminal pro-brain natriuretic peptide (NT-proBNP) level, high LV mass index, high left atrium diameter, and low serum creatinine and fetuin-A levels. Serum fetuin-A levels showed a negative correlation with E/E′ (r = − 0.299, P = 0.009). Fetuin-A levels were considered an independent predictor of diastolic dysfunction.

Conclusion

A decrease in the serum fetuin-A level is associated with an increased risk of LVDD in patients on haemodialysis.

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Authors and Affiliations

  1. Department of Nephrology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China

    Yangang Gan & Jinhong Feng

  2. Department of Radiology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, China

    Mingming Zhao

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  1. Yangang Gan
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  2. Mingming Zhao
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Correspondence to Jinhong Feng.

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All the procedures performed in this study were conducted in accordance with the ethical standards of the institutional and international research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Informed consent was obtained from all participants included in the study.

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Gan, Y., Zhao, M. & Feng, J. Association of fetuin-A levels and left ventricular diastolic dysfunction in patients on haemodialysis. Int Urol Nephrol 53, 1689–1694 (2021). https://doi.org/10.1007/s11255-021-02796-9

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  • DOI: https://doi.org/10.1007/s11255-021-02796-9

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