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Relation of serum spondin-2 levels with cardiac morphology and inflammatory parameters in hemodialysis patients

  • Nephrology - Original Paper
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Abstract

Purpose

Cardiovascular diseases are the leading causes of mortality in chronic kidney disease. Spondin-2 (SP-2), an intrinsic cardio-protective factor, prevents maladaptive remodeling. We aimed to determine the relation between serum SP-2 levels and cardiac morphology along with inflammatory parameters in hemodialysis (HD) patients.

Method

The study comprised a total of 95 patients (61 females) receiving HD treatment three times a week for at least 6 months, and a control group consisting of age and gender matched 62 subjects (34 females). SP-2 levels were determined by ELISA. Echocardiography, 24-h ambulatory blood pressure monitoring, and carotid artery intima-media thickness (CIMT) measurement were performed in all subjects. The relation of serum SP-2 levels with CIMT, echocardiographic parameters, CRP, and absolute neutrophil-to-lymphocyte count ratio (NLR) was evaluated by correlation analysis.

Results

SP-2 levels were found to be significantly higher in the HD group than the control group (16.660 [8.719–20.938] vs. 3.988 [2.702–8.042] ng/L; P < 0.001). CIMT, CRP, and NLR were also higher in HD group (P < 0.005, P < 0.001, and P < 0.001, respectively). Significantly positive correlation was found between SP-2 and left ventricular mass, left ventricular mass index, CRP, and NLR, but no correlation was determined between SP-2 and CIMT. SP-2 was not statistically significant variable for the determination of LVH in univariate logistic regression analysis [Wald = 2.375; OR (95% CI) = 1.000 (0.999–1.000), P = 0.123].

Conclusion

Serum SP-2 levels were higher in HD patients compared to the population with normal renal functions. The results suggest that SP-2, an uremic toxin, might be effective over a complex pathway in the inflammatory process and in the pathogenesis of cardiovascular diseases of patients under HD treatment.

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Authors and Affiliations

  1. Department of Nephrology, School of Medicine, Hitit University, 19100, Corum, Turkey

    Ibrahim Dogan & Baris Eser

  2. Department of Cardiology, School of Medicine, Hitit University, Corum, Turkey

    Mucahit Yetim, Tolga Dogan, Macit Kalcik & Yusuf Karavelioglu

  3. Department of Biochemistry, School of Medicine, Hitit University, Corum, Turkey

    Huseyin Kayadibi

  4. Medical Biology, School of Medicine, Cukurova University, Adana, Turkey

    Mehmet Bertan Yilmaz

Authors
  1. Ibrahim Dogan
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  2. Mucahit Yetim
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  3. Tolga Dogan
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  4. Huseyin Kayadibi
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  5. Mehmet Bertan Yilmaz
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  6. Baris Eser
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  7. Macit Kalcik
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  8. Yusuf Karavelioglu
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Correspondence to Ibrahim Dogan.

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Authors declare no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Erciyes University institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individuals included in this study.

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Dogan, I., Yetim, M., Dogan, T. et al. Relation of serum spondin-2 levels with cardiac morphology and inflammatory parameters in hemodialysis patients. Int Urol Nephrol 50, 2091–2097 (2018). https://doi.org/10.1007/s11255-018-1996-5

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  • DOI: https://doi.org/10.1007/s11255-018-1996-5

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