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Clinical trial of the effects of coenzyme Q10 supplementation on glycemic control and markers of lipid profiles in diabetic hemodialysis patients

  • Nephrology - Original Paper
  • Published:
International Urology and Nephrology Aims and scope Submit manuscript

30 April 2020 Concerns have been raised about integrity of the clinical trial reported in 10.1007/s11255-018-1973-z. There is an ongoing investigation by the Iranian National Committee for Ethics in Biomedical Researches. Further editorial action will be taken as appropriate once the investigation into the concerns is complete and all parties have been given an opportunity to respond in full.

Abstract

Purpose

The current study was conducted to determine the effects of coenzyme Q10 (CoQ10) supplementation on glycemic control and markers of lipid profiles risk in diabetic hemodialysis (HD) patients.

Methods

This randomized, double blind, placebo-controlled clinical trial was performed among 60 diabetic HD patients. Subjects were randomly allocated into two groups to take either 120 mg/day of CoQ10 supplements or placebo (n = 30 each group) for 12 weeks.

Results

After 12 weeks of intervention, CoQ10 supplementation, compared with the placebo, resulted in a significant decrease in serum insulin concentrations (− 2.5 ± 4.0 vs. + 2.8 ± 5.3 µIU/mL, P < 0.001), homeostasis model of assessment-estimated insulin resistance (− 0.9 ± 2.1 vs. + 1.2 ± 3.0, P = 0.002), and significant increase in the quantitative insulin sensitivity check index (+ 0.009 ± 0.01 vs. − 0.02 ± 0.05, P = 0.003). In addition, a trend toward a greater decrease in serum triglycerides (− 5 ± 53 vs. + 17 ± 44, P = 0.078) and VLDL-cholesterol levels (− 0.9 ± 10 vs. + 3 ± 9,P = 0.078) was observed in the CoQ10 group compared to the placebo group. We did not observe any significant effect of CoQ10 supplementation on fasting glucose, HbA1c and other lipid profiles compared with the placebo.

Conclusions

Overall, our study supported that CoQ10 supplementation to diabetic HD patients for 12 weeks had beneficial effects on markers of insulin metabolism, but did not affect fasting glucose, HbA1c, and lipid profiles.Clinical registration http://www.irct.ir: IRCT2016081811763N30.

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  • 30 April 2020

    Concerns have been raised about integrity of the clinical trial reported in 10.1007/s11255-018-1973-z. There is an ongoing investigation by the Iranian National Committee for Ethics in Biomedical Researches. Further editorial action will be taken as appropriate once the investigation into the concerns is complete and all parties have been given an opportunity to respond in full.

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Acknowledgements

The present study was supported by a grant from the Vice-chancellor for Research, IUMS, and Iran.

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Authors and Affiliations

  1. Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

    Melika Fallah & Gholamreza Askari

  2. Department of Internal Medicine, Kashan University of Medical Sciences, Kashan, Iran

    Alireza Soleimani

  3. Isfahan Endocrine and Metabolism Research Center, Isfahan, Iran

    Awat Feizi

  4. Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran

    Awat Feizi

  5. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran

    Zatollah Asemi

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  1. Melika Fallah
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Contributions

MF, GA and ZA contributed in conception, data collection and manuscript drafting. AS and AF contributed in conception, data collection and manuscript drafting. All authors read and approved the final version of the paper.

Corresponding author

Correspondence to Gholamreza Askari.

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Fallah, M., Askari, G., Soleimani, A. et al. Clinical trial of the effects of coenzyme Q10 supplementation on glycemic control and markers of lipid profiles in diabetic hemodialysis patients. Int Urol Nephrol 50, 2073–2079 (2018). https://doi.org/10.1007/s11255-018-1973-z

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