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Combination of sacral nerve and tibial nerve stimulation for treatment of bladder overactivity in pigs

  • Urology - Original Paper
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Abstract

Purpose

Sacral nerve and tibial nerve stimulation have been singly used to treat overactive bladder (OAB). This study evaluated the effects of both combined stimulation on treating bladder overactivity in pigs and explored a novel treatment modality for OAB.

Methods

An implant-driven stimulator of the S3 spinal nerve was implanted in 5 pigs. The contralateral tibial nerve was stimulated by an external stimulator. Multiple cystometrograms were performed to determine the effects of single nerve stimulation and combination sacral nerve stimulation (SNS) and tibial nerve stimulation (TNS) on the micturition reflex by infusing normal saline (NS) or acetic acid (AA).

Results

AA-induced bladder overactivity significantly reduced bladder capacity (BC) to 16.3 ± 2.2% of the NS control level (389.4 ± 27.68 ml; P < 0.01). When given a single stimulation, both SNS and TNS significantly increased the BC to 39.2 ± 1.6% and 34.9 ± 5.0% of the NS control level (P < 0.01), respectively. Combined SNS and TNS significantly increased the BC to 50.2 ± 5.2% of the NS control level (P < 0.01) and induced a superior inhibitory effect than SNS or TNS alone (P < 0.05).

Conclusions

Combination SNS and TNS induced a superior inhibitory effect on bladder overactivity in pigs compared to single stimulation and thus could be a novel treatment modality for OAB.

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Acknowledgements

This study was funded by the National Natural Science Foundation of China (81570688) and Beijing Natural Science Foundation (7153179). The authors also would like to thank Pins Medical (Beijing, China) for providing products and technical support.

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Authors and Affiliations

  1. Rehabilitation School of Capital Medical University, Beijing, China

    Xing Li, Limin Liao, Guoqing Chen, Zhaoxia Wang & Han Deng

  2. Department of Urology, China Rehabilitation Research Center, Beijing, China

    Xing Li, Limin Liao, Guoqing Chen, Zhaoxia Wang & Han Deng

  3. Beijing Key Laboratory of Neural Injury and Rehabilitation, Beijing, China

    Xing Li, Limin Liao, Guoqing Chen, Zhaoxia Wang & Han Deng

  4. Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, China

    Xing Li, Limin Liao, Guoqing Chen, Zhaoxia Wang & Han Deng

Authors
  1. Xing Li
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  2. Limin Liao
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  3. Guoqing Chen
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  4. Zhaoxia Wang
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  5. Han Deng
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Corresponding author

Correspondence to Limin Liao.

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The authors declare that they have no conflict of interest.

Ethical approval

All applicable International, National, and/or Institutional Guidelines for the care and use of animals were followed.

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Li, X., Liao, L., Chen, G. et al. Combination of sacral nerve and tibial nerve stimulation for treatment of bladder overactivity in pigs. Int Urol Nephrol 49, 1139–1145 (2017). https://doi.org/10.1007/s11255-017-1587-x

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  • DOI: https://doi.org/10.1007/s11255-017-1587-x

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