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Correlation between cathepsin D serum concentration and carotid intima-media thickness in hemodialysis patients

  • Nephrology – Original Paper
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Abstract

Aim

Cardiovascular (CV) disease is the leading cause of death in hemodialysis (HD) patients, and approximately half of mortalities in HD patients are attributed to CV disease. Atherosclerosis is the most frequent cause of CV complications in patients with end-stage renal disease (ESRD). Based on recent studies, cathepsin D has been suggested as a potential marker of atherosclerosis, and we hypothesized that there is an association between serum concentration of cathepsin D and carotid intima-media thickness (CIMT) in hemodialysis patients.

Methods

Thirty-one hemodialysis patients (18 men and 13 women) were enrolled in this study. Serum levels of soluble cathepsin D were measured with an enzyme-linked immunosorbant assay (ELISA) kit. CIMT was determined in each patient.

Results

The data showed that there was a positive significant correlation between serum concentration of cathepsin D and CIMT by using Pearson correlation (P value <0.05).

Conclusion

Based on the results of this study, cathepsin D could be suggested to have a role in the development of atherosclerotic plaques.

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Acknowledgments

This study is part of a research thesis for a Pharm.D. degree at Mashhad University of Medical Sciences. The authors are thankful for the funding of this study by the Research Council of Mashhad University of Medical Sciences and to Dr Paul A. Jowsey from Newcastle University, UK for his kind assistance in linguistic revision of this manuscript.

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Authors and Affiliations

  1. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Seyed Adel Moallem

  2. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Seyed Adel Moallem, Sepideh Eliasi & Jamal Shamsara

  3. Nephrology Ward, Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

    Fatemeh Nazemian

  4. Radiology Department, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

    Seyed Ali Alamdaran

  5. Pharmaceutical Research Center, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, Iran

    Amir Hooshang Mohammadpour

Authors
  1. Seyed Adel Moallem
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  2. Fatemeh Nazemian
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  3. Sepideh Eliasi
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  4. Seyed Ali Alamdaran
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  5. Jamal Shamsara
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  6. Amir Hooshang Mohammadpour
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Corresponding author

Correspondence to Amir Hooshang Mohammadpour.

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Moallem, S.A., Nazemian, F., Eliasi, S. et al. Correlation between cathepsin D serum concentration and carotid intima-media thickness in hemodialysis patients. Int Urol Nephrol 43, 841–848 (2011). https://doi.org/10.1007/s11255-010-9729-4

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  • DOI: https://doi.org/10.1007/s11255-010-9729-4

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