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The efficacy and performance impact of Fostera PRRS in a Vietnamese commercial pig farm naturally challenged by a highly pathogenic PRRS virus

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Abstract

Highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) is characterized by high fever, respiratory distress, and high mortality in pigs of all ages and has severely affected the Vietnam pork industry in recent years. The study was conducted to compare the efficacy, safety, and overall performance of a modified live PRRSV-2 vaccine (Fostera PRRS) to an existing PRRSV modified live vaccine on a farm with a recent history of HP-PRRSV-associated respiratory diseases. A total of 351 pigs were randomly allocated to three treatment groups: (i) vaccinated with Fostera PRRS at 1 day of age (n = 118), (ii) vaccinated with Fostera PRRS (n = 118) at 21 days of age, and (iii) vaccinated with Amervac PRRS (n = 115) at 21 days of age. The Fostera PRRS vaccinated pigs had milder clinical symptoms, lower levels of HP-PRRSV viremia, fewer pathological changes in the lung, and higher body weight gain at the end of the study compared with the Amervac PRRS group. Vaccination of pigs with Fostera PRRS at 1 day of age also significantly reduced viral loads in their blood (P < 0.05) and induced higher anti-PRRSV antibody titers (P < 0.01) compared with pigs vaccinated with Amervac PRRS at 21 days of age. Fostera PRRS vaccination at 1 day of age can be useful in protecting young piglets from early HP-PRRSV infection because the immunized pigs were marketed 20 days earlier than their peers immunized at 21-day old as they reached the target market weight earlier in this study.

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Acknowledgments

This research was supported by the Zoetis through contract research funds (Study Protocol # 17INTORPORKBIO07). The authors would like to thank Zoetis Vietnamese personnel and personnel who are working on a swine farm and supported the study. The study was also carried out over 6 months long by a few students of the Faculty of Animal Science and Veterinary Medicine, Nong Lam University, Thu Duc district, Hochiminh City, Vietnam.

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Authors and Affiliations

  1. Faculty of Animal Science and Veterinary Medicine, Nong Lam University, Thu Duc district, Hochiminh City, Vietnam

    Duy Tien Do, Toan Tat Nguyen, Mai Ha Phuong Nguyen, Hien Thanh Le, Nam Thi Thu Nguyen & Ninh Thi Phuoc Nguyen

  2. Zoetis, Parsippany, NJ, USA

    Nguyen Tien Hoang Nguyen & Choew Kong Mah

  3. College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea

    Chanhee Chae

Authors
  1. Duy Tien Do
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  2. Toan Tat Nguyen
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  3. Nguyen Tien Hoang Nguyen
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  4. Mai Ha Phuong Nguyen
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  5. Hien Thanh Le
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  6. Nam Thi Thu Nguyen
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  7. Ninh Thi Phuoc Nguyen
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  8. Chanhee Chae
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  9. Choew Kong Mah
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Contributions

Conceived or designed study: Duy Tien Do, Toan Tat Nguyen, Chanhee Chae, ChoewKong Mah

Performed research: Nam Thi Thu Nguyen, Ninh Thi Phuoc Nguyen, Hien Thanh Le, Mai Ha Phuong Nguyen

Analyzed data: Mai Ha Phuong Nguyen, Hien Thanh Le, Duy Tien Do

Contributed new methods or models: Duy Tien Do, Chanhee Chae

Wrote the paper: Duy Tien Do, Chanhee Chae, ChoewKong Mah

Corresponding author

Correspondence to Duy Tien Do.

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Statement of animal rights

All methods and animal studies were conducted under the approval of Nonglam University Animal Ethics Committee (AEC), Nonglam University, Vietnam (NLU-190702).

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The authors declare that they have no conflict of interest.

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Do, D.T., Nguyen, T.T., Nguyen, N.T.H. et al. The efficacy and performance impact of Fostera PRRS in a Vietnamese commercial pig farm naturally challenged by a highly pathogenic PRRS virus. Trop Anim Health Prod 52, 1725–1732 (2020). https://doi.org/10.1007/s11250-019-02177-6

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