References
Khatri P, Conaway MR, Johnston KC; Acute Stroke Accurate Prediction Study (ASAP) Investigators (2012) Ninety-day outcome rates of a prospective cohort of consecutive patients with mild ischemic stroke. Stroke 43:560–562
Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, Stroke Thrombolysis Trialists’ Collaborative Group et al (2014) Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 384(9958):1929–1935
Wardlaw JM, Murray V, Berge E, del Zoppo GJ (2014) Thrombolysis for acute ischaemic stroke. Cochrane Database Syst Rev (7):CD000213
Khatri P, Kleindorfer DO, Devlin T, Sawyer RN Jr, Starr M, Mejilla J, Investigators PRISMS et al (2018) Effect of alteplase vs aspirin on functional outcome for patients with acute ischemic stroke and minor nondisabling neurologic deficits: the PRISMS Randomized Clinical Trial. JAMA 320:156–166
Guidetti D (2010) “MINOR” study, thrombolysis in minor stroke; EudraCT N°: 2013-001617-32, granted by Ministero della Salute, Italy, bando di ricerca 2010, RF 2010-2311584)
Italian Stroke Organization Guidelines (2016) http://www.iso-stroke.it
You S, Saxena A, Wang X, Tan W, Han Q, Cao Y, Liu CF (2018) Efficacy and safety of intravenous recombinant tissue plasminogen activator in mild ischaemic stroke: a meta-analysis. Stroke Vasc Neurol 3:22–27
Ferrari J, Krebs S, Sykora M (2019) Intravenous thrombolysis and mechanical thrombectomy in patients with minor or rapidly improving neurological deficits. Curr Opin Neurol 32(1):13–18
Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, American Heart Association Stroke Council et al (2018) 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 49:e46–e110
TEMPO 2. University of Calgary: Clinicaltrials.gov. https://clinicaltrials.gov/ct2/show/NCT02398656?term=tempo-2draw=2&rank=1
Griessenauer CJ, Medin C, Maingard J, Chandra RV, Ng W, Brooks DM et al (2018) Endovascular mechanical thrombectomy in large-vessel occlusion ischemic stroke presenting with Low National Institutes of Health Stroke Scale: systematic review and meta-analysis. World Neurosurg 110:263–269
Levine SR, Weingast SZ, Weedon J, Stefanov DG, Katz P, Hurley D et al (2018) To treat or not to treat? Stroke 49(8):1933–1938
Chacon-Portillo MA, Llinas RH, Marsh EB (2018) Cerebral microbleeds shouldn’t dictate treatment of acute stroke: a retrospective cohort study evaluating risk of intracerebral Hemorrhage. BMC Neurol 18(1):33
Acknowledgements
The authors thank Dr. S. Ferro (Health Agency of Emilia-Romagna - Italy) for his support to the “MINOR” trial and Mrs. Barbara Wade for her linguistic advice.
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Rota, E., Morelli, N., Immovilli, P. et al. “Minor” stroke: not a minor, still open question. J Thromb Thrombolysis 49, 132–135 (2020). https://doi.org/10.1007/s11239-019-02001-w
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DOI: https://doi.org/10.1007/s11239-019-02001-w