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Off-pump technique and replacement therapy for coronary artery bypass surgery in a patient with hemophilia B

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Abstract

Antithrombotic treatment and perioperative management in patients with hemophilia remains a challenge. As life expectancy in these patients is increasing, a concern about cardiovascular diseases is emerging. Herein we present the case of a 68 year-old patient with mild hemophilia B and multivessel coronary disease who underwent coronary artery bypass grafting (CABG) surgery. Off-pump surgery with continuous infusion FIX treatment was performed successfully with stable factor IX levels, and no bleeding or thrombotic complications. There is a paucity of cases reported regarding management of CABG in this population. To our knowledge, this is the first patient with mild hemophilia B that underwent CABG surgery with off-pump technique, that seems to be a secure and effective procedure.

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Authors and Affiliations

  1. Hemophilia and Thrombosis Unit, Department of Hematology, Vall d’Hebron University Hospital, Barcelona, Spain

    M. Fernández-Caballero, M. F. Martinez & A. Santamaría

  2. Department of Cardiology, Vall d’Hebron University Hospital, Barcelona, Spain

    G. Oristrell

  3. Department of Cardiac Surgery, Vall d’Hebron University Hospital, Barcelona, Spain

    N. Palmer

Authors
  1. M. Fernández-Caballero
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  2. M. F. Martinez
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  3. G. Oristrell
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  4. N. Palmer
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  5. A. Santamaría
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Correspondence to M. Fernández-Caballero.

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Conflic of interest

MFernández-Caballero has received financial support from Bayer. MF Martínez has received financial support from Bayer and Daiichi Sankyo for various scientific activities. A Santamaría has participated in Advisory Boards for Octapharma, Novo Nordisk, Bayer, Pfizer, BMS, Sobi, Shire, Roche, Sanofi, LEO Pharma, Rovi, Daiichi Sankyo, Werfen and Ferrer. A Santamaría has received travel support from Octapharma, Novo Nordisk, Bayer, Pfizer, BMS, Sobi, Bayer, Shire, Roche, Sanofi, LEO Pharma, Rovi, Daiichi Sankyo and Werfen. A Santamaría has received Research Support: Rovi, Shire, Bayer, LEO Pharma, BMS, Pfizer. A Santamaría has done consultancy for Bayer, Pfizer, MS and Rovi. A Santamaría has received honoraria per conferences from Octapharma, Novo Nordisk, Bayer, Pfizer, BMS, Sobi, Shire, Sanofi, LEO Pharma, Rovi, Daiichi Sankyo, Werfen and Ferrer. G. Oristrell declares that he has no conflict of interest. N. Palmer declares that he has no conflict of interest. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

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Fernández-Caballero, M., Martinez, M., Oristrell, G. et al. Off-pump technique and replacement therapy for coronary artery bypass surgery in a patient with hemophilia B. J Thromb Thrombolysis 48, 299–302 (2019). https://doi.org/10.1007/s11239-019-01888-9

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  • DOI: https://doi.org/10.1007/s11239-019-01888-9

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