Abstract
Continuous flow left ventricular assist devices (CF-LVAD) require therapeutic anticoagulation which is often interrupted for procedures or bleeding. Prior to the availability of four factor prothrombin complex concentrate (4F-PCC) in the United States, warfarin was held and its effects reversed by vitamin K or fresh frozen plasma. We evaluated the use of 4F-PCC for temporary warfarin reversal in patients with CF-LVADs and assessed outcomes. This analysis is a retrospective study of CF-LVAD patients who received 4F-PCC for warfarin reversal in the setting of bleeding or need for urgent or elective procedures. Primary outcome assessments included feasibility of administration in elective versus emergent situations, safety measured as incidence of thrombotic events, and change in INR after administration. In total, 37 CF-LVAD patients received 49 4F-PCC administrations. The average 4F-PCC dose was 1842 units (range 518–4292 units), or 22 units/kg (range 5.8–58 units/kg). 4F-PCC significantly decreased the mean INR from 2.9 to 1.7 (p < 0.0001) in 47 of 49 administrations; two patients did not have post infusion INR testing. No cases of new confirmed or suspected pump thrombosis, stroke, venous thromboembolism, arterial thrombosis, or myocardial infarction were observed within 30 days of administration of 4F-PCC. 4F-PCC administration for temporary warfarin reversal was demonstrated to be feasible, effective, and, safe in CF-LVAD patients and judged to be 96% effective in patients for whom data were available. We observed no thrombotic events attributed to use of 4F-PCC.
Similar content being viewed by others
Abbreviations
- CF-LVAD:
-
Continuous flow left ventricular assist devices
- IV:
-
Intravenous
- FFP:
-
Fresh frozen plasma
- FDA:
-
Food and Drug Administration
- 4F-PCC, KCentra®:
-
Four-factor prothrombin complex concentrate
- INR:
-
International normalized ratio
- LDH:
-
Lactate dehydrogenase
- IQR:
-
Interquartile range
- PICC:
-
Peripherally inserted central catheter
References
Sarode R, Milling TJ Jr, Refaai MA, Mangione A, Schneider A, Durn BL, Goldstein JN (2013) Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study. Circulation 128:1234–1243. https://doi.org/10.1161/CIRCULATIONAHA.113.002283
Kcentra Prescribing Information CSL, Behring LLC. Kankakee, IL. March 2014
Kirklin JK, Naftel DC, Pagani FD, Kormos RL, Myers S, Acker MA, Rogers J, Slaughter MS, Stevenson LW (2015) Pump thrombosis in the Thoratec HeartMate II device: an update analysis of the INTERMACS Registry. J Heart Lung Transplant 34:1515–1526. https://doi.org/10.1016/j.healun.2015.10.024
Sorensen B, Spahn DR, Innerhofer P, Spannagl M, Rossaint R (2011) Clinical review: Prothrombin complex concentrates–evaluation of safety and thrombogenicity. Crit Care 15:201. https://doi.org/10.1186/cc9311 Epub 2011 Jan 12.
Cowger JA, Romano MA, Shah P, Shah N, Mehta V, Haft JW, Aaronson KD, Pagani FD (2014) Hemolysis: a harbinger of adverse outcome after left ventricular assist device implant. J Heart Lung Transplant 33:35–43. https://doi.org/10.1016/j.healun.2013.08.021
Kar R, Abel E, Burcham P, Firstenberg MS (2013) Prothrombin complex concentrate for warfarin-induced bleeding in a patient with a mechanical aortic valve. Interact Cardiovasc Thorac Surg 17(2):421–422. https://doi.org/10.1093/icvts/ivt207 Epub 2013 May 10.
Nashett RM, Sylvester K, Connors JM (2016) Lowering INR using four factor prothrombin complex concentrate for procedures in patients with ventricular assist devices: a case series. J Hematol Ther 1(1):1–4. https://doi.org/10.14312/2397-8694.2016-1
Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD, Wallentin L, RE-LY Steering Committee and Investigators (2009) Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361(12):1139–1151. https://doi.org/10.1056/NEJMoa0905561. Epub 2009 Aug 30
Andreas M, Roxana M, Wieselthaler G, Wolzt M, Riebandt J, Haberl T, Angleitner P, Schlöglhofer T, Wiedemann D, Schima H, Laufer G, Zimpfer D (2017) Increased thromboembolic events with dabigatran compared with vitamin K antagonism in left ventricular assist device patients. Circulation 10:e003709. https://doi.org/10.1161/CIRCHEARTFAILURE.116.003709
Acknowledgements
Rebecca Nashett PharmD, Hisham Badreldin PharmD.
Funding
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
Jessica Rimsans, Amy Levesque, Erin Lyons, Michael Givertz, and Garrick Stewart declares that they have no conflict of interest. Mandeep Mehra is a consult for Abbott, Medtronic Johnson & Johnson, NuPulseCV, Mesoblast, Stealth BioTherapeutics, and Portola. Jean M. Connors has received honoraria from Bristol-Meyer Squibb, Boehringer Ingleheim, and research funding to the institution from CSL Behring.
Ethical approval
This article does not contain any studies with human participants performed by any of the authors.
Informed consent
Informed consent was not required to be obtained from all individual participants included in the study.
Rights and permissions
About this article
Cite this article
Rimsans, J., Levesque, A., Lyons, E. et al. Four factor prothrombin complex concentrate for warfarin reversal in patients with left ventricular assist devices. J Thromb Thrombolysis 46, 180–185 (2018). https://doi.org/10.1007/s11239-018-1680-8
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11239-018-1680-8