Abstract
Life expectancy in the hemophilia people is similar to the non–haemophilics and age-related cardiovascular disorders to become more prevalent, but cardiac surgery is considered a very high risk for these patients. In this article we report the successful cardiac double bypass internal mammary artery—coronary artery in a patient with severe hemophilia A. (FVIII<1%; missense mutation: exon 16, c.5508 G>A (domain A3), p.Trp1817Stop). Continuous infusion of rFVIII B-domain deleted was used to control haemostasis during surgery and in post-operative period. There was no bleeding complications and the patient did not need to receive transfusion of red blood cells or platelets.
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References
Tang M, Wierup P, Terp K, Ingerslev J, Sørensen B (2009) Cardiac surgery in patients with haemophilia. Haemophilia 15:101–107
Eren A, Friedl R, Hannekum A, Gulbins H (2006) Cardiac surgery in a patient with haemophilia A. Thorac Cardiov Surg 54:212–214
Pesaro AE, Gaz MV, Karbstein R et al (2009) Coronary artery bypass surgery, angioplasty and long term anti-platelet treatment in a type B hemophilia patient. Clinics 64(8):822
Hvas AM, Sorensen HT, Norengaard L, Christiansen K, Ingerslev J, Sørensen B (2007) Tranexamic acid combined with recombinant factor VIII increases clot resistance to accelerated fibrinolysis in severe hemophilia A. J Thromb Haemost 5:2408–2414
World Federation Haemophilia (WFH) (2005) Guidelines for the management of haemophilia
Stieltjes N, Altisent C, Auerswald G, Negrier C, Pouzol P, Reynaud J, Roussel G, Savidge F, Villar A, Schulman S (2004) Continuous infusion of B-domain deleted recombinant factor VIII (ReFacto) in patients with haemophilia A undergoing surgery: clinical experience. Haemophilia 10:452–458
Sharathkumar A, Lillicrap D, Blanchette VS, Kern M, Leggo J, Stain AM, Brooker L, Carcao MD (2003) Intensive exposure to factor VIII is a risk factor for inhibitor development in mild hemophilia A. J Thromb Haemost 1:1228–1236
Gouw SC, Van der Bom JG, Van der Berg HM, Zewald RA, Ploos Van Amstel JK, Mauser-Bunschoten EP (2011) Influence of the type F8 mutation on inhibitor development in a single centre cohort of haemophilia A patients. Haemophilia 17:275–281
Kim Ms, Kilgore PE, Kang JS, Kim SY, Lee DY, Kim JS, Hwang PH (2008) Transient acquired hemophilia associated with Mycoplasma pneumonia Pneumoniae. J Korean Med Sci 23:138–141
Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, Colwell CW (2008) American college chest physicians. Prevention of thromboembolism: American college of chest physicians: evidence-based clinical practice guidelines (8th Edition). Chest 133:381–453
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Barillari, G., Pasca, S., Erice, F. et al. Successful double bypass in a patient with severe hemophilia A: a case report. J Thromb Thrombolysis 33, 193–196 (2012). https://doi.org/10.1007/s11239-011-0664-8
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DOI: https://doi.org/10.1007/s11239-011-0664-8