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Does anti-tnf therapy cause any change in platelet activation in ankylosing spondylitis patients?

A comparative study

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Abstract

Recently, it has been reported that ankylosing spondylitis (AS) was characterised by endothelial dysfunction and the development of atherosclerotic complications. In this study, we evaluated platelet and endothelial activation parameters in AS patients. Fiftynine AS patients and 22 healthy controls were included. The clinical features and acute phase parameters were evaluated. In all patients and healthy controls, platelet-monocyte complexes (PMC), platelet-neutrophil complexes, basal and ADP-stimulated P-selectin (CD62P) expression were determined by flow cytometry; soluble E-selectin (sE-selectin) and soluble CD40L (sCD40L) were determined by ELISA. AS patients were divided into two groups as active and inactive by using BASDAI. In 15 AS patients, the evaluated parameters were assessed before and after 12 weeks of anti-TNF therapy. PMC and sCD40L levels in AS patients were significantly higher than in the control group (P values 0.013 and 0.016). The evaluated variables were similar in active and inactive AS groups (P > 0.05). There were no significant changes in platelet and endothelial activation parameters in AS patients after anti-TNF therapy (P > 0.05). Platelet activation which is reflected by high levels of PMC and sCD40L might be responsible for the increased frequency of atherosclerosis in AS. The platelet activation in our AS patients was not associated with disease activity and did not improve after anti-TNF therapy.

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Acknowledgment

This study was supported by the Scientific research projects’ fund of Trakya University (Project Number: TÜBAP-870).

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Authors and Affiliations

  1. The Department of Internal Medicine, Trakya University Medical Faculty, Edirne, Turkey

    Hüseyin Örüm

  2. Division of Hematology, Trakya University Medical Faculty, Edirne, Turkey

    Gülsüm Emel Pamuk, Muzaffer Demir & Burhan Turgut

  3. Division of Rheumatology, Trakya University Medical Faculty, Edirne, Turkey

    Ömer Nuri Pamuk & Muzaffer Demir

  4. Eski Yildiz Cad. Park Apt. No: 24 Daire: 18, Beşiktaş-İstanbul, Turkey

    Gülsüm Emel Pamuk

Authors
  1. Hüseyin Örüm
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  2. Gülsüm Emel Pamuk
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  3. Ömer Nuri Pamuk
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  4. Muzaffer Demir
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  5. Burhan Turgut
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Correspondence to Gülsüm Emel Pamuk.

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Örüm, H., Pamuk, G.E., Pamuk, Ö.N. et al. Does anti-tnf therapy cause any change in platelet activation in ankylosing spondylitis patients?. J Thromb Thrombolysis 33, 154–159 (2012). https://doi.org/10.1007/s11239-011-0663-9

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  • DOI: https://doi.org/10.1007/s11239-011-0663-9

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