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Silica sulfuric acid-catalyzed Claisen-Schmidt condensation of 1,3,4 trisubstituted pyrrole 2,5 dione to chalcones

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Abstract

A series of 11 chalcones was synthesized from 1-(4-acetylphenyl)-3,4-dibromo-1H-pyrrole-2,5-dione with various substituted benzaldehyde under solvent-free conditions using silica-sulphuric acid as a catalyst. The yields of chalcones are more than 90 %. All the compounds were characterized by physical, spectroscopic, and elemental analysis.

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Acknowledgments

The author wishes thank to the Department of Applied Chemistry, SVNIT, Surat, for providing laboratory facilities. Analytical facilities provided by the Centre of Excellence, Vapi and Central Salt & Marine Chemicals Research Institute, Bhavnagar, Gujarat, India, are gratefully acknowledged.

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Authors and Affiliations

  1. Department of Applied Chemistry, S.V. National Institute of Technology, Ichhanath, Surat, 395007, Gujarat, India

    J. R. Patel, M. H. Malani & B. Z. Dholakiya

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  1. J. R. Patel
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  2. M. H. Malani
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  3. B. Z. Dholakiya
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Correspondence to B. Z. Dholakiya.

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Patel, J.R., Malani, M.H. & Dholakiya, B.Z. Silica sulfuric acid-catalyzed Claisen-Schmidt condensation of 1,3,4 trisubstituted pyrrole 2,5 dione to chalcones. Res Chem Intermed 38, 2371–2381 (2012). https://doi.org/10.1007/s11164-012-0553-6

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  • DOI: https://doi.org/10.1007/s11164-012-0553-6

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