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On GxxxG in N-terminal stretches of type-1 VDAC/porin: critical in vertebrate apoptosis, missing in plants

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References

  • Akanda N, Tofighi R, Brask J, Tamm C, Elinder F, Ceccatelli S (2008) Voltage-dependent anion channels (VDAC) in the plasma membrane play a critical role in apoptosis in differentiated hippocampal neurons but not in neural stem cells. Cell Cycle 7:3225–3234

    Article  PubMed  CAS  Google Scholar 

  • Colombini M (2009) The published 3D structure of the VDAC channel: native or not? Trends Biochem Sci 34:382–389

    Article  PubMed  CAS  Google Scholar 

  • Curran AR, Engelman DM (2003) Sequence motifs, polar interactions and conformational changes in helical membrane proteins. Curr Opin Struct Biol 13(4):412–417

    Article  PubMed  CAS  Google Scholar 

  • De Pinto V, Prezioso G, Thinnes F, Link TA, Palmieri F (1991) Peptide-specific antibodies and proteases as probes of the transmembrane topology of the bovine heart mitochondrial porin. Biochemistry 30:10191–10200

    Article  PubMed  Google Scholar 

  • Elinder F, Akanda N, Tofighi R, Shimizu S, Tsujimoto Y, Orrenius S, Ceccatelli S (2005) Opening of plasma membrane voltage-dependent anion channels (VDAC) precedes caspase activation in neuronal apoptosis induced by toxic stimuli. Cell Death Differ 12(8):1134–1140

    Article  PubMed  CAS  Google Scholar 

  • Flörke H, Thinnes FP, Winkelbach H, Stadtmüller U, Paetzold G, Morys-Wortmann C, Hesse D, Sternbach H, Zimmermann B, Kaufmann-Kolle P et al (1994) Channel active mammalian porin, purified from crude membrane fractions of human B lymphocytes and bovine skeletal muscle, reversibly binds adenosine triphosphate (ATP). Biol Chem Hoppe Seyler 375:513–520

    Article  PubMed  Google Scholar 

  • Guo XW, Smith PR, Cognon B, D’Arcangelis D, Dolginova E, Mannella CA (1995) Molecular design of the voltage-dependent, anion-selective channel in the mitochondrial outer membrane. J Struct Biol 114:41–59

    Article  PubMed  CAS  Google Scholar 

  • Hiller S, Garces RG, Malia TJ, Orekhov VY, Colombini M, Wagner G (2008) Solution structure of the integral human membrane protein VDAC-1 in detergent micelles. Science 321:1206–1210

    Article  PubMed  CAS  Google Scholar 

  • Homblé F, Krammer EM, Prévost M (2011) Plant VDAC: facts and speculations. Biochim Biophys Acta [Epub ahead of print]

  • Hur JY, Teranishi Y, Kihara T, Yamamoto NG, Inoue M, Hosia W, Hashimoto M, Winblad B, Frykman S, Tjernberg LO (2012) Identification of novel γ-secretase associated proteins in detergent resistant membranes from brain. J Biol Chem [Epub ahead of print]

  • Marin R, Marrero-Alonso J, Fernandez C, Cury D, Diaz M (2012) Estrogen receptors in lipid raft signalling complexes for neuroprotection. Front Biosci (Elite Ed). 4:1420–1433

    Google Scholar 

  • Munter LM, Botev A, Richter L, Hildebrand PW, Althoff V, Weise C, Kaden D, Multhaup G (2010) Aberrant amyloid precursor protein (APP) processing in hereditary forms of Alzheimer disease caused by APP familial Alzheimer disease mutations can be rescued by mutations in the APP GxxxG motif. J Biol Chem 285:21636–21643

    Article  PubMed  CAS  Google Scholar 

  • Okada SF, O’Neal WK, Huang P, Nicholas RA, Ostrowski LE, Craigen WJ, Lazarowski ER, Boucher RC (2004) Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells. J Gen Physiol 124:513–526

    Article  PubMed  CAS  Google Scholar 

  • Parsons SP, Kunze WA, Huizinga JD (2011) Maxi-Channels Recorded In Situ from ICC and Pericytes Associated with the Mouse Myenteric Plexus. Am J Physiol Cell Physiol [Epub ahead of print]

  • Reymann S, Kiafard Z, Rohm B, Strutz N, Hesse D, Kratzin HD, Zimmermann B, Thinnes FP, Hilschmann N (1999) Purification procedure and monoclonal antibodies: two instruments for research on vertebrate porins. Anal Biochem 274:289–295

    Article  PubMed  CAS  Google Scholar 

  • Robert N, d’Erfurth I, Marmagne A, Erhardt M, Allot M, Boivin K, Gissot L, Monachello D, Michaud M, Duchêne AM, Barbier-Brygoo H, Maréchal-Drouard L, Ephritikhine G, Filleur S (2012) Voltage-dependent-anion-channels (VDAC) in Arabidopsis have a dual localization in the cell but show a distinct role in mitochondria. Plant Mol Biol 78:431–446

    Google Scholar 

  • Sabirov RZ, Merzlyak PG (2011) Plasmalemmal VDAC controversies and maxi-anion channel puzzle. Biochim Biophys Acta [Epub ahead of print]

  • Tateda C, Kusano T, Takahashi Y (2012) The Arabidopsis voltage-dependent anion channel 2 is required for plant growth. Plant Signal Behav 7(1):31–33

    Article  PubMed  Google Scholar 

  • Teijido O, Ujwal R, Hillerdal CO, Kullman L, Rostovtseva TK, Abramson J (2012) Affixing the N-terminal alpha helix of the voltage dependent anion channel to the channel’s wall does not prevent its voltage gating. J Biol Chem. doi: 10.1074/jbc.M111.314229

  • Thinnes FP (2009a) Trouble in VDAC field by putative inconsistencies of early antibody labelling studies. Channels 3:379–380

    Google Scholar 

  • Thinnes FP (2009b) Human type-1 VDAC, a cisplatin target involved in either apoptotic pathway. Mol Genet Metab 97:163

    Article  PubMed  CAS  Google Scholar 

  • Thinnes FP (2009c) Neuroendocrine differentiation of LNCaP cells suggests: VDAC in the cell membrane is involved in the extrinsic apoptotic pathway. Mol Genet Metab 97:241–243

    Article  PubMed  CAS  Google Scholar 

  • Thinnes FP (2010) Amyloid Aß, cut from APP by ß-secretase BACE1 and γ-secretase, induces apoptosis via opening type-1 porin/VDAC in cell membranes of hypometabolic cells-A basic model for the induction of apoptosis!? Mol Genet Metab 101:301–303

    Article  PubMed  CAS  Google Scholar 

  • Thinnes FP (2011) Apoptogenic interactions of plasmalemmal type-1 VDAC and Aβ peptides via GxxxG motifs induce Alzheimer’s disease—a basic model of apoptosis? Wien Med Wochenschr 161:274–276

    Article  PubMed  Google Scholar 

  • Thinnes FP, Reymann S (1997) New findings concerning vertebrate porin. Naturwissenschaften 84:480–498

    Article  PubMed  CAS  Google Scholar 

  • Thinnes FP, Schmid A, Benz R, Hilschmann N (1990) Studies on human porin. III. Does the voltage-dependent anion channel “Porin 31HL” form part of the chloride channel complex, which is observed in different cells and thought to be affected in cystic fibrosis? Biol Chem Hoppe Seyler 371(11):1047–1050

    Article  PubMed  CAS  Google Scholar 

  • Thinnes FP, Hellmann KP, Hellmann T, Merker R, Brockhaus-Pruchniewicz U, Schwarzer C, Walter G, Götz H, Hilschmann N (2000) Studies on human porin XXII: cell membrane integrated human porin channels are involved in regulatory volume decrease (RVD) of HeLa cells. Mol Genet Metab 69(4):331–337

    Article  PubMed  CAS  Google Scholar 

  • Yehezkel G, Abu-Hamad S, Shoshan-Barmatz V (2007) An N-terminal nucleotide-binding site in VDAC1: involvement in regulating mitochondrial function. J Cell Physiol 212:551–561

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Baumschulenweg 5, 37083, Göttingen, Germany

    Friedrich P. Thinnes

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  1. Friedrich P. Thinnes
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Correspondence to Friedrich P. Thinnes.

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This paper is a synopsis of two recent papers dealing with the multi-compartment expression pattern and function of plant voltage-dependent anion channels (VDACs) (Robert et al. 2012) and the three-dimensional structure of the mammalian type-1 VDAC (Teijido et al. 2012), respectively. These papers have raised a number of questions for discussion.

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Thinnes, F.P. On GxxxG in N-terminal stretches of type-1 VDAC/porin: critical in vertebrate apoptosis, missing in plants. Plant Mol Biol 79, 1–3 (2012). https://doi.org/10.1007/s11103-012-9900-7

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  • DOI: https://doi.org/10.1007/s11103-012-9900-7

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