Abstract
Purpose
Predicting the therapeutic effects of first-generation somatostatin receptor ligands (fg-SRLs) is important when assessing or planning effective treatment strategies in patients with acromegaly. The oft-used maximum growth hormone (GH) suppression rate parameter of the octreotide test has a suboptimal predictive value. Therefore, this study explored newer parameters of the octreotide test for predicting the therapeutic effect of long-acting fg-SRLs.
Methods
In this single-center retrospective study, the octreotide test parameters and the therapeutic effects of fg-SRL at 3 months were investigated in 45 consecutive treatment-naïve patients with acromegaly between April 2008 and March 2023. Additionally, the relationship between the octreotide test parameters and the therapeutic effects of fg-SRLs was investigated. Tumor shrinkage was evaluated based on changes in the longitudinal diameter of the macroadenomas. The area GH suppression rate-time under the curve (AUC) and the time to nadir GH level were calculated and compared with the maximum GH suppression rate.
Results
The AUC estimated reductions in serum insulin-like growth factor I, and tumor shrinkage. The time to nadir GH level predicted tumor shrinkage more robustly than the maximum GH suppression rate in patients with macroadenoma.
Conclusion
The AUC and time to nadir GH level may potentially be newer parameters of the octreotide test for estimating the therapeutic effect of fg-SRLs.
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Data and/or code availability
All relevant data are presented in the manuscript.
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The authors are grateful to Ms. K. Imura, Ms. M. Kitamura, and Ms. M. Sakoda for their assistance. The authors did not receive support from any organization for the submitted work. We would like to thank Editage (http://www.editage.jp) for English language editing.
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SU, MY, and YT: Conceptualization; SU: Data curation and investigation; SU, MY, NY, MS, HS, KK, YF, HB, HF, MT, GI, YT, and WO: Resources and formal analysis; SU: Writing—original draft preparation and Visualization; MY and YT: Writing—review and editing; MY: Project administration and Supervision. All the authors contributed to the discussion and approved the final version of the manuscript.
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Urai, S., Yamamoto, M., Yamamoto, N. et al. Newer parameters of the octreotide test in patients with acromegaly. Pituitary 27, 33–43 (2024). https://doi.org/10.1007/s11102-023-01362-z
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DOI: https://doi.org/10.1007/s11102-023-01362-z