Abstract
Purpose
This case series evaluates the surgical management of granular cell tumor (GCT) of the sellar region. This rare entity presents a unique diagnostic and surgical challenge.
Methods
Institutional neuropathology databases at Brigham and Women’s Hospital and Massachusetts General Hospital were searched for cases with a tissue diagnosis of GCT, and with a location in the sellar region. Patient, treatment, tumor, and follow-up data were extracted.
Results
Three patients had a diagnosis of GCT of the sellar region occurring over an 18-year period. All three patients were followed postoperatively at our multidisciplinary pituitary center (median follow-up = 30 months; range 12–30 months). Hormonal disturbances, an incidental lesion requiring diagnosis, and neurological symptoms were indications for surgery in these patients. Two patients underwent a craniotomy and one underwent endoscopic transsphenoidal surgery. All three patients were free of tumor recurrence at last follow-up. In one case tested, positive thyroid transcription factor-1 (TTF-1) immunohistochemistry was observed.
Conclusion
GCT is generally a benign tumor of the sellar region. Surgical resection is the standard treatment, more recently with transsphenoidal surgery when indicated. Surgical resection results in optimal outcome for patients.
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IRB approval was obtained from Brigham & Women’s Hospital (Partners) for the search and use of institutional database data. (IRB Approval #: 2015P002352).
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Ahmed, AK., Dawood, H.Y., Cote, D.J. et al. Surgical resection of granular cell tumor of the sellar region: three indications. Pituitary 22, 633–639 (2019). https://doi.org/10.1007/s11102-019-00999-z
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DOI: https://doi.org/10.1007/s11102-019-00999-z