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Immunoprofiling of glial tumours of the neurohypophysis suggests a common pituicytic origin of neoplastic cells

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Abstract

Purpose

To analyse the antigen expression profiles of 27 cases of pituicytoma, spindle cell oncocytoma, and granular cell tumour of the sellar region concerning a common pituicytic origin of neoplastic cells.

Methods

Material from 12 female and 15 male patients (13 granular cell tumours of the sellar region, 10 pituicytomas, four spindle cell oncocytomas) collected in the German Registry of Pituitary Tumours between 1993 and 2015 was re-evaluated according to the current WHO classification of tumours of the central nervous system and supplementary immunohistochemistry including S100-protein, CD56, CD68, thyroid transcription factor-1 (TTF-1), and Ki-67 was performed.

Results

S100-protein was detected in all 27 tumours and TTF-1 in all 16 tumours that were assessed. Vimentin was expressed in all 13 cases investigated whereas broad spectrum cytokeratin was not detected in any of 14 evaluated cases. GFAP was observed in nine out of 21 cases. 15 out of 17 investigated lesions showed some CD68 expression and five out of 14 cases were labelled with CD56 antibodies. Proliferative activity did not differ significantly between the three tumour subgroups although one primary and one recurrent pituicytoma showed exceptionally high Ki-67-proliferation indices of 15.3 and 12.7 %, respectively (means: granular cell tumour of the sellar region 2.0 %, pituicytoma 2.8 %, spindle cell oncocytoma 2.7 %).

Conclusions

The study confirms and expands earlier data and is in line with the notion that the three tumour types are variants of pituicytoma.

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Acknowledgments

The tumours included in the present study were drawn from the German Registry of Pituitary Tumours which is sponsored by Novartis Pharma GmbH (Nürnberg), Novo Nordisk Pharma GmbH (Mainz), Pfizer Pharma GmbH (Berlin) and Ipsen Pharma GmbH (Berlin).

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Authors and Affiliations

  1. Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    Christian Hagel, Markus Glatzel & Wolfgang Saeger

  2. Department of Neuropathology, Friedrich-Alexander University Erlangen-Nürnberg, Schwabachanlage 6, 91054, Erlangen, Germany

    Rolf Buslei

  3. Neurochirurgische Klinik, Universitätsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany

    Michael Buchfelder

  4. International Neuroscience Institute (INI), Rudolf-Pichelmayr-Str. 4, 30625, Hannover, Germany

    Rudolf Fahlbusch

  5. Klinikum Bremen-Mitte, Zentrum für Pathologie, Institut für klinische Neuropathologie, St.-Jürgen-Str. 1, 28177, Bremen, Germany

    Markus Bergmann

  6. Zentrum für Neuropathologie und Prionforschung, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 23, 81377, Munich, Germany

    Armin Giese

  7. Department of Neurosurgery, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany

    Jörg Flitsch & Dieter K. Lüdecke

Authors
  1. Christian Hagel
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  2. Rolf Buslei
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  3. Michael Buchfelder
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  4. Rudolf Fahlbusch
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  5. Markus Bergmann
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  6. Armin Giese
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  7. Jörg Flitsch
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  8. Dieter K. Lüdecke
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  9. Markus Glatzel
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  10. Wolfgang Saeger
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Corresponding author

Correspondence to Wolfgang Saeger.

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Conflict of interest

All authors (C. Hagel, R. Buslei, M. Buchfelder, R. Fahlbusch, M. Bergmann, A. Giese, J. Flitsch, D.K. Lüdecke, M. Glatzel, W. Saeger) declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards (a separate ethic review and permission of a local committee was not necessary according to §12 of the Hamburgisches Krankenhausgesetz, Hamburg, Germany).

Additional information

On behalf of the pituitary work group of the Deutsche Gesellschaft für Endokrinologie.

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Hagel, C., Buslei, R., Buchfelder, M. et al. Immunoprofiling of glial tumours of the neurohypophysis suggests a common pituicytic origin of neoplastic cells. Pituitary 20, 211–217 (2017). https://doi.org/10.1007/s11102-016-0762-x

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  • DOI: https://doi.org/10.1007/s11102-016-0762-x

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