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Comparative genome analysis of Bacillus spp. and its relationship with bioactive nonribosomal peptide production

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Abstract

Bacillus genus comprises an important number of species which produce a wide range of secondary metabolites displaying a broad spectrum of activity and great structural diversity. The genome sequences of an important number of species have been published and a large number of orphan genes reported. This review, covering all the literature in this field up to end of 2011, summarizes and compares the genetic potential of these organisms from the point of view of bioactive nonribosomal peptide production and their application as antibiotics, plant pathogen biocontrol, promotion of plant growth, etc. The biological and structural studies of the peptides isolated from Bacillus species are revised and some aspects of the biosynthesis of these metabolites and related compounds are discussed.

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Acknowledgments

I.G.C. gratefully acknowledges to Prof. Dr. A. Galvez for the carefully reading of the manuscript and MEC for Grant AGL2012-39798-CO2-01.

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  1. Department of Biology, Faculty of Sciences, University of Abdelmalek Essaadi, 2121, Tétouan, Morocco

    A. Hamdache & A. Lamarti

  2. Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Apdo. 40, 11510, Puerto Real, Cádiz, Spain

    R. Azarken, J. Aleu & I. G. Collado

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  1. A. Hamdache
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Correspondence to J. Aleu or I. G. Collado.

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Hamdache, A., Azarken, R., Lamarti, A. et al. Comparative genome analysis of Bacillus spp. and its relationship with bioactive nonribosomal peptide production. Phytochem Rev 12, 685–716 (2013). https://doi.org/10.1007/s11101-013-9278-4

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