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Practical considerations when treating chronic hepatitis E in solid organ transplant recipients

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Abstract

Hepatitis E virus (HEV) can lead to chronic infections in immunosuppressed patients. The use of ribavirin to treat chronic HEV has been well-established in case reports and guidelines. However, practical approaches to the use of this antiviral treatment in a post-transplant patient, including drug interactions, dosing adjustments, and monitoring parameters, are lacking. Thus, we present our real-world approach to the use of ribavirin to treat chronic HEV in a solid organ transplant recipient.

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Abbreviations

HEV:

Hepatitis E virus

EASL:

European association for the study of the liver

TOR:

Mammalian target of rapamycinm

PCR:

Polymerase chain reaction

CrCL:

Creatinine clearance

References

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  2. Hepatitis E. Centers for Disease Control and Prevention. 2020. https://www.cdc.gov/hepatitis/hev/index.htm. Accessed 1 Oct 2020.

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Authors and Affiliations

  1. University of Illinois at Chicago College of Pharmacy, 833 S Wood Street, Suite 164, M/C 886, Chicago, IL, 60612, USA

    David K. Choi & Michelle T. Martin

  2. Department of Medicine, Division of Gastroenterology and Hepatology, University of Illinois at Chicago, Chicago, IL, USA

    Wadih Chacra, Christine Chan, Sean Koppe, Lisa Landers, Ammara Naveed & Adam E. Mikolajczyk

Authors
  1. David K. Choi
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  2. Michelle T. Martin
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  3. Wadih Chacra
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  4. Christine Chan
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  5. Sean Koppe
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  6. Lisa Landers
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  7. Ammara Naveed
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  8. Adam E. Mikolajczyk
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Corresponding author

Correspondence to David K. Choi.

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Choi, D.K., Martin, M.T., Chacra, W. et al. Practical considerations when treating chronic hepatitis E in solid organ transplant recipients . Int J Clin Pharm 43, 753–755 (2021). https://doi.org/10.1007/s11096-020-01195-x

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  • DOI: https://doi.org/10.1007/s11096-020-01195-x

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