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Implants as Targeted Drug Delivery Systems (Review)

  • DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY
  • Published:
Pharmaceutical Chemistry Journal Aims and scope

This review considers implants as modern drug delivery systems. Methods of their production by hot melt extrusion, direct pressing, and 3D printing are described. The advantages and disadvantages of implants produced by different methods are shown. The nomenclature and basic requirements for excipients necessary for effective use of the dosage forms are given. An assortment of polymers used to produce biodegradable and non-biodegradable implants is presented. Requirements for excipients for a particular method of producing a drug delivery system are described. The prospects and advantages of in situ implants as an alternative technology to produce drugs for targeted therapy are shown. Recent developments and drugs already approved for implants for ophthalmic, dental, and intranasal application and for targeted therapy of oncological diseases are reviewed.

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References

  1. K. Kotova, Dental Magazine (2019); https://dentalmagazine.ru/lichnyi_opyt/istorija-odnoj-veshhi-dentalnye-implantaty.htm.

  2. K. Warwick, M. Gasson, B. Hutt, et al., Arch. Neurol., 60(10), 1369 – 1373 (2003).

    Article  Google Scholar 

  3. K. Battiston, I. Parrag, M. Statham, et al., Nat. Commun., 12(1), 2875 (2021).

    Article  CAS  Google Scholar 

  4. M. Pozdneeva, Katren Style [in Russian], 203 (2020); https://www.katrenstyle.ru/goods_sales/peredovaya farmakologiya implantaty.

  5. A. Julio, A. Sultane, A. S. Viana, et al., Pharmaceutics, 13(8), 1163 (2021).

    Article  CAS  Google Scholar 

  6. A. Kumar and J. Pillai, “Implantable drug delivery systems: An overview,” in: Nanostructures for the Engineering of Cells, Tissues Organs, A. M. Grumezescu (ed.), Elsevier (2018), Chap. 13, pp. 473 – 511.

  7. F. Kreye, F. Siepmann, J. F. Willart, et al., Eur. J. Pharm. Biopharm., 78, 394 – 400 (2011).

    Article  CAS  Google Scholar 

  8. E. V. Blynskaya, S. V. Tishkov, and K. V. Alekseev, Razrab. Regist. Lek Sredstv, No. 3, 10 – 19 (2018).

  9. I. D. Ursan, L. Chiu, and A. Pierce, J. Am. Pharm. Assoc., 53(2), 136 – 144 (2013).

    Article  Google Scholar 

  10. W. Zhu, X. Ma, M. Gou, et al., Curr. Opin. Biotechnol., 40, 103 – 112 (2016).

    Article  CAS  Google Scholar 

  11. S. Kotta, A. Nair, and N. Alsabeelah, Curr. Pharm. Des., 24(42), 5039 – 5048 (2018).

    Article  CAS  Google Scholar 

  12. B. C. Gross, J. L. Erkal, S. Y. Lockwood, et al., Anal. Chem., 86(7), 3240 – 3253 (2014).

    Article  CAS  Google Scholar 

  13. A. Fayzullin, S. Churbanov, N. Ignatieva, et al., Biomedicines, 9(8), 853 (2021).

    Article  CAS  Google Scholar 

  14. E. O. Bakhrushina, N. B. Demina, M. M. Shumkova, et al., Razrab. Regist. Lek. Sredstv, 10(4), 54 – 63 (2021).

    CAS  Google Scholar 

  15. J. C. Quarterman, S. M. Geary, and A. K. Salem, Eur. J. Pharm. Biopharm., 159, 21 – 35 (2021).

    Article  CAS  Google Scholar 

  16. A. A. Raheem, P. Hameed, R. Whenish, et al., Biomimetics (Basel), 6(4), 65 (2021).

    Article  Google Scholar 

  17. B. Gupta, V. Mishra, S. Gharat, et al., Pharmaceuticals (Basel), 14(11), 1201 (2021).

    Article  CAS  Google Scholar 

  18. T. Ferry, C. Batailler, C. Petitjean, et al., Front. Med. (Lausanne), 7, 342 (2020).

    Article  Google Scholar 

  19. W. Xi, V. Hegde, S. D. Zoller, et al., Nat. Commun., 12, No. 1, 5473 (2021).

    Article  CAS  Google Scholar 

  20. https://iluvien.com/patient-journey/

  21. M. Hikal, N. Celik, G. U. Auffarth, et al., J. Clin. Med., 10, 3966 (2021).

    Article  CAS  Google Scholar 

  22. R. Thakur and D. Jones, On Drug Delivery, 82, 28 – 31 (2018).

    Google Scholar 

  23. E. O. Bakhrushina, M. N. Anurova, N. B. Demina, et al., Razrab. Regist. Lek. Sredstv, 10(1), 57 – 66 (2021).

    CAS  Google Scholar 

  24. D. D. Kalyapin; https://cyberleninka.ru/article/n/ (accessed Dec. 28, 2021).

  25. R. Taulu, J. Numminen, A. Bizaki, et al., Eur. Arch. Otorhinolaryngol., 272, 2335 – 2340 (2015).

    Article  Google Scholar 

  26. T. Hickey, D. Kreutzer, D. J. Burgess, et al., Biomaterials, 23(7), 1649 – 1656 (2002).

    Article  CAS  Google Scholar 

  27. D. W. Kennedy, Expert Rev. Respirat. Med., 6(5), 493 – 498 (2012).

    Article  CAS  Google Scholar 

  28. A. Parikh, U. Anand, M. C. Ugwu, et al., Pharmaceutics, 6(2), 249 – 267 (2014).

    Article  Google Scholar 

  29. A. B. W. Alecio, C. F. Ferreira, J. Babu, et al., J. Oral Implantol., 45(4), 267 – 273 (2019).

    Article  Google Scholar 

  30. P. Wychowanski, A. Starzynska, P. Adamska, et al., Antibiotics (Basel), 10(8), 919 (2021).

    Article  CAS  Google Scholar 

  31. Atridox (Doxycycline Hyclate); https://www.rxlist.com/atridox-drug.htm (accessed Nov. 5, 2021).

  32. S. A. Yehia, A. Halim, and M. Y. Aziz, Curr. Drug. Delivery, 8(15), 1193 – 1203 (2018).

    Article  Google Scholar 

  33. J. Ge, T. Liu, T. Lei, et al., Front. Pharmacol., 12, 659258 (2021).

  34. H. Li, Z. Liu, L. Yuan, et al., Cancers (Basel), 13(21), 5459 (2021).

    Article  CAS  Google Scholar 

  35. V. Domsta and A. Seidlitz, Molecules, 26(13), 4066 (2021).

    Article  CAS  Google Scholar 

  36. L. Gao, S. Cai, A. Cai, et al., Drug Delivery, 26(1), 208 – 215 (2019).

    Article  Google Scholar 

  37. L. Gao, Q. Li, J. Zhang, et al., Drug Delivery, 26(1), 1049 – 1057 (2019).

    Article  CAS  Google Scholar 

  38. N. Yang, H. Chen, H. Han, et al., Int. J. Pharm., 552(1 – 2), 91 – 98 (2018).

  39. Z. Jing, R. Ni, J. Wang, et al., Bioact. Mater., 6(12), 4542 – 4557 (2021).

    Article  CAS  Google Scholar 

  40. C. Dharmayanti, T. A. Gillam, D. B. Williams, et al., Polymers (Basel), 12(12), 2930 (2020).

    Article  CAS  Google Scholar 

  41. C. Wu, X. Yi, R. Xu, et al., Drug Delivery, 27(1), 974 – 982 (2020).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. A. P. Nelyubin Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, 96/1 Prosp. Vernadskogo, Moscow, 119571, Russia

    E. O. Bakhrushina & N. B. Demina

Authors
  1. E. O. Bakhrushina
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  2. N. B. Demina
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Corresponding author

Correspondence to N. B. Demina.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 56, No. 3, pp. 42 – 49, March, 2022.

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Bakhrushina, E.O., Demina, N.B. Implants as Targeted Drug Delivery Systems (Review). Pharm Chem J 56, 396–402 (2022). https://doi.org/10.1007/s11094-022-02649-4

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  • DOI: https://doi.org/10.1007/s11094-022-02649-4

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